An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy

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成果类型：

期刊论文

作者：

Wang, Ying-Qing;Wang, Ping-Yuan;Wang, Yu-Ting;Yang, Guang-Fu（杨光富）;Zhang, Ao*;...

通讯作者：

Miao, Ze-Hong;Zhang, Ao

作者机构：

[Miao, Ze-Hong; Wang, Ying-Qing; Wang, Yu-Ting] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China.

[Zhang, Ao; Wang, Ping-Yuan] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Lu,Bldg 3,Room 426, Shanghai 201203, Peoples R China.

[Zhang, Ao; Wang, Ping-Yuan] Chinese Acad Sci, Shanghai Inst Mat Med, Synthet Organ & Med Chem Lab, 555 Zuchongzhi Lu,Bldg 3,Room 426, Shanghai 201203, Peoples R China.

[Yang, Guang-Fu; Wang, Ping-Yuan] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.

通讯机构：

[Miao, Ze-Hong; Zhang, Ao] C

Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China.

Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Lu,Bldg 3,Room 426, Shanghai 201203, Peoples R China.

Chinese Acad Sci, Shanghai Inst Mat Med, Synthet Organ & Med Chem Lab, 555 Zuchongzhi Lu,Bldg 3,Room 426, Shanghai 201203, Peoples R China.

语种：

英文

期刊：

JOURNAL OF MEDICINAL CHEMISTRY

ISSN：

0022-2623

年：

2016

卷：

期：

页码：

9575-9598

DOI：

10.1021/acs.jmedchem.6b00055

基金类别：

National Basic Research Program of ChinaNational Basic Research Program of China [2012CB932502, 2015CB910603]; National Science AMP; Technology Major Project "Key New Drug Creation and Manufacturing Program" of China [2016ZX09101009]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81573450, 81321092, 81430080]; Chinese Academy of SciencesChinese Academy of Sciences [XDA12020104, CASIMM0120152003, CASIMM0120153005]; Chinese Academy of Sciences (Hundred Talents Project); Science and Technology Commission of Shanghai MunicipalityScience & Technology Commission of Shanghai Municipality (STCSM) [16JC1406300, 14431905300]; State Key Laboratory of Drug Research [SIMM1601ZZ-03]

机构署名：

本校为其他机构

院系归属：

化学学院

摘要：

Poly(ADP-ribose)polymerase-1 (PARP-1) is a critical DNA repair enzyme in the base excision repair pathway. Inhibitors of this enzyme comprise a new type of anticancer drug that selectively kills cancer cells by targeting homologous recombination repair defects. Since 2010, important advances have been achieved in PARP-1 inhibitors. Specifically, the approval of olaparib in 2014 for the treatment of ovarian cancer with BRCA mutations validated PARP-1 as an anticancer target and established its clinical importance in cancer therapy. Here, we provide an update on PARP-1 inhibitors, focusing on br...

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An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy

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