版权说明 帮助中心
首页 > 成果 > 详情

Guidelines for the use and interpretation of assays for monitoring autophagy

ESI高被引SCI-E
WOS被引频次:2039
认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Klionsky, Daniel J.;Abdalla, Fabio C.;Abeliovich, Hagai;Abraham, Robert T.;Acevedo-Arozena, Abraham;Adeli, Khosrow;Agholme, Lotta;Agnello, Maria;Agostinis, Patrizia;Aguirre-Ghiso, Julio A.;Ahn, Hyung Jun;Ait-Mohamed, Ouardia;Ait-Si-Ali, Slimane;Akematsu, Takahiko;Akira, Shizuo;Al-Younes, Hesham M.;Al-Zeer, Munir A.;Albert, Matthew L.;Albin, Roger L.;Alegre-Abarrategui, Javier;Aleo, Maria Francesca;Alirezaei, Mehrdad;Almasan, Alexandru;Almonte-Becerril, Maylin;Amano, Atsuo;Amaravadi, Ravi;Amarnath, Shoba;Amer, Amal O.;Andrieu-Abadie, Nathalie;Anantharam, Vellareddy;Ann, David K.;Anoopkumar-Dukie, Shailendra;Aoki, Hiroshi;Apostolova, Nadezda;Arancia, Giuseppe;Aris, John P.;Asanuma, Katsuhiko;Asare, Nana Y. O.;Ashida, Hisashi;Askanas, Valerie;Askew, David S.;Auberger, Patrick;Baba, Misuzu;Backues, Steven K.;Baehrecke, Eric H.;Bahr, Ben A.;Bai, Xue-Yuan;Bailly, Yannick;Baiocchi, Robert;Baldini, Giulia;Balduini, Walter;Ballabio, Andrea;Bamber, Bruce A.;Bampton, Edward T. W.;Banhegyi, Gabor;Bartholomew, Clinton R.;Bassham, Diane C.;Bast, Robert C., Jr.;Batoko, Henri;Bay, Boon-Huat;Beau, Isabelle;Bechet, Daniel M.;Begley, Thomas J.;Behl, Christian;Behrends, Christian;Bekri, Soumeya;Bellaire, Bryan;Bendall, Linda J.;Benetti, Luca;Berliocchi, Laura;Bernardi, Henri;Bernassola, Francesca;Besteiro, Sebastien;Bhatia-Kissova, Ingrid;Bi, Xiaoning;Biard-Piechaczyk, Martine;Blum, Janice S.;Boise, Lawrence H.;Bonaldo, Paolo;Boone, David L.;Bornhauser, Beat C.;Bortoluci, Karina R.;Bossis, Ioannis;Bost, Frederic;Bourquin, Jean-Pierre;Boya, Patricia;Boyer-Guittaut, Michael;Bozhkov, Peter V.;Brady, Nathan R.;Brancolini, Claudio;Brech, Andreas;Brenman, Jay E.;Brennand, Ana;Bresnick, Emery H.;Brest, Patrick;Bridges, Dave;Bristol, Molly L.;Brookes, Paul S.;Brown, Eric J.;Brumell, John H.;Brunetti-Pierri, Nicola;Brunk, Ulf T.;Bulman, Dennis E.;Bultman, Scott J.;Bultynck, Greet;Burbulla, Lena F.;Bursch, Wilfried;Butchar, Jonathan P.;Buzgariu, Wanda;Bydlowski, Sergio P.;Cadwell, Ken;Cahova, Monika;Cai, Dongsheng;Cai, Jiyang;Cai, Qian;Calabretta, Bruno;Calvo-Garrido, Javier;Camougrand, Nadine;Campanella, Michelangelo;Campos-Salinas, Jenny;Candi, Eleonora;Cao, Lizhi;Caplan, Allan B.;Carding, Simon R.;Cardoso, Sandra M.;Carew, Jennifer S.;Carlin, Cathleen R.;Carmignac, Virgine;Carneiro, Leticia A. M.;Carra, Serena;Caruso, Rosario A.;Casari, Giorgio;Casas, Caty;Castino, Roberta;Cebollero, Eduardo;Cecconi, Francesco;Celli, Jean;Chaachouay, Hassan;Chae, Han-Jung;Chai, Chee-Yin;Chan, David C.;Chan, Edmond Y.;Chang, Raymond Chuen-Chung;Che, Chi-Ming;Chen, Ching-Chow;Chen, Guang-Chao;Chen, Guo-Qiang;Chen, Min;Chen, Quan;Chen, Steve S. -L.;Chen, WenLi;Chen, Xi;Chen, Xiangmei;Chen, Xiequn;Chen, Ye-Guang;Chen, Yingyu;Chen, Yongqiang;Chen, Yu-Jen;Chen, Zhixiang;Cheng, Alan;Cheng, Christopher H. K.;Cheng, Yan;Cheong, Heesun;Cheong, Jae-Ho;Cherry, Sara;Chess-Williams, Russ;Cheung, Zelda H.;Chevet, Eric;Chiang, Hui-Ling;Chiarelli, Roberto;Chiba, Tomoki;Chin, Lih-Shen;Chiou, Shih-Hwa;Chisari, Francis V.;Cho, Chi Hin;Cho, Dong-Hyung;Choi, Augustine M. K.;Choi, DooSeok;Choi, Kyeong Sook;Choi, Mary E.;Chouaib, Salem;Choubey, Divaker;Choubey, Vinay;Chu, Charleen T.;Chuang, Tsung-Hsien;Chueh, Sheau-Huei;Chun, Taehoon;Chwae, Yong-Joon;Chye, Mee-Len;Ciarcia, Roberto;Ciriolo, Maria R.;Clague, Michael J.;Clark, Robert S. B.;Clarke, Peter G. H.;Clarke, Robert;Codogno, Patrice;Coller, Hilary A.;Colombo, Maria I.;Comincini, Sergio;Condello, Maria;Condorelli, Fabrizio;Cookson, Mark R.;Coppens, Graham H. Coombs Isabelle;Corbalan, Ramon;Cossart, Pascale;Costelli, Paola;Costes, Safia;Coto-Montes, Ana;Couve, Eduardo;Coxon, Fraser P.;Cregg, James M.;Crespo, Jose L.;Cronje, Marianne J.;Cuervo, Ana Maria;Cullen, Joseph J.;Czaja, Mark J.;D'Amelio, Marcello;Darfeuille-Michaud, Arlette;Davids, Lester M.;Davies, Faith E.;De Felici, Massimo;de Groot, John F.;de Haan, Cornelis A. M.;De Martino, Luisa;De Milito, Angelo;De Tata, Vincenzo;Debnath, Jayanta;Degterev, Alexei;Dehay, Benjamin;Delbridge, Lea M. D.;Demarchi, Francesca;Deng, Yi Zhen;Dengjel, Joen;Dent, Paul;Denton, Donna;Deretic, Vojo;Desai, Shyamal D.;Devenish, Rodney J.;Di Gioacchino, Mario;Di Paolo, Gilbert;Di Pietro, Chiara;Diaz-Araya, Guillermo;Diaz-Laviada, Ines;Diaz-Meco, Maria T.;Diaz-Nido, Javier;Dikic, Ivan;Dinesh-Kumar, Savithramma P.;Ding, Wen-Xing;Distelhorst, Clark W.;Diwan, Abhinav;Djavaheri-Mergny, Mojgan;Dokudovskaya, Svetlana;Dong, Zheng;Dorsey, Frank C.;Dosenko, Victor;Dowling, James J.;Doxsey, Stephen;Dreux, Marlene;Drew, Mark E.;Duan, Qiuhong;Duchosal, Michel A.;Duff, Karen;Dugail, Isabelle;Durbeej, Madeleine;Duszenko, Michael;Edelstein, Charles L.;Edinger, Aimee L.;Egea, Gustavo;Eichinger, Ludwig;Eissa, N. Tony;Ekmekcioglu, Suhendan;El-Deiry, Wafik S.;Elazar, Zvulun;Elgendy, Mohamed;Ellerby, Lisa M.;Eng, Kai Er;Engelbrecht, Anna-Mart;Engelender, Simone;Erenpreisa, Jekaterina;Escalante, Ricardo;Esclatine, Audrey;Eskelinen, Eeva-Liisa;Espert, Lucile;Espina, Virginia;Fan, Huizhou;Fan, Jia;Fan, Qi-Wen;Fan, Zhen;Fang, Shengyun;Fang, Yongqi;Fanto, Manolis;Fanzani, Alessandro;Farkas, Thomas;Farre, Jean-Claude;Faure, Mathias;Fechheimer, Marcus;Feng, Carl G.;Feng, Jian;Feng, Qili;Feng, Youji;Fesues, Laszlo;Feuer, Ralph;Figueiredo-Pereira, Maria E.;Fimia, Gian Maria;Fingar, Diane C.;Finkbeiner, Steven;Finkel, Toren;Finley, Kim D.;Fiorito, Filomena;Fisher, Edward A.;Fisher, Paul B.;Flajolet, Marc;Florez-McClure, Maria L.;Florio, Salvatore;Fon, Edward A.;Fornai, Francesco;Fortunato, Franco;Fotedar, Rati;Fowler, Daniel H.;Fox, Howard S.;Franco, Rodrigo;Frankel, Lisa B.;Fransen, Marc;Fuentes, Jose M.;Fueyo, Juan;Fujii, Jun;Fujisaki, Kozo;Fujita, Eriko;Fukuda, Mitsunori;Furukawa, Ruth H.;Gaestel, Matthias;Gailly, Philippe;Gajewska, Malgorzata;Galliot, Brigitte;Galy, Vincent;Ganesh, Subramaniam;Ganetzky, Barry;Ganley, Ian G.;Gao, Fen-Biao;Gao, George F.;Gao, Jinming;Garcia, Lorena;Garcia-Manero, Guillermo;Garcia-Marcos, Mikel;Garmyn, Marjan;Gartel, Andrei L.;Gatti, Evelina;Gautel, Mathias;Gawriluk, Thomas R.;Gegg, Matthew E.;Geng, Jiefei;Germain, Marc;Gestwicki, Jason E.;Gewirtz, David A.;Ghavami, Saeid;Ghosh, Pradipta;Giammarioli, Anna M.;Giatromanolaki, Alexandra N.;Gibson, Spencer B.;Gilkerson, Robert W.;Ginger, Michael L.;Ginsberg, Henry N.;Golab, Jakub;Goligorsky, Michael S.;Golstein, Pierre;Gomez-Manzano, Candelaria;Goncu, Ebru;Gongora, Celine;Gonzalez, Claudio D.;Gonzalez, Ramon;Gonzalez-Estevez, Cristina;Gonzalez-Polo, Rosa Ana;Gonzalez-Rey, Elena;Gorbunov, Nikolai V.;Gorski, Sharon;Goruppi, Sandro;Gottlieb, Roberta A.;Gozuacik, Devrim;Granato, Giovanna Elvira;Grant, Gary D.;Green, Kim N.;Gregorc, Ales;Gros, Frederic;Grose, Charles;Grunt, Thomas W.;Gual, Philippe;Guan, Jun-Lin;Guan, Kun-Liang;Guichard, Sylvie M.;Gukovskaya, Anna S.;Gukovsky, Ilya;Gunst, Jan;Gustafsson, Asa B.;Halayko, Andrew J.;Hale, Amber N.;Halonen, Sandra K.;Hamasaki, Maho;Han, Feng;Han, Ting;Hancock, Michael K.;Hansen, Malene;Harada, Hisashi;Harada, Masaru;Hardt, Stefan E.;Harper, J. Wade;Harris, Adrian L.;Harris, James;Harris, Steven D.;Hashimoto, Makoto;Haspel, Jeffrey A.;Hayashi, Shin-ichiro;Hazelhurst, Lori A.;He, Congcong;He, You-Wen;Hebert, Marie-Josee;Heidenreich, Kim A.;Helfrich, Miep H.;Helgason, Gudmundur V.;Henske, Elizabeth P.;Herman, Brian;Herman, Paul K.;Hetz, Claudio;Hilfiker, Sabine;Hill, Joseph A.;Hocking, Lynne J.;Hofman, Paul;Hofmann, Thomas G.;Hoehfeld, Joerg;Holyoake, Tessa L.;Hong, Ming-Huang;Hood, David A.;Hotamisligil, Goekhan S.;Houwerzijl, Ewout J.;Hoyer-Hansen, Maria;Hu, Bingren;Hu, Chien-An A.;Hu, Hong-Ming;Hua, Ya;Huang, Canhua;Huang, Ju;Huang, Shengbing;Huang, Wei-Pang;Huber, Tobias B.;Huh, Won-Ki;Hung, Tai-Ho;Hupp, Ted R.;Hur, Gang Min;Hurley, James B.;Hussain, Sabah N. A.;Hussey, Patrick J.;Hwang, Jung Jin;Hwang, Seungmin;Ichihara, Atsuhiro;Ilkhanizadeh, Shirin;Inoki, Ken;Into, Takeshi;Iovane, Valentine;Iovanna, Juan L.;Ip, Nancy Y.;Isaka, Yoshitaka;Ishida, Hiroyuki;Isidoro, Ciro;Isobe, Ken-ichi;Iwasaki, Akiko;Izquierdo, Marta;Izumi, Yotaro;Jaakkola, Panu M.;Jaattela, Marja;Jackson, George R.;Jackson, William T.;Janji, Bassam;Jendrach, Marina;Jeon, Ju-Hong;Jeung, Eui-Bae;Jiang, Hong;Jiang, Hongchi;Jiang, Jean X.;Jiang, Ming;Jiang, Qing;Jiang, Xuejun;Jiang, Xuejun;Jimenez, Alberto;Jin, Meiyan;Jin, Shengkan;Joe, Cheol O.;Johansen, Terje;Johnson, Daniel E.;Johnson, Gail V. W.;Jones, Nicola L.;Joseph, Bertrand;Joseph, Suresh K.;Joubert, Annie M.;Juhasz, Gabor;Juillerat-Jeanneret, Lucienne;Jung, Chang Hwa;Jung, Yong-Keun;Kaarniranta, Kai;Kaasik, Allen;Kabuta, Tomohiro;Kadowaki, Motoni;Kagedal, Katarina;Kamada, Yoshiaki;Kaminskyy, Vitaliy O.;Kampinga, Harm H.;Kanamori, Hiromitsu;Kang, Chanhee;Kang, Khong Bee;Kang, Kwang Il;Kang, Rui;Kang, Yoon-A;Kanki, Tomotake;Kanneganti, Thirumala-Devi;Kanno, Haruo;Kanthasamy, Anumantha G.;Kanthasamy, Arthi;Karantza, Vassiliki;Kaushal, Gur P.;Kaushik, Susmita;Kawazoe, Yoshinori;Ke, Po-Yuan;Kehrl, John H.;Kelekar, Ameeta;Kerkhoff, Claus;Kessel, David H.;Khalil, Hany;Kiel, Jan A. K. W.;Kiger, Amy A.;Kihara, Akio;Kim, Deok Ryong;Kim, Do-Hyung;Kim, Dong-Hou;Kim, Eun-Kyoung;Kim, Hyung-Ryong;Kim, Jae-Sung;Kim, Jeong Hun;Kim, Jin Cheon;Kim, John K.;Kim, Peter K.;Kim, Seong Who;Kim, Yong-Sun;Kim, Yonghyun;Kimchi, Adi;Kimmelman, Alec C.;King, Jason S.;Kinsella, Timothy J.;Kirkin, Vladimir;Kirshenbaum, Lorrie A.;Kitamoto, Katsuhiko;Kitazato, Kaio;Klein, Ludger;Klimecki, Walter T.;Klucken, Jochen;Knecht, Erwin;Ko, Ben C. B.;Koch, Jan C.;Koga, Hiroshi;Koh, Jae-Young;Koh, Young Ho;Koike, Masato;Komatsu, Masaaki;Kominami, Eiki;Kong, Hee Jeong;Kong, Wei-Jia;Korolchuk, Viktor I.;Kotake, Yaichiro;Koukourakis, Michael I.;Flores, Juan B. Kouri;Kovacs, Attila L.;Kraft, Claudine;Krainc, Dimitri;Kraemer, Helmut;Kretz-Remy, Carole;Krichevsky, Anna M.;Kroemer, Guido;Krueger, Rejko;Krut, Oleg;Ktistakis, Nicholas T.;Kuan, Chia-Yi;Kucharczyk, Roza;Kumar, Ashok;Kumar, Raj;Kumar, Sharad;Kundu, Mondira;Kung, Hsing-Jien;Kurz, Tino;Kwon, Ho Jeong;La Spada, Albert R.;Lafont, Frank;Lamark, Trond;Landry, Jacques;Lane, Jon D.;Lapaquette, Pierre;Laporte, Jocelyn F.;Laszlo, Lajos;Lavandero, Sergio;Lavoie, Josee N.;Layfield, Robert;Lazo, Pedro A.;Le, Weidong;Le Cam, Laurent;Ledbetter, Daniel J.;Lee, Alvin J. X.;Lee, Byung-Wan;Lee, Gyun Min;Lee, Jongdae;Lee, Ju-Hyun;Lee, Michael;Lee, Myung-Shik;Lee, Sug Hyung;Leeuwenburgh, Christiaan;Legembre, Patrick;Legouis, Renaud;Lehmann, Michael;Lei, Huan-Yao;Lei, Qun-Ying;Leib, David A.;Leiro, Jose;Lemasters, John J.;Lemoine, Antoinette;Lesniak, Maciej S.;Lev, Dina;Levenson, Victor V.;Levine, Beth;Levy, Efrat;Li, Faqiang;Li, Jun-Lin;Li, Lian;Li, Sheng;Li, Weijie;Li, Xue-Jun;Li, Yan-bo;Li, Yi-Ping;Liang, Chengyu;Liang, Qiangrong;Liao, Yung-Feng;Liberski, Pawel P.;Lieberman, Andrew;Lim, Hyunjung J.;Lim, Kah-Leong;Lim, Kyu;Lin, Chiou-Feng;Lin, Fu-Cheng;Lin, Jian;Lin, Jiandie D.;Lin, Kui;Lin, Wan-Wan;Lin, Weei-Chin;Lin, Yi-Ling;Linden, Rafael;Lingor, Paul;Lippincott-Schwartz, Jennifer;Lisanti, Michael P.;Liton, Paloma B.;Liu, Bo;Liu, Chun-Feng;Liu, Kaiyu;Liu, Leyuan;Liu, Qiong A.;Liu, Wei;Liu, Young-Chau;Liu, Yule;Lockshin, Richard A.;Lok, Chun-Nam;Lonial, Sagar;Loos, Benjamin;Lopez-Berestein, Gabriel;Lopez-Otin, Carlos;Lossi, Laura;Lotze, Michael T.;Low, Peter;Lu, Binfeng;Lu, Bingwei;Lu, Bo;Lu, Zhen;Luciano, Frederic;Lukacs, Nicholas W.;Lund, Anders H.;Lynch-Day, Melinda A.;Ma, Yong;Macian, Fernando;MacKeigan, Jeff P.;Macleod, Kay F.;Madeo, Frank;Maiuri, Luigi;Maiuri, Maria Chiara;Malagoli, Davide;Malicdan, May Christine V.;Malorni, Walter;Man, Na;Mandelkow, Eva-Maria;Manon, Stephen;Manov, Irena;Mao, Kai;Mao, Xiang;Mao, Zixu;Marambaud, Philippe;Marazziti, Daniela;Marcel, Yves L.;Marchbank, Katie;Marchetti, Piero;Marciniak, Stefan J.;Marcondes, Mateus;Mardi, Mohsen;Marfe, Gabriella;Marino, Guillermo;Markaki, Maria;Marten, Mark R.;Martin, Seamus J.;Martinand-Mari, Camille;Martinet, Wim;Martinez-Vicente, Marta;Masini, Matilde;Matarrese, Paola;Matsuo, Saburo;Matteoni, Raffaele;Mayer, Andreas;Mazure, Nathalie M.;McConkey, David J.;McConnell, Melanie J.;McDermott, Catherine;McDonald, Christine;McInerney, Gerald M.;McKenna, Sharon L.;McLaughlin, BethAnn;McLean, Pamela J.;McMaster, Christopher R.;McQuibban, G. Angus;Meijer, Alfred J.;Meisler, Miriam H.;Melendez, Alicia;Melia, Thomas J.;Melino, Gerry;Mena, Maria A.;Menendez, Javier A.;Menna-Barreto, Rubem F. S.;Menon, Manoj B.;Menzies, Fiona M.;Mercer, Carol A.;Merighi, Adalberto;Merry, Diane E.;Meschini, Stefania;Meyer, Christian G.;Meyer, Thomas F.;Miao, Chao-Yu;Miao, Jun-Ying;Michels, Paul A. M.;Michiels, Carine;Mijaljica, Dalibor;Milojkovic, Ana;Minucci, Saverio;Miracco, Clelia;Miranti, Cindy K.;Mitroulis, Ioannis;Miyazawa, Keisuke;Mizushima, Noboru;Mograbi, Baharia;Mohseni, Simin;Molero, Xavier;Mollereau, Bertrand;Mollinedo, Faustino;Momoi, Takashi;Monastyrska, Iryna;Monick, Martha M.;Monteiro, Mervyn J.;Moore, Michael N.;Mora, Rodrigo;Moreau, Kevin;Moreira, Paula I.;Moriyasu, Yuji;Moscat, Jorge;Mostowy, Serge;Mottram, Jeremy C.;Motyl, Tomasz;Moussa, Charbel E. -H.;Mueller, Sylke;Muenger, Karl;Muenz, Christian;Murphy, Leon O.;Murphy, Maureen E.;Musaro, Antonio;Mysorekar, Indira;Nagata, Eiichiro;Nagata, Kazuhiro;Nahimana, Aimable;Nair, Usha;Nakagawa, Toshiyuki;Nakahira, Kiichi;Nakano, Hiroyasu;Nakataogawa, Hitoshi;Nanjundan, Meera;Naqvi, Naweed I.;Narendra, Derek P.;Narita, Masashi;Navarro, Miguel;Nawrocki, Steffan T.;Nazarko, Taras Y.;Nemchenko, Andriy;Netea, Mihai G.;Neufeld, Thomas P.;Ney, Paul A.;Nezis, Ioannis P.;Huu Phuc Nguyen;Nie, Daotai;Nishino, Ichizo;Nislow, Corey;Nixon, Ralph A.;Noda, Takeshi;Noegel, Angelika A.;Nogalska, Anna;Noguchi, Satoru;Notterpek, Lucia;Novak, Ivana;Nozaki, Tomoyoshi;Nukina, Nobuyuki;Nuernberger, Thorsten;Nyfeler, Beat;Obara, Keisuke;Oberley, Terry D.;Oddo, Salvatore;Ogawa, Michinaga;Ohashi, Toya;Okamoto, Koji;Oleinick, Nancy L.;Oliver, F. Javier;Olsen, Laura J.;Olsson, Stefan;Opota, Onya;Osborne, Timothy F.;Ostrander, Gary K.;Otsu, Kinya;Ou, Jing-hsiung James;Ouimet, Mireille;Overholtzer, Michael;Ozpolat, Bulent;Paganetti, Paolo;Pagnini, Ugo;Pallet, Nicolas;Palmer, Glen E.;Palumbo, Camilla;Pan, Tianhong;Panaretakis, Theocharis;Pandey, Udai Bhan;Papackova, Zuzana;Papassideri, Issidora;Paris, Irmgard;Park, Junsoo;Park, Ohkmae K.;Parys, Jan B.;Parzych, Katherine R.;Patschan, Susann;Patterson, Cam;Pattingre, Sophie;Pawelek, John M.;Peng, Jianxin;Perlmutter, David H.;Perrotta, Ida;Perry, George;Pervaiz, Shazib;Peter, Matthias;Peters, Godefridus J.;Petersen, Morten;Petrovski, Goran;Phang, James M.;Piacentini, Mauro;Pierre, Philippe;Pierrefite-Carle, Valerie;Pierron, Gerard;Pinkas-Kramarski, Ronit;Piras, Antonio;Piri, Natik;Platanias, Leonidas C.;Poeggeler, Stefanie;Poirot, Marc;Poletti, Angelo;Poues, Christian;Pozuelo-Rubio, Mercedes;Praetorius-Ibba, Mette;Prasad, Anil;Prescott, Mark;Priault, Muriel;Produit-Zengaffinen, Nathalie;Progulske-Fox, Ann;Proikas-Cezanne, Tassula;Przedborski, Serge;Przyklenk, Karin;Puertollano, Rosa;Puyal, Julien;Qian, Shu-Bing;Qin, Liang;Qin, Zheng-Hong;Quaggin, Susan E.;Raben, Nina;Rabinowich, Hannah;Rabkin, Simon W.;Rahman, Irfan;Rami, Abdelhaq;Ramm, Georg;Randall, Glenn;Randow, Felix;Rao, V. Ashutosh;Rathmell, Jeffrey C.;Ravikumar, Brinda;Ray, Swapan K.;Reed, Bruce H.;Reed, John C.;Reggiori, Fulvio;Regnier-Vigouroux, Anne;Reichert, Andreas S.;Reiners, John J., Jr.;Reiter, Russel J.;Ren, Jun;Revuelta, Jose L.;Rhodes, Christopher J.;Ritis, Konstantinos;Rizzo, Elizete;Robbins, Jeffrey;Roberge, Michel;Roca, Hernan;Roccheri, Maria C.;Rocchi, Stephane;Rodemann, H. Peter;de Cordoba, Santiago Rodriguez;Rohrer, Baerbel;Roninson, Igor B.;Rosen, Kirill;Rost-Roszkowska, Magdalena M.;Rouis, Mustapha;Rouschop, Kasper M. A.;Rovetta, Francesca;Rubin, Brian P.;Rubinsztein, David C.;Ruckdeschel, Klaus;Rucker, Edmund B., III;Rudich, Assaf;Rudolf, Emil;Ruiz-Opazo, Nelson;Russo, Rossella;Rusten, Tor Erik;Ryan, Kevin M.;Ryter, Stefan W.;Sabatini, David M.;Sadoshima, Junichi;Saha, Tapas;Saitoh, Tatsuya;Sakagami, Hiroshi;Sakai, Yasuyoshi;Salekdeh, Ghasem Hoseini;Salomoni, Paolo;Salvaterra, Paul M.;Salvesen, Guy;Salvioli, Rosa;Sanchez, Anthony M. J.;Sanchez-Alcazar, Jose A.;Sanchez-Prieto, Ricardo;Sandri, Marco;Sankar, Uma;Sansanwal, Poonam;Santambrogio, Laura;Saran, Shweta;Sarkar, Sovan;Sarwal, Minnie;Sasakawa, Chihiro;Sasnauskiene, Ausra;Sass, Miklos;Sato, Ken;Sato, Miyuki;Schapira, Anthony H. V.;Scharl, Michael;Schaetzl, Hermann M.;Scheper, Wiep;Schiaffino, Stefano;Schneider, Claudio;Schneider, Marion E.;Schneider-Stock, Regine;Schoenlein, Patricia V.;Schorderet, Daniel F.;Schueller, Christoph;Schwartz, Gary K.;Scorrano, Luca;Sealy, Linda;Seglen, Per O.;Segura-Aguilar, Juan;Seiliez, Iban;Seleverstov, Oleksandr;Sell, Christian;Seo, Jong Bok;Separovic, Duska;Setaluri, Vijayasaradhi;Setoguchi, Takao;Settembre, Carmine;Shacka, John J.;Shanmugam, Mala;Shapiro, Irving M.;Shaulian, Eitan;Shaw, Reuben J.;Shelhamer, James H.;Shen, Han-Ming;Shen, Wei-Chiang;Sheng, Zu-Hang;Shi, Yang;Shibuya, Kenichi;Shidoji, Yoshihiro;Shieh, Jeng-Jer;Shih, Chwen-Ming;Shimada, Yohta;Shimizu, Shigeomi;Shintani, Takahiro;Shirihai, Orian S.;Shore, Gordon C.;Sibirny, Andriy A.;Sidhu, Stan B.;Sikorska, Beata;Silva-Zacarin, Elaine C. M.;Simmons, Alison;Simon, Anna Katharina;Simon, Hans-Uwe;Simone, Cristiano;Simonsen, Anne;Sinclair, David A.;Singh, Rajat;Sinha, Debasish;Sinicrope, Frank A.;Sirko, Agnieszka;Siu, Parco M.;Sivridis, Efthimios;Skop, Vojtech;Skulachev, Vladimir P.;Slack, Ruth S.;Smaili, Soraya S.;Smith, Duncan R.;Soengas, Maria S.;Soldati, Thierry;Song, Xueqin;Sood, Anil K.;Soong, Tuck Wah;Sotgia, Federica;Spector, Stephen A.;Spies, Claudia D.;Springer, Wolfdieter;Srinivasula, Srinivasa M.;Stefanis, Leonidas;Steffan, Joan S.;Stendel, Ruediger;Stenmark, Harald;Stephanou, Anastasis;Stern, Stephan T.;Sternberg, Cinthya;Stork, Bjoern;Stralfors, Peter;Subauste, Carlos S.;Sui, Xinbing;Sulzer, David;Sun, Jiaren;Sun, Shi-Yong;Sun, Zhi-Jun;Sung, Joseph J. Y.;Suzuki, Kuninori;Suzuki, Toshihiko;Swanson, Michele S.;Swanton, Charles;Sweeney, Sean T.;Sy, Lai-King;Szabadkai, Gyorgy;Tabas, Ira;Taegtmeyer, Heinrich;Tafani, Marco;Takacs-Vellai, Krisztina;Takano, Yoshitaka;Takegawa, Kaoru;Takemura, Genzou;Takeshita, Fumihiko;Talbot, Nicholas J.;Tan, Kevin S. W.;Tanaka, Keiji;Tanaka, Kozo;Tang, Daolin;Tang, Dingzhong;Tanida, Isei;Tannous, Bakhos A.;Tavernarakis, Nektarios;Taylor, Graham S.;Taylor, Gregory A.;Taylor, J. Paul;Terada, Lance S.;Terman, Alexei;Tettamanti, Gianluca;Thevissen, Karin;Thompson, Craig B.;Thorburn, Andrew;Thumm, Michael;Tian, FengFeng;Tian, Yuan;Tocchini-Valentini, Glauco;Tolkovsky, Aviva M.;Tomino, Yasuhiko;Toenges, Lars;Tooze, Sharon A.;Tournier, Cathy;Tower, John;Towns, Roberto;Trajkovic, Vladimir;Travassos, Leonardo H.;Tsai, Ting-Fen;Tschan, Mario P.;Tsubata, Takeshi;Tsung, Allan;Turk, Boris;Turner, Lorianne S.;Tyagi, Suresh C.;Uchiyama, Yasuo;Ueno, Takashi;Umekawa, Midori;Umemiya-Shirafuji, Rika;Unni, Vivek K.;Vaccaro, Maira I.;Valente, Enza Maria;Van den Berghe, Greet;van der Klei, Ida J.;van Doorn, Wouter G.;van Dyk, Linda F.;van Egmond, Marjolein;van Grunsven, Leo A.;Vandenabeele, Peter;Vandenberghe, Wim P.;Vanhorebeek, Ilse;Vaquero, Eva C.;Velasco, Guillermo;Vellai, Tibor;Vicencio, Jose Miguel;Vierstra, Richard D.;Vila, Miquel;Vindis, Cecile;Viola, Giampietro;Viscomi, Maria Teresa;Voitsekhovskaja, Olga V.;von Haefen, Clarissa;Votruba, Marcela;Wada, Keiji;Wade-Martins, Richard;Walker, Cheryl L.;Walsh, Craig M.;Walter, Jochen;Wan, Xiang-Bo;Wang, Aimin;Wang, Chenguang;Wang, Dawei;Wang, Fan;Wang, Fen;Wang, Guanghui;Wang, Haichao;Wang, Hong-Gang;Wang, Horng-Dar;Wang, Jin;Wang, Ke;Wang, Mei;Wang, Richard C.;Wang, Xinglong;Wang, Xuejun;Wang, Ying-Jan;Wang, Yipeng;Wang, Zhen;Wang, Zhigang Charles;Wang, Zhinong;Wansink, Derick G.;Ward, Diane M.;Watada, Hirotaka;Waters, Sarah L.;Webster, Paul;Wei, Lixin;Weihl, Conrad C.;Weiss, William A.;Welford, Scott M.;Wen, Long-Ping;Whitehouse, Caroline A.;Whitton, J. Lindsay;Whitworth, Alexander J.;Wileman, Tom;Wiley, John W.;Wilkinson, Simon;Willbold, Dieter;Williams, Roger L.;Williamson, Peter R.;Wouters, Bradly G.;Wu, Chenghan;Wu, Dao-Cheng;Wu, William K. K.;Wyttenbach, Andreas;Xavier, Ramnik J.;Xi, Zhijun;Xia, Pu;Xiao, Gengfu;Xie, Zhiping;Xie, Zhonglin;Xu, Da-zhi;Xu, Jianzhen;Xu, Liang;Xu, Xiaolei;Yamamoto, Ai;Yamamoto, Akitsugu;Yamashina, Shunhei;Yamashita, Michiaki;Yan, Xianghua;Yanagida, Mitsuhiro;Yang, Dun-Sheng;Yang, Elizabeth;Yang, Jin-Ming;Yang, Shi Yu;Yang, Wannian;Yang, Wei Yuan;Yang, Zhifen;Yao, Meng-Chao;Yao, Tso-Pang;Yeganeh, Behzad;Yen, Wei-Lien;Yin, Jia-jing;Yin, Xiao-Ming;Yoo, Ook-Joon;Yoon, Gyesoon;Yoon, Seung-Yong;Yorimitsu, Tomohiro;Yoshikawa, Yuko;Yoshimori, Tamotsu;Yoshimoto, Kohki;You, Ho Jin;Youle, Richard J.;Younes, Anas;Yu, Li;Yu, Long;Yu, Seong-Woon;Yu, Wai Haung;Yuan, Zhi-Min;Yue, Zhenyu;Yun, Cheol-Heui;Yuzaki, Michisuke;Zabirnyk, Olga;Silva-Zacarin, Elaine;Zacks, David;Zacksenhaus, Eldad;Zaffaroni, Nadia;Zakeri, Zahra;Zeh, Herbert J., III;Zeitlin, Scott O.;Zhang, Hong;Zhang, Hui-Ling;Zhang, Jianhua;Zhang, Jing-Pu;Zhang, Lin;Zhang, Long;Zhang, Ming-Yong;Zhang, Xu Dong;Zhao, Mantong;Zhao, Yi-Fang;Zhao, Ying;Zhao, Zhizhuang J.;Zheng, Xiaoxiang;Zhivotovsky, Boris;Zhong, Qing;Zhou, Cong-Zhao;Zhu, Changlian;Zhu, Wei-Guo;Zhu, Xiao-Feng;Zhu, Xiongwei;Zhu, Yuangang;Zoladek, Teresa;Zong, Wei-Xing;Zorzano, Antonio;Zschocke, Juergen;Zuckerbraun, Brian
通讯作者:
Klionsky, DJ
作者机构:
[Yang, Wei Yuan; Chen, Guang-Chao] Acad Sinica, Inst Biol Chem, Taipei, Taiwan.
[Kotake, Yaichiro] Hiroshima Univ, Grad Sch Biomed Sci, Hiroshima, Japan.
[Eskelinen, Eeva-Liisa] Univ Helsinki, Dept Biosci, Helsinki, Finland.
[Banhegyi, Gabor] Semmelweis Univ, Dept Med Chem Mol Biol & Pathobiochem, H-1085 Budapest, Hungary.
[Laszlo, Lajos; Juhasz, Gabor; Low, Peter; Kovacs, Attila L.; Sass, Miklos] Eotvos Lorand Univ, Dept Anat Cell & Dev Biol, Budapest, Hungary.
通讯机构:
[Klionsky, DJ] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA.
语种:
英文
关键词:
autolysosome;autophagosome;flux;LC3;lysosome;phagophore;stress;vacuole
期刊:
AUTOPHAGY
ISSN:
1554-8627
年:
2012
卷:
8
期:
4
页码:
445-544
文献类别:
WOS:Review
所属学科:
ESI学科类别:分子生物学&遗传学;WOS学科类别:Cell Biology
入藏号:
基金类别:
National Institutes of Health Public Health Service [GM53396]; ICREA
机构署名:
本校为其他机构
院系归属:
物理科学与技术学院
生命科学学院
化学学院
计算机学院
美术学院
摘要:
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
参考文献:
Abeliovich H, 1999, EMBO J, V18, P6005, DOI 10.1093/emboj/18.21.6005
Abeliovich H, 2011, ANTIOXID REDOX SIGN, V14, P2003, DOI 10.1089/ars.2010.3807
Abeliovich H, 2009, AUTOPHAGY, V5, P925
AHLBERG J, 1985, J BIOL CHEM, V260, P5847
Aits S, 2009, INT J CANCER, V124, P1008, DOI 10.1002/ijc.24076

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com