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Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway

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成果类型:
期刊论文
作者:
Xie, Xiaoman;Deng, Ting;Duan, Jiufei;Xie, Jing;Yuan, Junlin;...
通讯作者:
Chen, Mingqing
作者机构:
[Xie, Jing; Yuan, Junlin; Chen, Mingqing; Duan, Jiufei; Deng, Ting; Xie, Xiaoman] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
[Chen, Mingqing] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.
通讯机构:
[Chen, Mingqing] C
Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
MAPK signaling pathway;Microplastics;Oxidative stress;Polystyrene microplastics;Reproductive toxicity
期刊:
Ecotoxicology and Environmental Safety
ISSN:
0147-6513
年:
2020
卷:
190
页码:
110133
基金类别:
CRediT authorship contribution statement Xiaoman Xie: Investigation, Validation, Methodology, Data curation, Writing - original draft. Ting Deng: Conceptualization, Methodology, Investigation. Jiufei Duan: Methodology, Software. Jing Xie: Investigation. Junlin Yuan: Project administration. Mingqing Chen: Conceptualization, Methodology, Writing - review & editing, Project administration, acquisition, Supervision.
机构署名:
本校为第一且通讯机构
院系归属:
生命科学学院
摘要:
Microplastics (MP) are receiving increased attention as a harmful environmental pollutant, however information on the reproduction toxicity of MP in terrestrial animals, especially mammals, is limited. In this experiment, we investigated the impact of polystyrene microplastics (micro-PS) on the reproductive system of male mice. Healthy Balb/c mice were exposed to saline or to different doses of micro-PS for 6 weeks. The results showed that micro-PS exposure resulted in a significant decrease in the number and motility of sperm, and a significan...

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