Activity-Based Near-Infrared Fluorogenic Probe for Enabling in Vitro and in Vivo Profiling of Neutrophil Elastase

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成果类型：

期刊论文

作者：

Liu, Shi-Yu;Xiong, Hao;Li, Rong-Rong;Yang, Wen-Chao*;Yang, Guang-Fu*（杨光富）

通讯作者：

Yang, Wen-Chao;Yang, Guang-Fu（杨光富）

作者机构：

[Yang, Guang-Fu; Liu, Shi-Yu; Li, Rong-Rong; Xiong, Hao; Yang, Wen-Chao; Yang, WC; Yang, GF] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.

[Yang, Guang-Fu; Liu, Shi-Yu; Li, Rong-Rong; Xiong, Hao; Yang, Wen-Chao; Yang, WC; Yang, GF] Cent China Normal Univ, Coll Chem, Chem Biol Ctr, Wuhan 430079, Hubei, Peoples R China.

[Yang, Guang-Fu] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 30071, Peoples R China.

通讯机构：

[Yang, Guang-Fu; Yang, WC; Yang, GF] C

Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.

Cent China Normal Univ, Coll Chem, Chem Biol Ctr, Wuhan 430079, Hubei, Peoples R China.

Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 30071, Peoples R China.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2019

卷：

期：

页码：

3877-3884

DOI：

10.1021/acs.analchem.8b04455

基金类别：

National Key Research and Development Program of China [2017YFA0505200]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21837001, 21672079]; Hubei Province Natural Science FoundationNatural Science Foundation of Hubei Province [2018CFA072]; self-determined research funds of Central China Normal University from the colleges' basic research and operation of MOE [CCNU18ZDPY01, CCNU18TS007]

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

Neutrophil elastase (NE), a typical hematopoietic serine protease, has significant roles in inflammatory and immune responses, and thus is highly associated with various diseases such as acute lung injury (ALI) and lung cancer. Rapid and accurate measurement of NE activity in biological systems is particularly important for understanding the role of NE in inflammatory diseases, as well as clinical diagnosis. However, the specific detection and noninvasive imaging of NE in vivo remains a challenge. To address this issue, a small-molecule substra...

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Activity-Based Near-Infrared Fluorogenic Probe for Enabling in Vitro and in Vivo Profiling of Neutrophil Elastase

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