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Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor

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成果类型:
期刊论文
作者:
Chen, Chao-Nan;Chen, Qiong;Liu, Yu-Chao;Zhu, Xiao-Lei;Niu, Cong-Wei;...
通讯作者:
Xi, Zhen
作者机构:
[Yang, Guang-Fu; Zhu, Xiao-Lei; Liu, Yu-Chao; Chen, Qiong; Chen, Chao-Nan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
[Xi, Zhen; Niu, Cong-Wei] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China.
通讯机构:
[Xi, Zhen] N
Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China.
语种:
英文
关键词:
1,2,4-Triazolopyrimidine-2-sulfonamide;Acetohydroxyacid synthase inhibitor;Herbicide
期刊:
Bioorganic & Medicinal Chemistry
ISSN:
0968-0896
年:
2010
卷:
18
期:
14
页码:
4897-4904
基金类别:
National Basic Research Program of ChinaNational Basic Research Program of China [2010CB126103]; NSFCNational Natural Science Foundation of China (NSFC) [20925206, 20932005, 20702018]
机构署名:
本校为第一机构
院系归属:
化学学院
摘要:
The triazolopyrimidine-2-sulfonanilide, discovered from preparing bioisosteres of the sulfonylurea herbicides, is an important class of acetohydroxyacid synthase (AHAS, EC 4.1.3.18) inhibitors. At least over ten triazolopyrimidine sulfonanilides have been commercialized as herbicides for the control of broadleaf weeds and grass with cereal crop selectivity. Herein, a series of triazolopyrimidine-2-sulfonanilides were designed and synthesized with the aim of discovery of new herbicides with higher activity. The assay results of the inhibition ac...

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