期刊论文

Zhang, Xinan

英文

PLOS ONE

1932-6203

2012

7

4

e35700-

10.1371/journal.pone.0035700

National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [DP2 116520]; Oak Ridge Associated Universities; NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR000005, UL1TR000005, UL1TR000005, UL1TR000005, UL1TR000005, UL1TR000005] Funding Source: NIH RePORTER; NATIONAL CENTER FOR RESEARCH RESOURCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Research Resources (NCRR) [UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153] Funding Source: NIH RePORTER

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Embryonic stem cells are conventionally differentiated by modulating specific growth factors in the cell culture media. Recently the effect of cellular mechanical microenvironment in inducing phenotype specific differentiation has attracted considerable attention. We have shown the possibility of inducing endoderm differentiation by culturing the stem cells on fibrin substrates of specific stiffness [1]. Here, we analyze the regulatory network involved in such mechanically induced endoderm differentiation under two different experimental configurations of 2-dimensional and 3-dimensional cultur...