National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31371275, 30971635]; CCNU from the colleges' basic research and operation of MOEMinistry of Education, Singapore [CCNU14Z01003]
机构署名：
本校为第一且通讯机构
院系归属：
生命科学学院
计算机学院
摘要：
Objectives Genome-wide association studies (GWASs) have revealed many SNPs and genes associated with osteoporosis. However, influence of these SNPs and genes on the predisposition to osteoporosis is not fully understood. We aimed to identify osteoporosis GWASs-associated SNPs potentially influencing the binding affinity of transcription factors and miRNAs, and reveal enrichment signaling pathway and “hub” genes of osteoporosis GWAS-associated genes. Methods We conducted multiple computational analyses to explore function and mechanisms of ost...
