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Dual Roles of Methyl Ketones in Radziszewski-Type Reaction: Formal [2 + 1 + 1 + 1] Synthesis of 1,2,5-Trisubstituted Imidazoles

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成果类型:
期刊论文
作者:
Zhang, Jingjing;Gao, Qinghe;Wu, Xia;Geng, Xiao;Wu, Yan-Dong*;...
通讯作者:
Wu, Yan-Dong;Wu, Anxin(吴安心
作者机构:
[Wu, Anxin; Zhang, Jingjing; Geng, Xiao; Wu, Yan-Dong; Gao, Qinghe; Wu, Xia] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构:
[Wu, YD; Wu, AX] C
Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
语种:
英文
期刊:
Organic Letters
ISSN:
1523-7060
年:
2016
卷:
18
期:
7
页码:
1686-1689
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21272085, 21472056]; excellent doctorial dissertation cultivation grant from Central China Normal University [2015YBYB019]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A highly efficient molecular iodine mediated Radziszewski-type reaction of methyl ketones, anilines, and tosylmethyl isocyanide has been developed. This protocol represents an elegant molecular fragment assembly of imidazoles via a formal [2 + 1 + 1 + 1] annulation. It is the first example where methyl ketones serve as the α-dicarbonyl compounds and a...

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