期刊论文、会议论文

Wu, Yan-dong;Wu, An-xin

中文

Organic Letters

1523-7060

2016

18

10

2507-2510

中国化学会第30届学术年会

中国化学会第30届学术年会论文集

2016-07-01

大连

中国化学会

10.1021/acs.orglett.6b01162

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21272085, 21472056]; Central China Normal University [2015YBYB087]

本校为第一且通讯机构

一个从未被报道过的苯胺和甲基酮的直接双C-H键官能团化己经被发展起来。这是第一例碘促进的高的化学选择性和位置选择性实现苯胺和甲基酮的C-H/C-H氧化交叉偶联,并以一个中等至好的收率实现了苯胺的C4位双羰基化。此外,副产物HI在该反应中也起到一个催化剂的作用。这种方法的突出特点是前所未有地实现了苯胺的C-H官能化而不是N-H官能化(Scheme 1)。[1,2,3]

An unprecedented direct dual C–H bond functionalization of unprotected anilines and methyl ketones has been demonstrated. It is the first example of iodine-promoted highly chemo- and site-selective oxidative C–H/C–H cross-coupling of anilines and methyl ketones to furnish the C4-dicarbonylation of anilines in moderate to good yields. Moreover, coproduct HI acted as a catalyst in the reaction. The salient feature of this approach is unprecedented C–H functionalization rath...