[Jiang, Xingpeng; He, Tingting; Yuan, Jie] Cent China Normal Univ, Sch Comp, Wuhan, Peoples R China.
[Guo, Xiyue; Wang, Yan] Cent China Normal Univ, Natl Engn Res Ctr E Learning, Wuhan, Peoples R China.
通讯机构：
[Yuan, Jie] C
Cent China Normal Univ, Sch Comp, Wuhan, Peoples R China.
语种：
英文
关键词：
PPI network;Phenotype ontology;protein complexes;resolution-limit-free clustering algorithm
期刊：
PROCEEDINGS 2015 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE
ISSN：
2156-1125
年：
2015
页码：
1177-1183
会议名称：
IEEE International Conference on Bioinformatics and Biomedicine - Medical Informatics and Decision Making
会议论文集名称：
IEEE International Conference on Bioinformatics and Biomedicine-BIBM
会议时间：
NOV 09-12, 2015
会议地点：
Washington, DC
会议主办单位：
[Yuan, Jie;Jiang, Xingpeng;He, Tingting] Cent China Normal Univ, Sch Comp, Wuhan, Peoples R China.^[Wang, Yan;Guo, Xiyue] Cent China Normal Univ, Natl Engn Res Ctr E Learning, Wuhan, Peoples R China.
会议赞助商：
IEEE, IEEE Comp Soc, Natl Sci Fdn
主编：
Huan, J Miyano, S Shehu, A Hu, X Ma, B Rajasekaran, S Gombar, VK Schapranow, IM Yoo, IH Zhou, JY Chen, B Pai, V Pierce, B
Predicting disease genes in PPI network has attracted a lot of attention over the years. Based on the assumption that the phenotypes of the genes in the same complex where candidate gene located in are more similar to disease, the candidate gene is more possible to be disease gene, we propose a new disease gene identification method based on protein complex phenotype similarity. First, our method mines protein complexes in PPI network by resolution-limit-free clustering algorithm and maps the candidate genes to complexes. Second, we define phen...
