期刊论文

Chen, Jia-Rong;Xiao, Wen-Jing

英文

Organic Letters

1523-7060

2019

21

17

6924-6929

10.1021/acs.orglett.9b02535

NNSFCNational Natural Science Foundation of China (NSFC) [21622201, 91856119, 21820102003, 21772053]; Science and Technology Department of Hubei Province [2017AHB047]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [CCNU19TS051]; Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]

本校为第一且通讯机构

A light-driven, metal-free, and iminyl radical-mediated ring-opening C-C bond cleavage/addition cascade of O-4-methoxybenzyl oxime ethers and alkenes is described for the first time. The reaction shows a broad substrate scope and high functional group compatibility with both components, giving the corresponding valuable oxo nitriles in generally good yields. Key to the success of this protocol is the generation of cyclic iminyl radicals from the O-4-methoxybenzyl oxime ethers via a photocatalytic hydrogen atom transfer (HAT) process. The proposed ...