版权说明 操作指南
首页 > 成果 > 详情

Cyanine-based fluorescent probe for highly selective detection of glutathione in cell cultures and live mouse tissues

认领
导出
Link by 万方学术期刊
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Yin, Jun;Kwon, Younghee;Kim, Dabin;Lee, Dayoung;Kim, Gyoungmi;...
通讯作者:
Ryu, Ji-Hwan
作者机构:
[Kim, Dabin; Kim, Gyoungmi; Yoon, Juyoung; Hu, Ying; Yin, Jun; Lee, Dayoung] Ewha Womans Univ, Dept Chem & Nano Sci, Global Top Res Program 5, Seoul 120750, South Korea.
[Yin, Jun] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
[Kwon, Younghee; Ryu, Ji-Hwan] Yonsei Univ, Coll Med, Res Ctr Human Nat Def Syst, Seoul 120752, South Korea.
[Kwon, Younghee; Ryu, Ji-Hwan] Yonsei Univ, Coll Med, BK Plus Project Med Sci 21, Seoul 120752, South Korea.
通讯机构:
[Ryu, Ji-Hwan] Y
Yonsei Univ, Coll Med, Res Ctr Human Nat Def Syst, Seoul 120752, South Korea.
语种:
英文
关键词:
N-methylmaleimide (NMM);pathologies;Glutathione (GSH)
期刊:
Journal of the American Chemical Society
ISSN:
0002-7863
年:
2014
卷:
136
期:
14
页码:
5351-5358
基金类别:
National Creative Research Initiative programs of the National Research Foundation of Korea (NRF); Korean government (Ministry of Science, ICT and Future Planning, MSIP) [2012R1A3A2048814]; Basic Science Research Program through the NRF; Ministry of Education [2013R1A1A200]; Bio & Medical Technology Development Program of the NRF; MSIP [NRF-2013M3A9D5072551]
机构署名:
本校为其他机构
院系归属:
化学学院
摘要:
Glutathione (GSH) plays a crucial role in human pathologies. Near-infrared fluorescence-based sensors capable of detecting intracellular GSH in vivo would be useful tools to understand the mechanisms of diseases. In this work, two cyanine-based fluorescent probes, 1 and 2, containing sulfonamide groups were prepared. Evaluation of the fluorescence changes displayed by probe 1, which contains a 2,4-dinitrobenzenesulfonamide group, shows that it is cell-membrane-permeable and can selectively detect thiols such as GSH, cysteine (Cys), and homocyst...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com