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Design, Synthesis, and 3D-QSAR Analysis of Novel 1,3,4-Oxadiazol-2(3H)-ones as Protoporphyrinogen Oxidase Inhibitors

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成果类型:
期刊论文
作者:
Li-Li Jiang;Ying Tan;Xiao-Lei Zhu;Zhi-Fang Wang;Yang Zuo;...
通讯作者:
Zhen Xi
作者机构:
[Guang-Fu Yang; Yang Zuo; Xiao-Lei Zhu; Li-Li Jiang; Zhi-Fang Wang; Qiong Chen; Ying Tan] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, Wuhan 430079, Peoples R China.
[Zhen Xi; Zhi-Fang Wang; Ying Tan] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China.
通讯机构:
[Zhen Xi] N
Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China.
语种:
英文
关键词:
Protoporphyrinogen oxidase;1,3,4-oxadiazol-2(3H)-ones;benzothiazole;herbicide
期刊:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN:
0021-8561
年:
2010
卷:
58
期:
5
页码:
2643-2651
机构署名:
本校为第一机构
院系归属:
化学学院
摘要:
Protoporphyrlnogen oxidase (PPO, EC 1.3.3.4) has been Identified as one of the most significant action targets for a large chemically diverse family of herbicides that exhibit some Interesting characteristics, such as low use rate, low toxicity to mammals, and low environmental Impact. As a continuation of research work on the development of new PPO Inhibitors, some benzothlazole analogues of oxadlargyl, an Important PPO-lnhlbltlng commercial herbicide, were designed and synthesized by ring-closing of the substltuents at the C-4 and C-5 positio...

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