Transdermal drug delivery system have an incomparable superiority to traditional medication systems, but its application is limited owing to low skin permeability. For the present situation, the characters of dose-pulse based on the principle of transdermal drug delivery is analyzed. Then several high accurate pulse waves and their combination are regenerated based on the theory of eleetroporation, sonophoresis and ontophoresis. Finally, experimental results show that system effectively promotes drugs permeability through skin by...