Hepatitis A virus cellular receptor2 (Havcr2)also named T-cell immunoglobulin and mucin domain containing-3 (Tim-3)was initially described as a T helper 1-specific cell surface protein, a member of Tim family implicated in the regulating process of adaptive and innate immune responses. Here, medaka (Oryzias latipes)Havcr2 (OlHavcr2)was isolated and characterized. Unlike other Havcr2 proteins, OlHavcr2 possesses two Ig-like domains but lacks cytoplasmic and transmembrane domains. RT-PCR results revealed that OlHavcr2 mRNA was expressed strongly ...
