Multi-level bioinformatics resources support drug target discovery of protein–protein interactions

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Jia-Xin;Zhang, Xiao;Huang, Yuan-Qin;Hao, Ge-Fei*;Yang, Guang-Fu

通讯作者：

Hao, Ge-Fei;Yang, GF;Hao, GF

作者机构：

[Yang, Guang-Fu; Yang, GF; Liu, Jia-Xin; Hao, Ge-Fei] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.

[Zhang, Xiao; Hao, Ge-Fei; Huang, Yuan-Qin] Guizhou Univ, Ctr R&D Fine Chem, State Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China.

通讯机构：

[Hao, GF ] G

[Yang, GF ; Hao, GF] C

Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.

Guizhou Univ, Ctr R&D Fine Chem, State Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China.

语种：

英文

关键词：

binding site;drug targets;in silico;network;protein–protein interactions

期刊：

Drug Discovery Today

ISSN：

1359-6446

年：

2024

卷：

期：

页码：

103979

DOI：

10.1016/j.drudis.2024.103979

基金类别：

CRediT authorship contribution statement Jia-Xin Liu: Writing – review & editing, Writing – original draft, Software, Methodology, Formal analysis, Conceptualization. Xiao Zhang: Writing – review & editing, Visualization. Yuan-Qin Huang: Writing – review & editing. Ge-Fei Hao: Writing – review & editing. Guang-Fu Yang: Supervision, Project administration, acquisition.

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

Drug discovery often begins with a new target. Protein-protein interactions (PPIs) are crucial to multitudinous cellular processes and offer a promising avenue for drug-target discovery. PPIs are characterized by multi-level complexity: at the protein level, interaction networks can be used to identify potential targets, whereas at the residue level, the details of the interactions of individual PPIs can be used to examine a target's druggability. Much great progress has been made in target discovery through multi-level PPI-related computational approaches, but these resources have not been fu...

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Multi-level bioinformatics resources support drug target discovery of protein–protein interactions

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