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Oxidized-morpholine dressing ratiometric fluorescent probe for specifically visualizing the intracellular glutathione

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成果类型:
期刊论文、会议论文
作者:
Liu, Guotao;Han, Xie;Zhang, Jing;Xu, Zhiqiang;Liu, Sheng Hua;...
通讯作者:
Yin, Jun;Zeng, Lintao
作者机构:
[Zhang, Jing; Liu, Sheng Hua; Xu, Zhiqiang; Yin, Jun; Han, Xie; Liu, Guotao] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
[Zeng, Lintao] Tianjin Univ Technol, Sch Chem & Chem Engn, Tianjin 300384, Peoples R China.
通讯机构:
[Yin, Jun] C
[Zeng, Lintao] T
Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
Tianjin Univ Technol, Sch Chem & Chem Engn, Tianjin 300384, Peoples R China.
语种:
英文
关键词:
Ratiometric fluorescent probes;Glutathione detection;Oxidation-induced;Naphthalimide sulfonamide
期刊:
Dyes and Pigments
ISSN:
0143-7208
年:
2018
卷:
148
页码:
292-297
会议名称:
第十届全国化学生物学学术会议
会议论文集名称:
第十届全国化学生物学学术会议论文摘要集(墙报)
会议时间:
2017-09-23
会议地点:
中国湖北武汉
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21676113, 21402057, 21472059]; Youth Chen-Guang Project of Wuhan [2016070204010098]; 111 ProjectMinistry of Education, China - 111 Project [B17019]; Ministry -Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Shenzhen; self-determined research funds of CCNU from the colleges' basic research and operation of MOE [CCNU16A02004]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A naphthalimide-based ratiometric fluorescent probe for determining glutathione (GSH) was constructed by installing two oxidized morpholine (e.g. thiomorpholine-S-dioxide and morpholine-N-oxide) components on the “off-to-on” GSH probe. This probe displayed high selectivity towards GSH. As well, the bioimaging application confirmed that this probe was capable of acting as an indicator to monitor the intracellular GSH. Thus, this work provides a promising strategy to constru...

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