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Synthesis and antitumor activity of novel dithiocarbamate substituted chromones

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成果类型:
期刊论文
作者:
Huang, Wei;Ding, Yu;Miao, Yan;Liu, Ming-Zhen;Li, Yan*;...
通讯作者:
Li, Yan
作者机构:
[Yang, Guang-Fu; Huang, Wei; Miao, Yan; Liu, Ming-Zhen; Ding, Yu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
[Li, Yan] Wuhan Univ, Zhongnan Hosp, Ctr Canc, Wuhan 430072, Peoples R China.
通讯机构:
[Li, Yan] W
Wuhan Univ, Zhongnan Hosp, Ctr Canc, Wuhan 430072, Peoples R China.
语种:
英文
关键词:
Flavonoids;Chromone;Dithiocarbamate;Antitumor activity
期刊:
European Journal of Medicinal Chemistry
ISSN:
0223-5234
年:
2009
卷:
44
期:
9
页码:
3687-3696
基金类别:
Research Fund for the Doctoral Program of Higher Education; National NSFC
机构署名:
本校为第一机构
院系归属:
化学学院
摘要:
A series of chromone derivatives bearing diverse dithiocarbamate moieties were designed and synthesized via a three-component reaction protocol. Their in vitro antitumor activities were evaluated by MTT method against HCCLM-7, Hela, MDA-MB-435S, SW-480, Hep-2 and MCF-7. Two compounds (3-chloro-4-oxo-4H-chromen-2-yl)methyl piperidine-1-carbodithioate (Iq) and (6-chloro-4-oxo-4H-chromen-3-yl)methyl piperidine-1-carbodithioate (IIu), were identified as the most promising candidate due to their high potency and broad-spectrum. Further flow-activate...

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