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Glycopeptide ligation via direct aminolysis of selenoester

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成果类型:
期刊论文、会议论文
作者:
Du, Jing-Jing;Xin, Ling-Ming;Lei, Ze;Zou, Shi-Yao;Xu, Wen-Bo;...
通讯作者:
Gao, Xiao-Fei;Guo, Jun
作者机构:
[Lei, Ze; Zhang, Lian; Xin, Ling-Ming; Xu, Wen-Bo; Du, Jing-Jing; Gao, Xiao-Fei; Guo, J; Zou, Shi-Yao; Guo, Jun; Wang, Chang-Wei] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan 430079, Hubei, Peoples R China.
[Gao, Xiao-Fei] East China Univ Technol, Jiangxi Key Lab Mass Spectrometry & Instrumentat, Nanchang 330013, Jiangxi, Peoples R China.
通讯机构:
[Gao, XF; Guo, J] C
Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan 430079, Hubei, Peoples R China.
语种:
英文
关键词:
Glycolpeptide;Aminolysis;Selenoester;Additive-free;MUC1 mucin
期刊:
中国化学快报:英文版
ISSN:
1001-8417
年:
2018
卷:
29
期:
7
页码:
1127-1130
会议名称:
15th Chinese International Peptide Symposium (CPS)
会议时间:
JUL 04-06, 2018
会议地点:
Tsinghua Univ, Shenzhen, PEOPLES R CHINA
会议主办单位:
Tsinghua Univ
出版地:
360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
出版者:
ELSEVIER SCIENCE INC
基金类别:
This work is supported by the National Key Research and Development Program of China (No. 2017YFA0505200 ), the National Natural Science Foundation of China (No. 21772056 ), Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation Open Foundation ( JXMS201701 ), the self-determined research funds of CCNU from the colleges' basic research and operation of MOE (No. CCNU18TS011) and the Program of Introducing Talents of Discipline to Universities of China (111 program, No. B17019).
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
Direct aminolysis of selenoester in aqueous media was investigated as a glycopeptide ligation strategy. This strategy allows the peptide and glycopeptide ligation to proceed smoothly (even with hindered amino acids) without the need of cysteine residue, N-terminal thiol auxiliary or coupling additive, and to afford the corresponding amide products in excellent yields. No epimerization was observed during ligation reations. In this work, the selenoester of unprotected glycopeptide was readily prepared, and the direct aminolysis of glycopeptide selenoester w...

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