Using the anti-de Sitter/conformal field theory (AdS/CFT) correspondence, we study the holographic Schwinger effect in an anisotropic background with the Gauss-Bonnet term. As the background geometry is anisotropic, we consider both cases of the test particle pair and the electric field perpendicular to and parallel to the anisotropic direction. It is shown that the Schwinger effect is enhanced in the perpendicular case when anisotropy rises. In the parallel case, this effect is reversed. Additionally, the potential barrier and the critical electric field in the parallel case are more signific...
