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Guidelines for the use and interpretation of assays for monitoring autophagy

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期刊论文
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Klionsky, Daniel J.*;Abdalla, Fabio C.;Abeliovich, Hagai;Abraham, Robert T.;Acevedo-Arozena, Abraham;Adeli, Khosrow;Agholme, Lotta;Agnello, Maria;Agostinis, Patrizia;Aguirre-Ghiso, Julio A.;Ahn, Hyung Jun;Ait-Mohamed, Ouardia;Ait-Si-Ali, Slimane;Akematsu, Takahiko;Akira, Shizuo;Al-Younes, Hesham M.;Al-Zeer, Munir A.;Albert, Matthew L.;Albin, Roger L.;Alegre-Abarrategui, Javier;Aleo, Maria Francesca;Alirezaei, Mehrdad;Almasan, Alexandru;Almonte-Becerril, Maylin;Amano, Atsuo;Amaravadi, Ravi;Amarnath, Shoba;Amer, Amal O.;Andrieu-Abadie, Nathalie;Anantharam, Vellareddy;Ann, David K.;Anoopkumar-Dukie, Shailendra;Aoki, Hiroshi;Apostolova, Nadezda;Arancia, Giuseppe;Aris, John P.;Asanuma, Katsuhiko;Asare, Nana Y. O.;Ashida, Hisashi;Askanas, Valerie;Askew, David S.;Auberger, Patrick;Baba, Misuzu;Backues, Steven K.;Baehrecke, Eric H.;Bahr, Ben A.;Bai, Xue-Yuan;Bailly, Yannick;Baiocchi, Robert;Baldini, Giulia;Balduini, Walter;Ballabio, Andrea;Bamber, Bruce A.;Bampton, Edward T. W.;Banhegyi, Gabor;Bartholomew, Clinton R.;Bassham, Diane C.;Bast, Robert C., Jr.;Batoko, Henri;Bay, Boon-Huat;Beau, Isabelle;Bechet, Daniel M.;Begley, Thomas J.;Behl, Christian;Behrends, Christian;Bekri, Soumeya;Bellaire, Bryan;Bendall, Linda J.;Benetti, Luca;Berliocchi, Laura;Bernardi, Henri;Bernassola, Francesca;Besteiro, Sebastien;Bhatia-Kissova, Ingrid;Bi, Xiaoning;Biard-Piechaczyk, Martine;Blum, Janice S.;Boise, Lawrence H.;Bonaldo, Paolo;Boone, David L.;Bornhauser, Beat C.;Bortoluci, Karina R.;Bossis, Ioannis;Bost, Frederic;Bourquin, Jean-Pierre;Boya, Patricia;Boyer-Guittaut, Michael;Bozhkov, Peter V.;Brady, Nathan R.;Brancolini, Claudio;Brech, Andreas;Brenman, Jay E.;Brennand, Ana;Bresnick, Emery H.;Brest, Patrick;Bridges, Dave;Bristol, Molly L.;Brookes, Paul S.;Brown, Eric J.;Brumell, John H.;Brunetti-Pierri, Nicola;Brunk, Ulf T.;Bulman, Dennis E.;Bultman, Scott J.;Bultynck, Greet;Burbulla, Lena F.;Bursch, Wilfried;Butchar, Jonathan P.;Buzgariu, Wanda;Bydlowski, Sergio P.;Cadwell, Ken;Cahova, Monika;Cai, Dongsheng;Cai, Jiyang;Cai, Qian;Calabretta, Bruno;Calvo-Garrido, Javier;Camougrand, Nadine;Campanella, Michelangelo;Campos-Salinas, Jenny;Candi, Eleonora;Cao, Lizhi;Caplan, Allan B.;Carding, Simon R.;Cardoso, Sandra M.;Carew, Jennifer S.;Carlin, Cathleen R.;Carmignac, Virgine;Carneiro, Leticia A. M.;Carra, Serena;Caruso, Rosario A.;Casari, Giorgio;Casas, Caty;Castino, Roberta;Cebollero, Eduardo;Cecconi, Francesco;Celli, Jean;Chaachouay, Hassan;Chae, Han-Jung;Chai, Chee-Yin;Chan, David C.;Chan, Edmond Y.;Chang, Raymond Chuen-Chung;Che, Chi-Ming;Chen, Ching-Chow;Chen, Guang-Chao;Chen, Guo-Qiang;Chen, Min;Chen, Quan;Chen, Steve S. -L.;Chen, WenLi;Chen, Xi;Chen, Xiangmei;Chen, Xiequn;Chen, Ye-Guang;Chen, Yingyu;Chen, Yongqiang;Chen, Yu-Jen;Chen, Zhixiang;Cheng, Alan;Cheng, Christopher H. K.;Cheng, Yan;Cheong, Heesun;Cheong, Jae-Ho;Cherry, Sara;Chess-Williams, Russ;Cheung, Zelda H.;Chevet, Eric;Chiang, Hui-Ling;Chiarelli, Roberto;Chiba, Tomoki;Chin, Lih-Shen;Chiou, Shih-Hwa;Chisari, Francis V.;Cho, Chi Hin;Cho, Dong-Hyung;Choi, Augustine M. K.;Choi, DooSeok;Choi, Kyeong Sook;Choi, Mary E.;Chouaib, Salem;Choubey, Divaker;Choubey, Vinay;Chu, Charleen T.;Chuang, Tsung-Hsien;Chueh, Sheau-Huei;Chun, Taehoon;Chwae, Yong-Joon;Chye, Mee-Len;Ciarcia, Roberto;Ciriolo, Maria R.;Clague, Michael J.;Clark, Robert S. B.;Clarke, Peter G. H.;Clarke, Robert;Codogno, Patrice;Coller, Hilary A.;Colombo, Maria I.;Comincini, Sergio;Condello, Maria;Condorelli, Fabrizio;Cookson, Mark R.;Coppens, Graham H. Coombs Isabelle;Corbalan, Ramon;Cossart, Pascale;Costelli, Paola;Costes, Safia;Coto-Montes, Ana;Couve, Eduardo;Coxon, Fraser P.;Cregg, James M.;Crespo, Jose L.;Cronje, Marianne J.;Cuervo, Ana Maria;Cullen, Joseph J.;Czaja, Mark J.;D'Amelio, Marcello;Darfeuille-Michaud, Arlette;Davids, Lester M.;Davies, Faith E.;De Felici, Massimo;de Groot, John F.;de Haan, Cornelis A. M.;De Martino, Luisa;De Milito, Angelo;De Tata, Vincenzo;Debnath, Jayanta;Degterev, Alexei;Dehay, Benjamin;Delbridge, Lea M. D.;Demarchi, Francesca;Deng, Yi Zhen;Dengjel, Joen;Dent, Paul;Denton, Donna;Deretic, Vojo;Desai, Shyamal D.;Devenish, Rodney J.;Di Gioacchino, Mario;Di Paolo, Gilbert;Di Pietro, Chiara;Diaz-Araya, Guillermo;Diaz-Laviada, Ines;Diaz-Meco, Maria T.;Diaz-Nido, Javier;Dikic, Ivan;Dinesh-Kumar, Savithramma P.;Ding, Wen-Xing;Distelhorst, Clark W.;Diwan, Abhinav;Djavaheri-Mergny, Mojgan;Dokudovskaya, Svetlana;Dong, Zheng;Dorsey, Frank C.;Dosenko, Victor;Dowling, James J.;Doxsey, Stephen;Dreux, Marlene;Drew, Mark E.;Duan, Qiuhong;Duchosal, Michel A.;Duff, Karen;Dugail, Isabelle;Durbeej, Madeleine;Duszenko, Michael;Edelstein, Charles L.;Edinger, Aimee L.;Egea, Gustavo;Eichinger, Ludwig;Eissa, N. Tony;Ekmekcioglu, Suhendan;El-Deiry, Wafik S.;Elazar, Zvulun;Elgendy, Mohamed;Ellerby, Lisa M.;Eng, Kai Er;Engelbrecht, Anna-Mart;Engelender, Simone;Erenpreisa, Jekaterina;Escalante, Ricardo;Esclatine, Audrey;Eskelinen, Eeva-Liisa;Espert, Lucile;Espina, Virginia;Fan, Huizhou;Fan, Jia;Fan, Qi-Wen;Fan, Zhen;Fang, Shengyun;Fang, Yongqi;Fanto, Manolis;Fanzani, Alessandro;Farkas, Thomas;Farre, Jean-Claude;Faure, Mathias;Fechheimer, Marcus;Feng, Carl G.;Feng, Jian;Feng, Qili;Feng, Youji;Fesues, Laszlo;Feuer, Ralph;Figueiredo-Pereira, Maria E.;Fimia, Gian Maria;Fingar, Diane C.;Finkbeiner, Steven;Finkel, Toren;Finley, Kim D.;Fiorito, Filomena;Fisher, Edward A.;Fisher, Paul B.;Flajolet, Marc;Florez-McClure, Maria L.;Florio, Salvatore;Fon, Edward A.;Fornai, Francesco;Fortunato, Franco;Fotedar, Rati;Fowler, Daniel H.;Fox, Howard S.;Franco, Rodrigo;Frankel, Lisa B.;Fransen, Marc;Fuentes, Jose M.;Fueyo, Juan;Fujii, Jun;Fujisaki, Kozo;Fujita, Eriko;Fukuda, Mitsunori;Furukawa, Ruth H.;Gaestel, Matthias;Gailly, Philippe;Gajewska, Malgorzata;Galliot, Brigitte;Galy, Vincent;Ganesh, Subramaniam;Ganetzky, Barry;Ganley, Ian G.;Gao, Fen-Biao;Gao, George F.;Gao, Jinming;Garcia, Lorena;Garcia-Manero, Guillermo;Garcia-Marcos, Mikel;Garmyn, Marjan;Gartel, Andrei L.;Gatti, Evelina;Gautel, Mathias;Gawriluk, Thomas R.;Gegg, Matthew E.;Geng, Jiefei;Germain, Marc;Gestwicki, Jason E.;Gewirtz, David A.;Ghavami, Saeid;Ghosh, Pradipta;Giammarioli, Anna M.;Giatromanolaki, Alexandra N.;Gibson, Spencer B.;Gilkerson, Robert W.;Ginger, Michael L.;Ginsberg, Henry N.;Golab, Jakub;Goligorsky, Michael S.;Golstein, Pierre;Gomez-Manzano, Candelaria;Goncu, Ebru;Gongora, Celine;Gonzalez, Claudio D.;Gonzalez, Ramon;Gonzalez-Estevez, Cristina;Gonzalez-Polo, Rosa Ana;Gonzalez-Rey, Elena;Gorbunov, Nikolai V.;Gorski, Sharon;Goruppi, Sandro;Gottlieb, Roberta A.;Gozuacik, Devrim;Granato, Giovanna Elvira;Grant, Gary D.;Green, Kim N.;Gregorc, Ales;Gros, Frederic;Grose, Charles;Grunt, Thomas W.;Gual, Philippe;Guan, Jun-Lin;Guan, Kun-Liang;Guichard, Sylvie M.;Gukovskaya, Anna S.;Gukovsky, Ilya;Gunst, Jan;Gustafsson, Asa B.;Halayko, Andrew J.;Hale, Amber N.;Halonen, Sandra K.;Hamasaki, Maho;Han, Feng;Han, Ting;Hancock, Michael K.;Hansen, Malene;Harada, Hisashi;Harada, Masaru;Hardt, Stefan E.;Harper, J. Wade;Harris, Adrian L.;Harris, James;Harris, Steven D.;Hashimoto, Makoto;Haspel, Jeffrey A.;Hayashi, Shin-ichiro;Hazelhurst, Lori A.;He, Congcong;He, You-Wen;Hebert, Marie-Josee;Heidenreich, Kim A.;Helfrich, Miep H.;Helgason, Gudmundur V.;Henske, Elizabeth P.;Herman, Brian;Herman, Paul K.;Hetz, Claudio;Hilfiker, Sabine;Hill, Joseph A.;Hocking, Lynne J.;Hofman, Paul;Hofmann, Thomas G.;Hoehfeld, Joerg;Holyoake, Tessa L.;Hong, Ming-Huang;Hood, David A.;Hotamisligil, Goekhan S.;Houwerzijl, Ewout J.;Hoyer-Hansen, Maria;Hu, Bingren;Hu, Chien-An A.;Hu, Hong-Ming;Hua, Ya;Huang, Canhua;Huang, Ju;Huang, Shengbing;Huang, Wei-Pang;Huber, Tobias B.;Huh, Won-Ki;Hung, Tai-Ho;Hupp, Ted R.;Hur, Gang Min;Hurley, James B.;Hussain, Sabah N. A.;Hussey, Patrick J.;Hwang, Jung Jin;Hwang, Seungmin;Ichihara, Atsuhiro;Ilkhanizadeh, Shirin;Inoki, Ken;Into, Takeshi;Iovane, Valentine;Iovanna, Juan L.;Ip, Nancy Y.;Isaka, Yoshitaka;Ishida, Hiroyuki;Isidoro, Ciro;Isobe, Ken-ichi;Iwasaki, Akiko;Izquierdo, Marta;Izumi, Yotaro;Jaakkola, Panu M.;Jaattela, Marja;Jackson, George R.;Jackson, William T.;Janji, Bassam;Jendrach, Marina;Jeon, Ju-Hong;Jeung, Eui-Bae;Jiang, Hong;Jiang, Hongchi;Jiang, Jean X.;Jiang, Ming;Jiang, Qing;Jiang, Xuejun;Jimenez, Alberto;Jin, Meiyan;Jin, Shengkan;Joe, Cheol O.;Johansen, Terje;Johnson, Daniel E.;Johnson, Gail V. W.;Jones, Nicola L.;Joseph, Bertrand;Joseph, Suresh K.;Joubert, Annie M.;Juhasz, Gabor;Juillerat-Jeanneret, Lucienne;Jung, Chang Hwa;Jung, Yong-Keun;Kaarniranta, Kai;Kaasik, Allen;Kabuta, Tomohiro;Kadowaki, Motoni;Kagedal, Katarina;Kamada, Yoshiaki;Kaminskyy, Vitaliy O.;Kampinga, Harm H.;Kanamori, Hiromitsu;Kang, Chanhee;Kang, Khong Bee;Kang, Kwang Il;Kang, Rui;Kang, Yoon-A;Kanki, Tomotake;Kanneganti, Thirumala-Devi;Kanno, Haruo;Kanthasamy, Anumantha G.;Kanthasamy, Arthi;Karantza, Vassiliki;Kaushal, Gur P.;Kaushik, Susmita;Kawazoe, Yoshinori;Ke, Po-Yuan;Kehrl, John H.;Kelekar, Ameeta;Kerkhoff, Claus;Kessel, David H.;Khalil, Hany;Kiel, Jan A. K. W.;Kiger, Amy A.;Kihara, Akio;Kim, Deok Ryong;Kim, Do-Hyung;Kim, Dong-Hou;Kim, Eun-Kyoung;Kim, Hyung-Ryong;Kim, Jae-Sung;Kim, Jeong Hun;Kim, Jin Cheon;Kim, John K.;Kim, Peter K.;Kim, Seong Who;Kim, Yong-Sun;Kim, Yonghyun;Kimchi, Adi;Kimmelman, Alec C.;King, Jason S.;Kinsella, Timothy J.;Kirkin, Vladimir;Kirshenbaum, Lorrie A.;Kitamoto, Katsuhiko;Kitazato, Kaio;Klein, Ludger;Klimecki, Walter T.;Klucken, Jochen;Knecht, Erwin;Ko, Ben C. B.;Koch, Jan C.;Koga, Hiroshi;Koh, Jae-Young;Koh, Young Ho;Koike, Masato;Komatsu, Masaaki;Kominami, Eiki;Kong, Hee Jeong;Kong, Wei-Jia;Korolchuk, Viktor I.;Kotake, Yaichiro;Koukourakis, Michael I.;Flores, Juan B. Kouri;Kovacs, Attila L.;Kraft, Claudine;Krainc, Dimitri;Kraemer, Helmut;Kretz-Remy, Carole;Krichevsky, Anna M.;Kroemer, Guido;Krueger, Rejko;Krut, Oleg;Ktistakis, Nicholas T.;Kuan, Chia-Yi;Kucharczyk, Roza;Kumar, Ashok;Kumar, Raj;Kumar, Sharad;Kundu, Mondira;Kung, Hsing-Jien;Kurz, Tino;Kwon, Ho Jeong;La Spada, Albert R.;Lafont, Frank;Lamark, Trond;Landry, Jacques;Lane, Jon D.;Lapaquette, Pierre;Laporte, Jocelyn F.;Laszlo, Lajos;Lavandero, Sergio;Lavoie, Josee N.;Layfield, Robert;Lazo, Pedro A.;Le, Weidong;Le Cam, Laurent;Ledbetter, Daniel J.;Lee, Alvin J. 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Angus;Meijer, Alfred J.;Meisler, Miriam H.;Melendez, Alicia;Melia, Thomas J.;Melino, Gerry;Mena, Maria A.;Menendez, Javier A.;Menna-Barreto, Rubem F. S.;Menon, Manoj B.;Menzies, Fiona M.;Mercer, Carol A.;Merighi, Adalberto;Merry, Diane E.;Meschini, Stefania;Meyer, Christian G.;Meyer, Thomas F.;Miao, Chao-Yu;Miao, Jun-Ying;Michels, Paul A. M.;Michiels, Carine;Mijaljica, Dalibor;Milojkovic, Ana;Minucci, Saverio;Miracco, Clelia;Miranti, Cindy K.;Mitroulis, Ioannis;Miyazawa, Keisuke;Mizushima, Noboru;Mograbi, Baharia;Mohseni, Simin;Molero, Xavier;Mollereau, Bertrand;Mollinedo, Faustino;Momoi, Takashi;Monastyrska, Iryna;Monick, Martha M.;Monteiro, Mervyn J.;Moore, Michael N.;Mora, Rodrigo;Moreau, Kevin;Moreira, Paula I.;Moriyasu, Yuji;Moscat, Jorge;Mostowy, Serge;Mottram, Jeremy C.;Motyl, Tomasz;Moussa, Charbel E. -H.;Mueller, Sylke;Muenger, Karl;Muenz, Christian;Murphy, Leon O.;Murphy, Maureen E.;Musaro, Antonio;Mysorekar, Indira;Nagata, Eiichiro;Nagata, Kazuhiro;Nahimana, Aimable;Nair, Usha;Nakagawa, Toshiyuki;Nakahira, Kiichi;Nakano, Hiroyasu;Nakataogawa, Hitoshi;Nanjundan, Meera;Naqvi, Naweed I.;Narendra, Derek P.;Narita, Masashi;Navarro, Miguel;Nawrocki, Steffan T.;Nazarko, Taras Y.;Nemchenko, Andriy;Netea, Mihai G.;Neufeld, Thomas P.;Ney, Paul A.;Nezis, Ioannis P.;Huu Phuc Nguyen;Nie, Daotai;Nishino, Ichizo;Nislow, Corey;Nixon, Ralph A.;Noda, Takeshi;Noegel, Angelika A.;Nogalska, Anna;Noguchi, Satoru;Notterpek, Lucia;Novak, Ivana;Nozaki, Tomoyoshi;Nukina, Nobuyuki;Nuernberger, Thorsten;Nyfeler, Beat;Obara, Keisuke;Oberley, Terry D.;Oddo, Salvatore;Ogawa, Michinaga;Ohashi, Toya;Okamoto, Koji;Oleinick, Nancy L.;Oliver, F. Javier;Olsen, Laura J.;Olsson, Stefan;Opota, Onya;Osborne, Timothy F.;Ostrander, Gary K.;Otsu, Kinya;Ou, Jing-hsiung James;Ouimet, Mireille;Overholtzer, Michael;Ozpolat, Bulent;Paganetti, Paolo;Pagnini, Ugo;Pallet, Nicolas;Palmer, Glen E.;Palumbo, Camilla;Pan, Tianhong;Panaretakis, Theocharis;Pandey, Udai Bhan;Papackova, Zuzana;Papassideri, Issidora;Paris, Irmgard;Park, Junsoo;Park, Ohkmae K.;Parys, Jan B.;Parzych, Katherine R.;Patschan, Susann;Patterson, Cam;Pattingre, Sophie;Pawelek, John M.;Peng, Jianxin;Perlmutter, David H.;Perrotta, Ida;Perry, George;Pervaiz, Shazib;Peter, Matthias;Peters, Godefridus J.;Petersen, Morten;Petrovski, Goran;Phang, James M.;Piacentini, Mauro;Pierre, Philippe;Pierrefite-Carle, Valerie;Pierron, Gerard;Pinkas-Kramarski, Ronit;Piras, Antonio;Piri, Natik;Platanias, Leonidas C.;Poeggeler, Stefanie;Poirot, Marc;Poletti, Angelo;Poues, Christian;Pozuelo-Rubio, Mercedes;Praetorius-Ibba, Mette;Prasad, Anil;Prescott, Mark;Priault, Muriel;Produit-Zengaffinen, Nathalie;Progulske-Fox, Ann;Proikas-Cezanne, Tassula;Przedborski, Serge;Przyklenk, Karin;Puertollano, Rosa;Puyal, Julien;Qian, Shu-Bing;Qin, Liang;Qin, Zheng-Hong;Quaggin, Susan E.;Raben, Nina;Rabinowich, Hannah;Rabkin, Simon W.;Rahman, Irfan;Rami, Abdelhaq;Ramm, Georg;Randall, Glenn;Randow, Felix;Rao, V. Ashutosh;Rathmell, Jeffrey C.;Ravikumar, Brinda;Ray, Swapan K.;Reed, Bruce H.;Reed, John C.;Reggiori, Fulvio;Regnier-Vigouroux, Anne;Reichert, Andreas S.;Reiners, John J., Jr.;Reiter, Russel J.;Ren, Jun;Revuelta, Jose L.;Rhodes, Christopher J.;Ritis, Konstantinos;Rizzo, Elizete;Robbins, Jeffrey;Roberge, Michel;Roca, Hernan;Roccheri, Maria C.;Rocchi, Stephane;Rodemann, H. Peter;de Cordoba, Santiago Rodriguez;Rohrer, Baerbel;Roninson, Igor B.;Rosen, Kirill;Rost-Roszkowska, Magdalena M.;Rouis, Mustapha;Rouschop, Kasper M. A.;Rovetta, Francesca;Rubin, Brian P.;Rubinsztein, David C.;Ruckdeschel, Klaus;Rucker, Edmund B., III;Rudich, Assaf;Rudolf, Emil;Ruiz-Opazo, Nelson;Russo, Rossella;Rusten, Tor Erik;Ryan, Kevin M.;Ryter, Stefan W.;Sabatini, David M.;Sadoshima, Junichi;Saha, Tapas;Saitoh, Tatsuya;Sakagami, Hiroshi;Sakai, Yasuyoshi;Salekdeh, Ghasem Hoseini;Salomoni, Paolo;Salvaterra, Paul M.;Salvesen, Guy;Salvioli, Rosa;Sanchez, Anthony M. J.;Sanchez-Alcazar, Jose A.;Sanchez-Prieto, Ricardo;Sandri, Marco;Sankar, Uma;Sansanwal, Poonam;Santambrogio, Laura;Saran, Shweta;Sarkar, Sovan;Sarwal, Minnie;Sasakawa, Chihiro;Sasnauskiene, Ausra;Sass, Miklos;Sato, Ken;Sato, Miyuki;Schapira, Anthony H. V.;Scharl, Michael;Schaetzl, Hermann M.;Scheper, Wiep;Schiaffino, Stefano;Schneider, Claudio;Schneider, Marion E.;Schneider-Stock, Regine;Schoenlein, Patricia V.;Schorderet, Daniel F.;Schueller, Christoph;Schwartz, Gary K.;Scorrano, Luca;Sealy, Linda;Seglen, Per O.;Segura-Aguilar, Juan;Seiliez, Iban;Seleverstov, Oleksandr;Sell, Christian;Seo, Jong Bok;Separovic, Duska;Setaluri, Vijayasaradhi;Setoguchi, Takao;Settembre, Carmine;Shacka, John J.;Shanmugam, Mala;Shapiro, Irving M.;Shaulian, Eitan;Shaw, Reuben J.;Shelhamer, James H.;Shen, Han-Ming;Shen, Wei-Chiang;Sheng, Zu-Hang;Shi, Yang;Shibuya, Kenichi;Shidoji, Yoshihiro;Shieh, Jeng-Jer;Shih, Chwen-Ming;Shimada, Yohta;Shimizu, Shigeomi;Shintani, Takahiro;Shirihai, Orian S.;Shore, Gordon C.;Sibirny, Andriy A.;Sidhu, Stan B.;Sikorska, Beata;Silva-Zacarin, Elaine C. M.;Simmons, Alison;Simon, Anna Katharina;Simon, Hans-Uwe;Simone, Cristiano;Simonsen, Anne;Sinclair, David A.;Singh, Rajat;Sinha, Debasish;Sinicrope, Frank A.;Sirko, Agnieszka;Siu, Parco M.;Sivridis, Efthimios;Skop, Vojtech;Skulachev, Vladimir P.;Slack, Ruth S.;Smaili, Soraya S.;Smith, Duncan R.;Soengas, Maria S.;Soldati, Thierry;Song, Xueqin;Sood, Anil K.;Soong, Tuck Wah;Sotgia, Federica;Spector, Stephen A.;Spies, Claudia D.;Springer, Wolfdieter;Srinivasula, Srinivasa M.;Stefanis, Leonidas;Steffan, Joan S.;Stendel, Ruediger;Stenmark, Harald;Stephanou, Anastasis;Stern, Stephan T.;Sternberg, Cinthya;Stork, Bjoern;Stralfors, Peter;Subauste, Carlos S.;Sui, Xinbing;Sulzer, David;Sun, Jiaren;Sun, Shi-Yong;Sun, Zhi-Jun;Sung, Joseph J. Y.;Suzuki, Kuninori;Suzuki, Toshihiko;Swanson, Michele S.;Swanton, Charles;Sweeney, Sean T.;Sy, Lai-King;Szabadkai, Gyorgy;Tabas, Ira;Taegtmeyer, Heinrich;Tafani, Marco;Takacs-Vellai, Krisztina;Takano, Yoshitaka;Takegawa, Kaoru;Takemura, Genzou;Takeshita, Fumihiko;Talbot, Nicholas J.;Tan, Kevin S. W.;Tanaka, Keiji;Tanaka, Kozo;Tang, Daolin;Tang, Dingzhong;Tanida, Isei;Tannous, Bakhos A.;Tavernarakis, Nektarios;Taylor, Graham S.;Taylor, Gregory A.;Taylor, J. Paul;Terada, Lance S.;Terman, Alexei;Tettamanti, Gianluca;Thevissen, Karin;Thompson, Craig B.;Thorburn, Andrew;Thumm, Michael;Tian, FengFeng;Tian, Yuan;Tocchini-Valentini, Glauco;Tolkovsky, Aviva M.;Tomino, Yasuhiko;Toenges, Lars;Tooze, Sharon A.;Tournier, Cathy;Tower, John;Towns, Roberto;Trajkovic, Vladimir;Travassos, Leonardo H.;Tsai, Ting-Fen;Tschan, Mario P.;Tsubata, Takeshi;Tsung, Allan;Turk, Boris;Turner, Lorianne S.;Tyagi, Suresh C.;Uchiyama, Yasuo;Ueno, Takashi;Umekawa, Midori;Umemiya-Shirafuji, Rika;Unni, Vivek K.;Vaccaro, Maira I.;Valente, Enza Maria;Van den Berghe, Greet;van der Klei, Ida J.;van Doorn, Wouter G.;van Dyk, Linda F.;van Egmond, Marjolein;van Grunsven, Leo A.;Vandenabeele, Peter;Vandenberghe, Wim P.;Vanhorebeek, Ilse;Vaquero, Eva C.;Velasco, Guillermo;Vellai, Tibor;Vicencio, Jose Miguel;Vierstra, Richard D.;Vila, Miquel;Vindis, Cecile;Viola, Giampietro;Viscomi, Maria Teresa;Voitsekhovskaja, Olga V.;von Haefen, Clarissa;Votruba, Marcela;Wada, Keiji;Wade-Martins, Richard;Walker, Cheryl L.;Walsh, Craig M.;Walter, Jochen;Wan, Xiang-Bo;Wang, Aimin;Wang, Chenguang;Wang, Dawei;Wang, Fan;Wang, Fen;Wang, Guanghui;Wang, Haichao;Wang, Hong-Gang;Wang, Horng-Dar;Wang, Jin;Wang, Ke;Wang, Mei;Wang, Richard C.;Wang, Xinglong;Wang, Xuejun;Wang, Ying-Jan;Wang, Yipeng;Wang, Zhen;Wang, Zhigang Charles;Wang, Zhinong;Wansink, Derick G.;Ward, Diane M.;Watada, Hirotaka;Waters, Sarah L.;Webster, Paul;Wei, Lixin;Weihl, Conrad C.;Weiss, William A.;Welford, Scott M.;Wen, Long-Ping;Whitehouse, Caroline A.;Whitton, J. Lindsay;Whitworth, Alexander J.;Wileman, Tom;Wiley, John W.;Wilkinson, Simon;Willbold, Dieter;Williams, Roger L.;Williamson, Peter R.;Wouters, Bradly G.;Wu, Chenghan;Wu, Dao-Cheng;Wu, William K. K.;Wyttenbach, Andreas;Xavier, Ramnik J.;Xi, Zhijun;Xia, Pu;Xiao, Gengfu;Xie, Zhiping;Xie, Zhonglin;Xu, Da-zhi;Xu, Jianzhen;Xu, Liang;Xu, Xiaolei;Yamamoto, Ai;Yamamoto, Akitsugu;Yamashina, Shunhei;Yamashita, Michiaki;Yan, Xianghua;Yanagida, Mitsuhiro;Yang, Dun-Sheng;Yang, Elizabeth;Yang, Jin-Ming;Yang, Shi Yu;Yang, Wannian;Yang, Wei Yuan;Yang, Zhifen;Yao, Meng-Chao;Yao, Tso-Pang;Yeganeh, Behzad;Yen, Wei-Lien;Yin, Jia-jing;Yin, Xiao-Ming;Yoo, Ook-Joon;Yoon, Gyesoon;Yoon, Seung-Yong;Yorimitsu, Tomohiro;Yoshikawa, Yuko;Yoshimori, Tamotsu;Yoshimoto, Kohki;You, Ho Jin;Youle, Richard J.;Younes, Anas;Yu, Li;Yu, Long;Yu, Seong-Woon;Yu, Wai Haung;Yuan, Zhi-Min;Yue, Zhenyu;Yun, Cheol-Heui;Yuzaki, Michisuke;Zabirnyk, Olga;Silva-Zacarin, Elaine;Zacks, David;Zacksenhaus, Eldad;Zaffaroni, Nadia;Zakeri, Zahra;Zeh, Herbert J., III;Zeitlin, Scott O.;Zhang, Hong;Zhang, Hui-Ling;Zhang, Jianhua;Zhang, Jing-Pu;Zhang, Lin;Zhang, Long;Zhang, Ming-Yong;Zhang, Xu Dong;Zhao, Mantong;Zhao, Yi-Fang;Zhao, Ying;Zhao, Zhizhuang J.;Zheng, Xiaoxiang;Zhivotovsky, Boris;Zhong, Qing;Zhou, Cong-Zhao;Zhu, Changlian;Zhu, Wei-Guo;Zhu, Xiao-Feng;Zhu, Xiongwei;Zhu, Yuangang;Zoladek, Teresa;Zong, Wei-Xing;Zorzano, Antonio;Zschocke, Juergen;Zuckerbraun, Brian
通讯作者:
Klionsky, Daniel J.
作者机构:
[Brech, Andreas; Bridges, Dave; Lynch-Day, Melinda A.; Kim, John K.; Backues, Steven K.; Mao, Kai; Parzych, Katherine R.; Lin, Jiandie D.; Umekawa, Midori; Zhao, Mantong; Wang, Ke; Klionsky, Daniel J.; Gestwicki, Jason E.; Yen, Wei-Lien; Han, Ting; Bartholomew, Clinton R.; Jin, Meiyan; Nair, Usha] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA.
[Lynch-Day, Melinda A.; Mao, Kai; Olsen, Laura J.; Parzych, Katherine R.; Zhao, Mantong; Wang, Ke; Jin, Meiyan] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA.
[Gestwicki, Jason E.] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA.
[Marcondes, Mateus; Abdalla, Fabio C.; Silva-Zacarin, Elaine; Silva-Zacarin, Elaine C. M.] Fed Univ Sao Carlos UFSCar, Lab Struct & Funct Biol, Sao Carlos, SP, Brazil.
[Abeliovich, Hagai] Hebrew Univ Jerusalem, Dept Biochem & Food Sci, IL-76100 Rehovot, Israel.
通讯机构:
[Klionsky, Daniel J.] U
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA.
语种:
英文
关键词:
Autolysosome;Autophagosome;Flux;LC3;Lysosome;Phagophore;Stress;Vacuole
期刊:
Autophagy
ISSN:
1554-8627
年:
2012
卷:
8
期:
4
页码:
445-544
基金类别:
National Institutes of Health Public Health ServiceUnited States Public Health ServiceUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [GM53396]; Austrian Science Fund (FWF)Austrian Science Fund (FWF) [P 23490] Funding Source: researchfish; Biotechnology and Biological Sciences Research CouncilUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/I013695/1, BBS/E/F/00044446, BBS/E/B/00001221, BB/E018521/1, BB/F012861/1, BB/G021422/1, BBS/E/F/00042262] Funding Source: researchfish; Cancer Research UKCancer Research UK [15816, 12825, 15153, 15890, 12103, 11359] Funding Source: researchfish; Lundbeck FoundationLundbeckfonden [R100-2011-8756] Funding Source: researchfish; Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC) [MC_UU_12010/7, MC_UP_A500_1019, G0601840, G0700949, G1002610, MC_U105170648, G0700127, G0600251, G0600782, MC_U142684172, MC_U142684175, MC_U105184308, MC_U132670600, G0000508, MC_U132670601] Funding Source: researchfish; National Institute for Health ResearchNational Institute for Health Research (NIHR) [NF-SI-0611-10163] Funding Source: researchfish; Natural Environment Research CouncilUK Research & Innovation (UKRI)NERC Natural Environment Research Council [pml010004] Funding Source: researchfish; Novo Nordisk FondenNovo Nordisk Foundation [NNF12OC1016434] Funding Source: researchfish; Parkinson"s UKParkinson's UK [G-0905, J-0901] Funding Source: researchfish; Versus ArthritisVersus Arthritis [19379, 17655, 17285] Funding Source: researchfish; The Brain Tumour Charity [8/47] Funding Source: researchfish; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [K08CA164047, R01CA102184, R01CA159314, R01CA139319, R01CA139319, R01CA143811, R01CA137260, R01CA109182, R01CA133228, R01CA150214, R01CA157490, R01CA150214, R01CA109182, R01CA139319, R01CA142862, K08CA164047, R01CA109182, R01CA157490, R01CA109182, R01CA129536, R01CA140964, R01CA138641, R01CA134530, R01CA100857, R01CA102184, R01CA142862, R01CA159314, R01CA142862, R01CA129536, R01CA154835, R01CA129536, R01CA140964, R01CA157490, R01CA129536, R01CA129536, R01CA109182, R01CA154835, R01CA109182, R01CA100857, R01CA133228, R01CA138641, R01CA137260, R01CA103632, R01CA157490, R01CA143811, R01CA143811, R01CA141703, R01CA154835, R01CA102184, R01CA141703, R01CA102184, R01CA134530, R01CA157490, R01CA129536, R01CA157490, R01CA143811, R01CA102184, R01CA137260, R01CA102184, R01CA143811, R01CA103632, R01CA109182, R01CA102184, R01CA129536, R01CA133228, R01CA100857, R01CA150214, R01CA162405, R01CA100857, R01CA100857, R01CA109182, R01CA140964, R01CA143811, R01CA140964, R01CA137260, R01CA123350, R01CA159314, R01CA137260, R01CA134530, R01CA123350, R01CA100857, R01CA103632, R01CA154835, R01CA100857, R01CA109182, R01CA134530, R01CA138641, R01CA143811, R01CA139319, R01CA103632, R01CA109182, K05CA142885, R01CA138641, R01CA102184, K05CA142885, R01CA139319, R01CA141703, R01CA139319, R01CA157490, R01CA123350, R01CA139319, R01CA143811, R01CA129536, K08CA164047, R01CA129536, R01CA162405, R01CA142862, R01CA102184, R01CA100857, R01CA123350, R01CA140964, R01CA154835, R01CA159314, K05CA142885, R01CA141703, R01CA109182, R01CA109182, R01CA133228, R01CA103632, R01CA100857, R01CA140964, R01CA100857, R01CA103632, R01CA123350, R01CA162405, R01CA131188, R01CA100857, R01CA131188, R01CA140964, R01CA133228, R01CA103632, R01CA100857, K08CA164047, R01CA109182, R01CA143811, R01CA162405, R01CA140964, R01CA129536, R01CA100857, R01CA129536, R01CA102184, R01CA159314, R01CA109182, R01CA103632, R01CA141703, R01CA162405, R01CA103632, R01CA100857, R01CA139319, R01CA129536, R01CA100857, R01CA102184, R01CA139319, R01CA100857, R01CA138641, K05CA142885, R01CA157490, R01CA100857, R01CA131188, R01CA142862, K05CA142885, R01CA129536, R01CA140964, R01CA143811, R01CA100857, R01CA150214, R01CA131188, R01CA131188, R01CA134530, R01CA109182, R01CA133228, R01CA154835, R01CA102184, R01CA109182, R01CA154835, K08CA164047, R01CA102184, R01CA139319, R01CA150214, R01CA140964] Funding Source: NIH RePORTER; NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR000005, UL1TR000005, UL1TR000005, UL1TR000005, UL1TR000005, UL1TR000005] Funding Source: NIH RePORTER; NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01AT005076, R01AT005076] Funding Source: NIH RePORTER; NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01AT005076, R01AT005076] Funding Source: NIH RePORTER; National Center for Complementary & Integrative HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01AT005076, R01AT005076, R01AT005076, R01AT005076] Funding Source: NIH RePORTER; NATIONAL CENTER FOR RESEARCH RESOURCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Research Resources (NCRR) [S10RR025596] Funding Source: NIH RePORTER; NATIONAL EYE INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Eye Institute (NEI) [R01EY020491, R01EY009083, R01EY009083, R01EY009083, R01EY009083, R01EY009083, R01EY009083, R01EY009083, R01EY020491, R01EY009083, R01EY009083, R01EY009083, R01EY009083, R01EY009083, R01EY009083, R01EY020491, R01EY020491, R01EY019320, R01EY009083, R01EY009083, R01EY019320, R01EY019320, R01EY009083, R01EY009083, R01EY009083, R01EY020491, R01EY009083, R01EY019320, R01EY009083, R01EY009083, R01EY009083, R01EY019320, R01EY009083, R01EY009083, R01EY009083, R01EY009083, R01EY009083, R01EY009083, R01EY019320, R01EY009083, R01EY009083, R01EY009083, R01EY009083] Funding Source: NIH RePORTER; NATIONAL HEART, LUNG, AND BLOOD INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01HL067724, R01HL114858, R01HL072166, R01HL079669, R01HL067724, R01HL085629, R01HL067724, R01HL102738, R01HL067724, R01HL085629, R01HL085629, R01HL102738, R01HL072166, R01HL060590, R01HL060590, R01HL079669, R01HL067724, R01HL072166, R01HL060590, R01HL067724, R01HL067724, R01HL085629, R01HL079669, R01HL060590, R01HL060590, R01HL112330, R01HL060590, R01HL079669, R01HL060590, R01HL114858, R01HL102738, R01HL060590, R01HL112330, R01HL072166, R01HL079669, R01HL079669, R01HL096625, R01HL067724, R01HL085629, R01HL079669, R01HL060590, R01HL060590, R01HL112330, R01HL072166, R01HL060590, R01HL112330, R01HL067724, R01HL060590, R01HL079669, R01HL085629, R01HL067724, R01HL067724, R01HL114858, R01HL079669, R01HL102738, R01HL072166, R01HL079669, R01HL060590, R01HL096625, R01HL112330, R01HL114858, R01HL060590, R01HL106019, R01HL079669, R01HL085629, R01HL072166, R01HL072166, R01HL060590, R01HL112330, R01HL102738, R01HL112330, R01HL085629, R01HL072166, R01HL072166, R01HL072166, R01HL079669, R01HL085629, R01HL072166, R01HL102738, R01HL096625, R01HL114858, R01HL106019, R01HL072166, R01HL067724, R01HL085629, R01HL114858, R01HL072166, R01HL072166, R01HL067724, R01HL085629, R01HL114858, R01HL112330, R01HL067724, R01HL067724, R01HL067724, R01HL114858, R01HL112330, R01HL085629, R01HL096625, R01HL060590, R01HL067724, R01HL112330, R01HL085629, R01HL106019, R01HL106019, R01HL067724, R01HL079669] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI042999, R01AI080703, R01AI089716, R01AI042999, R01AI079065, P01AI056097, R01AI064705, R01AI064705, R01AI064705, R01AI080703, R01AI064705, R01AI079065, R01AI042999, R01AI080703, R01AI042999, P01AI056097, P01AI056097, R01AI081884, R01AI081884, R01AI079065, R01AI079065, R01AI079065, R01AI064705, R01AI080703, P01AI056097, R01AI064705, R01AI064705, R01AI089716, R01AI042999, P01AI056097, R01AI057831, R01AI080703, R01AI080703, R01AI042999, R01AI081884, P01AI056097, R01AI042999, R01AI057831, R01AI057831, R01AI081884, R01AI081884, R01AI042999, R01AI057831, R01AI064705, R01AI042999, R01AI057831, R01AI042999, R01AI064705, R01AI064705, R01AI042999, R01AI057831, R01AI079065, R01AI042999, R01AI042999, P01AI056097, P01AI056097, R01AI042999, R01AI057831, R01AI042999, R01AI042999, R01AI057831, R01AI042999, R01AI057831, R01AI042999, R01AI089716, R01AI042999, R01AI089716, R01AI042999, R01AI089716, R01AI042999] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Dental & Craniofacial Research (NIDCR) [R01DE010742, R01DE010742, R01DE010742] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Dental & Craniofacial Research (NIDCR) [R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742, R01DE010742] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R01DK061498, R01DK094652, R01DK073336, R01DK044234, R01DK079879, R37DK050107, R01DK079879, R01DK082437, R01DK044234, R01DK050610, R01DK050610, R01DK044234, R01DK094652, R01DK050610, R01DK052825, R01DK044234, R01DK073336, R01DK074778, R01DK052825, R01DK082437, R01DK090115, R01DK079879, R01DK050610, R01DK061498, R01DK100644, R01DK052825, R01DK061498, R01DK100644, R01DK061498, R01DK079879, R01DK100644, R01DK044234, R01DK061498, R01DK044234, K01DK087776, R01DK044234, R01DK100644, R01DK050610, R01DK079879, K01DK087776, R01DK074778, R01DK094652, R01DK050610, R01DK074778, R01DK050610, R01DK044234, R01DK052825, R01DK061498, R01DK061498, R01DK094652, R01DK044234, R37DK050107, R01DK061498, R01DK079879, R37DK050107, R01DK044234, R01DK044234, R01DK073336, R01DK052825, R37DK050107, R01DK090115, R01DK050610, R01DK050610, R37DK050107, R01DK044234, R01DK044234, R01DK074778, R01DK094652, R01DK079879, R01DK082437, R01DK061498, R01DK073336, R01DK050610, R01DK050610, R01DK100644, R37DK050107, R01DK052825, R01DK094652, R37DK050107, R01DK079879, R01DK052825, R01DK044234, R01DK061498, R01DK044234, R01DK074778, R01DK074778, R01DK073336, R01DK061498, R01DK090115, R01DK044234, R01DK052825, R01DK044234, R01DK061498, R01DK073336, R01DK044234, K01DK087776, R01DK044234, R01DK074778, R01DK073336, R01DK050610, R37DK050107, R01DK061498, R01DK044234, R01DK052825, R01DK082437, R01DK052825, R01DK050610, R01DK044234, R01DK061498, R01DK052825, R01DK074778, R37DK050107, R01DK073336, R01DK052825, R01DK044234, R01DK044234, R01DK079879, R01DK074778, K01DK087776, R01DK052825, R01DK090115, R01DK050610, R01DK082437, K01DK087776, R01DK082437, R01DK050610, R01DK052825, R01DK044234, R01DK061498, R01DK061498, R01DK052825, R01DK050610, R01DK074778, R01DK044234, R01DK050610, R01DK050610, R37DK050107, R01DK094652, R01DK044234, R01DK050610, R01DK050610, R01DK079879, R01DK044234, R01DK050610] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [R01GM079431, R01GM099040, R01GM062509, R01GM089919, R01GM089919, R01GM053396, R01GM079431, R01GM099040, R01GM062509, R01GM099040, R01GM053396, R01GM099040, R01GM079431, R01GM053396, R01GM097355, R01GM082830, R01GM062509, R01GM053396, R01GM089919, R01GM053396, R01GM053396, R01GM053396, R01GM089919, R01GM053396, R01GM079431, R01GM097355, R01GM062509, R01GM053396, R01GM097355, R01GM053396, R01GM099040, R01GM053396, R01GM053396, R01GM089919, R01GM079431, R01GM079431, R01GM062509, R01GM062509, R01GM079431, R01GM082830, R01GM079431, R01GM062509, R01GM079431, R01GM062509, R01GM053396, R01GM053396, R01GM053396, R01GM082830, R01GM053396, R01GM062509, R01GM099040, R01GM053396, R01GM062509, R01GM082830, R01GM053396, R01GM079431, R01GM062509, R01GM099040, R01GM099040, R01GM079431, R01GM079431, R01GM089919, R01GM062509, R01GM053396, R01GM053396, R01GM097355, R01GM053396, R01GM053396, R01GM053396, R01GM053396, R01GM053396, R01GM062509, R01GM053396, R01GM097355, R01GM062509, R01GM079431, R01GM079431, R01GM053396, R01GM082830] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF MENTAL HEALTHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [R01MH073490, R01MH073490, R01MH073490, R01MH073490, R01MH073490, R01MH073490, R01MH073490, R01MH073490, R01MH073490, R01MH073490, R01MH073490] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS064090, R01NS046451, R01NS080108, R01NS043466, R01NS064090, R01NS050396, R01NS043466, R01NS043466, R01NS046489, R01NS043466, R01NS043466, R01NS046489, R01NS043466, R01NS043466, R01NS043466, R01NS080108, R01NS064090, R01NS046489, R01NS050396, R01NS080108, R01NS046451, R01NS043466, R01NS046451, R01NS080108, R01NS046451, R01NS046489, R01NS050396, R01NS050396, R01NS080108, R01NS064090, R01NS046451, R01NS064090, R01NS046451, R01NS050396] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01AG033283, P30AG028740, R01AG023039, P30AG028740, P30AG028740, P30AG028740, R01AG031867, P30AG028740, P30AG028740, P30AG028740, R01AG023039, P30AG028740, P30AG028740, P30AG028740, R01AG023039, P30AG028740, R01AG033283, R01AG023039, K02AG042095, R01AG023039, P30AG028740, R01AG011833, P30AG028740, P30AG028740, P30AG028740, P30AG028740, R01AG023039, P30AG028740, P30AG028740, P30AG028740, P30AG028740, P30AG028740, P30AG028740, R01AG011833, P30AG028740, R01AG039628, P30AG028740, P30AG028740, R01AG023039, P30AG028740, P30AG028740, R01AG023039, R01AG031867, R01AG031867, R01AG039628, R01AG023039, R01AG023039, P30AG028740, R01AG031867, P30AG028740, R01AG023039, R01AG039628, P30AG028740, R21AG039799, P30AG028740, R01AG031867, R01AG011833, P30AG028740, R01AG031867, R01AG033283, P30AG028740, P30AG028740, P30AG028740, P30AG028740, R01AG023039, R01AG023039, R01AG011833, R01AG023039, R01AG031867, P30AG028740, R01AG039628, K02AG042095, P30AG028740, K02AG042095, P30AG028740, P30AG028740, P30AG028740, P30AG028740, P30AG028740, R01AG011833, P30AG028740, P30AG028740, P30AG028740, P30AG028740, P30AG028740, P30AG028740, P30AG028740, R01AG033283, R01AG033283, R01AG011833, R01AG033283, P30AG028740, P30AG028740, R01AG011833, R01AG039628, K02AG042095, P30AG028740, P30AG028740, R21AG039799, P30AG028740, P30AG028740, R01AG011833, R01AG031867, P30AG028740, P30AG028740, R01AG031867, P30AG028740, R01AG011833, R01AG011833, R01AG031867, P30AG028740, P30AG028740, P30AG028740, R01AG031867, K02AG042095, R01AG023039, R01AG011833, P30AG028740, P30AG028740, R01AG031867, P30AG028740, R01AG031867, R01AG011833, R01AG011833, P30AG028740, P30AG028740, P30AG028740, R01AG011833, P30AG028740, P30AG028740, R01AG011833, P30AG028740, P30AG028740, R01AG031867, R01AG011833, P30AG028740, R01AG023039, R01AG023039, P30AG028740, P30AG028740, R01AG011833, P30AG028740] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISMUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) [R01AA020518, R01AA019730, R01AA020518, R01AA020518, R37AA020518, R01AA020518, R01AA019730, R01AA020518, R01AA020518, R01AA020518, R01AA019730, R01AA019730, R01AA019730, R01AA019730] Funding Source: NIH RePORTER; National Institute on Minority Health and Health DisparitiesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Minority Health & Health Disparities (NIMHD) [G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595, G12MD007595] Funding Source: NIH RePORTER; Veterans AffairsUS Department of Veterans Affairs [I01BX001318, I01BX001318, I01BX001318, I01BX001969, I01BX001318, I01BX001969, I01BX001969, I01BX001318, I01BX001969] Funding Source: NIH RePORTER; Grants-in-Aid for Scientific ResearchMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [26111516, 23570222, 23658069, 23580099, 19380045, 23570241, 24570076, 24680038, 23617020, 18050044, 22590274, 23689032, 15K10908, 23790471] Funding Source: KAKEN; ICREAICREA Funding Source: Custom
机构署名:
本校为其他机构
院系归属:
生命科学学院
摘要:
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.

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