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Detection of Intracellular Selenol-Containing Molecules Using a Fluorescent Probe with Near-Zero Background Signal

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成果类型:
期刊论文
作者:
Sun, Qi;Yang, Shu-Hou;Wu, Lei;Dong, Qing-Jian;Yang, Wen-Chao*;...
通讯作者:
Yang, Wen-Chao;Yang, Guang-Fu
作者机构:
[Yang, Guang-Fu; Yang, Wen-Chao; Sun, Qi; Yang, Shu-Hou; Wu, Lei; Yang, WC; Yang, GF] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
[Dong, Qing-Jian] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Nucl Med, Tongji Med Coll, Wuhan 430030, Peoples R China.
通讯机构:
[Yang, WC; Yang, GF] C
Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
语种:
英文
期刊:
Analytical Chemistry
ISSN:
0003-2700
年:
2016
卷:
88
期:
11
页码:
6084-6091
基金类别:
We are grateful for the financial support from the National Natural Science Foundation of China (Grant Nos. 21332004 and 21372094).
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
Selenocysteine (Sec), encoded as the 21st amino acid, is the predominant chemical form of selenium that is closely related to various human diseases. Thus, it is of high importance to identify novel probes for sensitive and selective recognition of Sec and Sec-containing proteins. Although a few probes have been reported to detect artificially introduced selenols in cells or tissues, none of them has been shown to be sensitive enough to detect endogenous selenols. We report the characterization and application of a new fluorogenic molecular pro...

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