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Molecular Iodine-Mediated Chemoselective Synthesis of Multisubstituted Pyridines through Catabolism and Reconstruction Behavior of Natural Amino Acids

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成果类型:
期刊论文
作者:
Xiang, Jia-Chen;Wang, Miao;Cheng, Yan;Wu, An-Xin*吴安心
通讯作者:
Wu, An-Xin(吴安心
作者机构:
[Wu, An-Xin; Cheng, Yan; Wang, Miao; Xiang, Jia-Chen] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Wu, An-Xin] C
Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
语种:
英文
期刊:
Organic Letters
ISSN:
1523-7060
年:
2015
卷:
18
期:
1
页码:
24-27
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21272085, 21472056]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A new process has been developed for the selective construction of 2,6-disubstituted, 2,4,6-trisubstituted, and 3,5-disubstituted pyridines based on the catabolism and reconstruction behaviors of amino acids. Molecular iodine was used as a tandem catalyst to trigger the decarboxylation–deamination of amino acids and to promote the subsequ...

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