期刊论文

Yang, Guang-Fu

英文

Drug Discovery Today

1359-6446

2012

17

19-20

1121-1126

10.1016/j.drudis.2012.06.018

National Basic Research Program of ChinaNational Basic Research Program of China [2010CB126103]; NSFCNational Natural Science Foundation of China (NSFC) [20925206, 20932005]; NSFNational Science Foundation (NSF) [CHE-1111761]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [RC1MH088480]; NATIONAL INSTITUTE OF MENTAL HEALTHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [RC1MH088480, RC1MH088480] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON DRUG ABUSEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Drug Abuse (NIDA) [R01DA032910, R01DA025100, R01DA025100, R01DA025100, R01DA032910, R01DA032910, R01DA025100, R01DA032910, R01DA032910, R01DA025100] Funding Source: NIH RePORTER

本校为第一且通讯机构

Drug resistance has become one of the biggest challenges in drug discovery and/or development and has attracted great research interests worldwide. During the past decade, computational strategies have been developed to predict target mutation-induced drug resistance. Meanwhile, various molecular design strategies, including targeting protein backbone, targeting highly conserved residues and dual/multiple targeting, have been used to design novel inhibitors for combating the drug resistance. In this article we review recent advances in developm...