作者：
Li, Sijia;Pan, Wei;Yip, Paul Siu Fai;Wang, Jing;Zhou, Wenwei;...
期刊：
Computers in Human Behavior,2024年152:108080 ISSN：0747-5632
通讯作者：
Pan, W;Yip, PSF
作者机构：
[Pan, Wei; Zhou, Wenwei; Wang, Jing] Univ Hong Kong, Fac Social Sci, Dept Social Work & Social Adm, Hong Kong, Peoples R China.;[Pan, Wei; Zhou, Wenwei; Wang, Jing] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan, Peoples R China.;[Pan, Wei; Zhou, Wenwei; Wang, Jing] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Yip, Paul Siu Fai] Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan, Peoples R China.;[Zhu, Tingshao] Univ Hong Kong, Hong Kong Jockey Club Ctr Suicide Res & Prevent, Hong Kong, Peoples R China.
通讯机构：
[Pan, W ] C;[Yip, PSF ] U;Cent China Normal Univ, Sch Psychol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;Univ Hong Kong, Fac Social Sci, Dept Social Work & Social Adm, Room 511,Jockey Club Tower,Centennial Campus, Pokfulam, Hong Kong, Peoples R China.
摘要：
Depression has been identified as a risk factor for suicide, yet limited evidence has elucidated the underlying pathways linking depression to subsequent suicide risk. Therefore, we aimed to examine the psychological mechanisms that connect depression to suicide risk via linguistic characteristics on Weibo. We sampled 487,251 posts from 3196 users who belong to the depression super-topic community (DSTC) on Sina Weibo as the depression group, and 357,939 posts from 5167 active users as the control group. We employed the double machine learning method (DML) to estimate the impact of depression on suicide risk, and interpreted the pathways from depression to suicide risk using SHapley Additive exPlanations (SHAP) values and tree in-terpreters. The results indicated an 18% higher likelihood of suicide risk in the depression group compared to people without depression. The SHAP values further revealed that Exclusive (M = 0.029) was the most critical linguistic feature. Meanwhile, the three-depth tree interpreter illustrated that the high suicide risk subgroup of the depression group (N = 1196, CATE = 0.32 +/- 0.04, 95%CI [0.20, 0.43]) was predicted by higher usage of Exclusive (>0.59) and Health (>-0.10). DML revealed pathways linking depression to suicide risk. The visualized tree interpreter showed cognitive complexity and physical distress might be positively associated with suicide risk in depressed populations. These findings have invigorated further investigation to elucidate the relationship between depression and suicide risk. Understanding the underlying mechanisms serves as a basis for future research on suicide prevention and treatment for individuals with depression.
期刊：
CHEMISTRY-AN ASIAN JOURNAL,2024年19(2):e202300860- ISSN：1861-4728
通讯作者：
Liu, SH;Hartl, F
作者机构：
[Yang, Xiao Fei; Liu, Sheng Hua; Liu, SH; Zhang, Ming-Xing] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Zhang, Ming-Xing] Hubei Univ Educ, Coll Chem & Life Sci, Hubei Key Lab Purificat & Applicat Plant Anticanc, Wuhan 430205, Peoples R China.;[Hartl, Frantisek; Hartl, F] Univ Reading, Dept Chem, Reading RG6 6DX, England.
通讯机构：
[Liu, SH ] C;[Hartl, F ] U;Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;Univ Reading, Dept Chem, Reading RG6 6DX, England.
摘要：
The reviewed literature documents that certain metallaaromatics with unconventional photophysical properties, redox and electronic transport properties and magnetism, have potential to be widely used in diverse practical applications, with selected examples of amino acid identification, photothermal effects, functional materials, photodynamic therapy (PDT) in biomedicine, single‐molecule junction conductors, and electron‐transport layer materials (ETLs) in solar cells. Abstract In recent years, the field of organometallic chemistry has made a great progress and diverse types of metallaaromatics have successively been reported. In those studies, incorporation of ligated osmium centers into metallaaromatic systems played a prominent role. The reviewed literature documents that certain metallaaromatics with unconventional photophysical properties, redox and electronic transport properties and magnetism, have potential to be widely used in diverse practical applications, with selected examples of amino acid and fluoride anion identification, photothermal effects, functional materials, photodynamic therapy (PDT) in biomedicine, single‐molecule junction conductors, and electron‐transport layer materials (ETLs) in solar cells.
摘要：
Abstract Considerable research has been dedicated to studying teachers' digital competence, yet limited insights have been gained regarding its impact on online teacher autonomy support. Based on the Technological Pedagogical Content Knowledge (TPACK) framework, this study utilized a multiple regression analysis model to explore how teachers' digital competence affects online teacher autonomy support. Drawing on data from 652 Chinese primary school teachers, the study revealed that teachers' digital competence positively influenced online teacher autonomy support via teachers' cognitive empathy. Teachers' emotional empathy strengthened the direct effect of cognitive empathy on online teacher autonomy support, and its indirect effect on teachers' digital competence on online teacher autonomy support. The findings inform TPACK framework development and practical considerations in online teaching, deepening understanding of the impact of digital competence on online teacher autonomy support.Practitioner notesWhat is already known about this topic Previous research has recognized the importance of teachers' digital competence in supporting learners' autonomy and enhancing their online learning experiences. Existing studies have explored different dimensions of teachers' digital competence, including technological proficiency, pedagogical knowledge and content expertise. Studies have also examined the role of empathy in online teaching and learning, emphasizing its importance in fostering positive teacher–student relationships and promoting student engagement and motivation. What this paper adds This study introduces digital competence as a novel and comprehensive assessment of technology integration in teaching, bridging an existing gap in the literature. This study recognizes the importance of socio‐emotional skills in online teaching by including teachers' empathic traits within the expanded TPACK framework. Teachers' cognitive empathy acts as a mediator and emotional empathy functions as a moderator in the relationship between digital competence and online teacher autonomy support, offering new insights into the underlying mechanisms. Implications for practice and/or policy Teacher educators should find ways to support teachers' digital competence in facilitating learners' autonomy in online learning environments effectively. Teacher educators should incorporate teacher empathy development into teachers' professional development programmes for online teaching, offering tailored interventions to differentiate and enhance both cognitive and emotional empathy.
关键词：
Compressible Navier-Stokes-Allen-Cahn system;Strong/classical solutions;Density-dependent viscosity;Large initial data
摘要：
This paper is concerned with a one-dimensional isentropic compressible Navier-Stokes-Allen-Cahn system with density-dependent viscosity, which models the motion of a mixture of two viscous compressible fluids. The case when the pressure $ p(\rho) = \rho^\gamma $, the viscosity $ \nu(\rho, \chi) = \rho^\alpha $, the interface thickness $ \delta(\rho) = \rho^\beta $ and the relaxation time function $ a(\rho, \chi, \chi_y) = \rho^\lambda $ is considered, where $ \rho $ and $ \chi $ are the density and the phase variable, respectively, and $ \gamma, \alpha, \beta, \lambda\in\mathbb{R} $ are parameters. Under some suitable assumptions on the parameters $ \gamma , \alpha, \beta, \lambda $ and the initial data, we prove the global existence and large-time behavior of nonvacuum strong and classical solutions to its Cauchy problem with large initial data. This appears to be the first global existence result on the Cauchy problem of the compressible Navier-Stokes-Allen-Cahn system with density-dependent viscosity and large data.
作者机构：
[Ye Lu; Guang-You Qin] Institute of Particle Physics and Key Laboratory of Quark and Lepton Physics (MOE), Central China Normal University,Wuhan 430079, China;[Chang Chen] Department of Physics, Peking University, Beijing 100871, China;[Han-Qing Zheng] College of Physics, Sichuan University, Chengdu 610065, China
摘要：
The attractive interaction between and has to be strong enough if X(6900) is of the molecule type. We argue that since decays predominantly into a pair, the interactions between and may be significantly enhanced owing to the three point loop diagram. The enhancement originates from the anomalous threshold located at GeV , whose effect propagates into the s-channel partial wave amplitude in the vicinity of GeV. This effect may be helpful in the formation of the peak.
摘要：
Cancer cells need a greater supply of glucose mainly due to their aerobic glycolysis, known as the Warburg effect. Glucose transport by glucose transporter 1 (GLUT1) is the rate-limiting step for glucose uptake, making it a potential cancer therapeutic target. However, GLUT1 is widely expressed and performs crucial functions in a variety of cells, and its indiscriminate inhibition will cause serious side effects. In this study, we designed and synthesized a photocaged GLUT1 inhibitor WZB117-PPG to suppress the growth of cancer cells in a spatiotemporally controllable manner. WZB117-PPG exhibited remarkable photolysis efficiency and substantial cytotoxicity toward cancer cells under visible light illumination with minimal side effects, ensuring its safety as a potential cancer therapy. Furthermore, our quantitative proteomics data delineated a comprehensive portrait of responses in cancer cells under glucose deprivation, underlining the mechanism of cell death via necrosis rather than apoptosis. We reason that our study provides a potentially reliable cancer treatment strategy and can be used as a spatiotemporally controllable trigger for studying nutrient deprivation-related stress responses.
期刊：
INTERNATIONAL JOURNAL OF CLIMATE CHANGE STRATEGIES AND MANAGEMENT,2024年16(1):1-18 ISSN：1756-8692
通讯作者：
Tong, QM
作者机构：
[Liu, Xuan; Tong, Qingmeng; Ran, Shan; Tong, QM] Cent China Normal Univ, Sch Econ & Business Adm, Wuhan, Peoples R China.;[Zhang, Lu; Zhang, Junbiao] Huazhong Agr Univ, Coll Econ & Management, Wuhan, Peoples R China.
通讯机构：
[Tong, QM ] C;Cent China Normal Univ, Sch Econ & Business Adm, Wuhan, Peoples R China.
关键词：
Agricultural internet information (AII);Climate resilience;China;Rice production;Recursive binary probit model
摘要：
Purpose
The main purpose of this study is to examine the impact of agricultural internet information (AII) acquisition on climate-resilient variety adoption among rice farmers in the Jianghan Plain region of China. Additionally, it explores the influencing channels involved in this process.
Design/methodology/approach
Based on survey data for 877 rice farmers from 10 counties in the Jianghan Plain, China, this paper used an econometric approach to estimate the impact of AII acquisition on farmers’ adoption of climate-resilient varieties. A recursive bivariate Probit model was used to address endogeneity issues and obtain accurate estimates. Furthermore, three main influencing mechanisms were proposed and tested, which are broadening information channels, enhancing social interactions and improving agricultural skills.
Findings
The results show that acquiring AII can overall enhance the likelihood of farmers adopting climate-resilient varieties by 36.8%. The three influencing channels are empirically confirmed. Besides, educational attainment, income and peer effects can facilitate farmers’ acquisition of AII, while climate conditions and age significantly influence the adoption of climate-resilient varieties.
Practical implications
Practical recommendations are put forward to help farmers build climate resilience, including investing in rural internet infrastructures, enhancing farmers’ digital literacy and promoting the dissemination of climate-resilient information through diverse internet platforms.
Originality/value
Strengthening climate resilience is essential for sustaining the livelihoods of farmers and ensuring national food security; however, the role of internet information has received limited attention. To the best of the authors’ knowledge, this study is the first to examine the casual relationship between internet information and climate resilience, which fills the research gap.
摘要：
The HIV-1 transactivator protein Tat interacts with the transactivation response element (TAR) at the three-nucleotide UCU bulge to facilitate the recruitment of transcription elongation factor-b (P-TEFb) and induce the transcription of the integrated proviral genome. Therefore, the Tat-TAR interaction, unique to the virus, is a promising target for developing antiviral therapeutics. Currently, there are no FDA-approved drugs against HIV-1 transcription, suggesting the need to develop novel inhibitors that specifically target HIV-1 transcription. We have identified potential candidates that effectively inhibit viral transcription in myeloid and T cells without apparent toxicity. Among these candidates, two molecules showed inhibition of viral protein expression. A molecular docking and simulation approach was used to determine the binding dynamics of these small molecules on TAR RNA in the presence of the P-TEFb complex, which was further validated by a biotinylated RNA pulldown assay. Furthermore, we examined the effect of these molecules on transcription factors, including the SWI/SNF complex (BAF or PBAF), which plays an important role in chromatin remodeling near the transcription start site and hence regulates virus transcription. The top candidates showed significant viral transcription inhibition in primary cells infected with HIV-1 (98.6). Collectively, our study identified potential transcription inhibitors that can potentially complement existing cART drugs to address the current therapeutic gap in current regimens. Additionally, shifting of the TAR RNA loop towards Cyclin T1 upon molecule binding during molecular simulation studies suggested that targeting the TAR loop and Tat-binding UCU bulge together should be an essential feature of TAR-binding molecules/inhibitors to achieve complete viral transcription inhibition.
作者机构：
Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education, Wuhan, China;School of Psychology, Central China Normal University, Wuhan, China;[Lu Huang] School of Marxism, Wuhan Business University, Wuhan, China;[Youzhi Song; Yuan Tian; Cuiying Fan; Quan Zheng; Zongkui Zhou] Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education, Wuhan, China<&wdkj&>School of Psychology, Central China Normal University, Wuhan, China
通讯机构：
[Zongkui Zhou] K;Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education, Wuhan, China<&wdkj&>School of Psychology, Central China Normal University, Wuhan, China
摘要：
Early research has revealed distinct subgroups of cyberbullying victims. However, due to the limitations of traditional statistical methods, the characterization of features in the subgroups has been relatively limited, making it challenging to gain a relatively comprehensive understanding of different subgroup members. Decision trees and machine learning techniques offer notable advantages in addressing such issues. The primary aim of this study is to develop a high-performing classifier based on self-reported data from 814 middle school students to accurately predict cyberbullying victimization and uncover the most influential factors. On this basis, the study attempts to identify different subgroups of cyberbullying victims and their shared characteristics. The results indicated that the classification tree achieved a prediction accuracy of approximately 80% on the out-of-sample dataset. The results of permutation feature importance highlighted that the most prominent predictors were the victim’s cyberbullying perpetration, followed by traditional relational victimization and depression. Further examination of the visual tree structure revealed subgroups of cyberbullying victims and their shared characteristics. The findings of this study have enriched the characteristics of different subgroups of cyberbullying victims, providing a better elucidation of the pathology of cyberbullying victimization and offering empirical evidence to facilitate the development of more targeted intervention strategies for various subgroups of cyberbullying victims.
摘要：
This paper focuses on the existence of positive solutions for the following weakly coupled Schrödinger system with supercritical growth except at the origin: $ \begin{equation*} \left\{ \begin{array}{ll} -\Delta u_1 = \mu_1|u_{1}|^{p(r) - 2}u_1 + \beta|u_{2}|^{\frac{p(r)}{2}}|u_1|^{\frac{p(r)}{2}-2}u_{1}, & x\in B_1(0), \\ -\Delta u_2 = \mu_2|u_{2}|^{p(r) - 2}u_{2} + \beta|u_{1}|^{\frac{p(r)}{2}}|u_2|^{\frac{p(r)}{2}-2}u_{2}, & x\in B_1(0), \end{array} \right. \end{equation*} $ where $ B_1(0) $ is an unit ball $ {\mathbb{R}^N} $ with $ N\ge 3 $, $ \beta\in\mathbb{R} $ is a coupling constant, $ \mu_1,\mu_2\in {\mathbb R} $ are constants, $ p(r) = 2^* + r^{\alpha} $ with $ 2^* = \frac{2N}{N-2} $. Assuming that $ 0<{\alpha}<\min\{\frac{N}{2},N-2\} $, we apply concentration-compactness idea to show that the problem has a positive solution provided that $ \beta>0 $ if $ N\ge 5 $ and $ \beta\in(0,\beta_0]\cup[\beta_1,+\infty) $ for some positive constants $ \beta_0<\beta_1 $ if $ N = 3,4 $.
摘要：
Visual Dialog aims to answer an appropriate response based on a multi-round dialog history and a given image. Existing methods either focus on semantic interaction, or implicitly capture coarse-grained structural interaction (e.g., pronoun co-references). The fine-grained and explicit structural interaction feature for dialog history is seldom explored, resulting in insufficient feature learning and difficulty in capturing precise context. To address these issues, we propose a structure-aware dual-level graph interactive network (SDGIN) that integrates verb-specific semantic roles and co-reference resolution to explicitly capture context structural features for discriminative and generative tasks in visual dialog. Specifically, we create a novel structural interaction graph that injects syntactic knowledge priors into dialog by introducing semantic role labeling that imply which words are sentence stems. Furthermore, considering the single perspective limitation of previous algorithms, we design a dual-perspective mechanism that learns fine-grained token-level context structure features and coarse-grained utterance-level interactions in parallel. It possess an elegant view to explore precise context interactions, realizing the mutual complementation and enhancement of different granularity features. Experimental results show the superiority of our proposed approach. Compared to other task-specific models, our SDGIN outperforms previous models and achieves a significant improvement on the benchmark dataset VisDial v1.0.
摘要：
Eukaryotic DNA is packaged into chromatin in the nucleus, restricting the binding of transcription factors (TFs) to their target DNA sites. FOXA1 functions as a pioneer TF to bind condensed chromatin and initiate the opening of local chromatin for gene expression. However, the principles of FOXA1 recruitment and how it subsequently unpacks the condensed chromatin remain elusive. Here, we revealed that FOXA1 intrinsically forms submicron-sized condensates through its N- and C-terminal intrinsically disordered regions (IDRs). Notably, both IDRs enable FOXA1 to dissolve the condensed chromatin. In addition, the DNA-binding capacity of FOXA1 contributes to its ability to both form condensates and dissolve condensed chromatin. Further genome-wide investigation showed that IDRs enable FOXA1 to bind and unpack the condensed chromatin to regulate the proliferation and migration of breast cancer cells. This work provides a principle of how pioneer TFs function to initiate competent chromatin states using their IDRs.
作者机构：
[Zhu, Lei; Pan, Hu; Li, Jinglin; Li, Yixin; Wang, Zhouzhou; Zhou, Baowen; Yu, Tianqi] Key Laboratory for Power Machinery and Engineering of Ministry of Education, Research Center for Renewable Synthetic Fuel, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China;[Wang, Zhouzhou; Yu, Ying] Institute of Nanoscience and Nanotechnology, College of Physical Science and Technology, Central China Normal University, Wuhan, 430079, China;[Song, Jun; Chen, Yiqing] Department of Mining and Materials Engineering, McGill University, Montreal, QC H3A0C9, Canada;[Wang, Xinqiang; Sheng, Bowen; Wang, Ping] State Key Laboratory of Artificial Microstructure and Mesoscopic Physics, School of Physics, Nano-Optoelectronics Frontier Center of Ministry of Education (NFC-MOE), Peking University, Beijing, 100871, China;[Yao, Lin] China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai, 201306, China
关键词：
Air-promoted strategy;Bioethanol reforming;Core/shell Cr2O3@GaN nanoarchitecture;High TOF/TON;Photocatalytic H2 production
摘要：
Light-driven hydrogen production from biomass derivatives offers a path towards carbon neutrality. It is often however operated with the limitations of sluggish kinetics and severe coking. Herein, a disruptive air-promoted strategy is explored for efficient and durable light-driven hydrogen production from ethanol over a core/shell Cr(2) O(3) @GaN nanoarchitecture. The correlative computational and experimental investigations show ethanol is energetically favorable to be adsorbed on the Cr(2) O(3) @GaN interface, followed by dehydrogenation toward acetaldehyde and protons by photoexcited holes. The released protons are then consumed for H(2) evolution by photogenerated electrons. Afterward, O(2) can be evolved into active oxygen species and promote the deprotonation and C-C cleavage of the key C(2) intermediate, thus significantly lowering the reaction energy barrier of hydrogen evolution and removing the carbon residual with inhibited overoxidation. Consequently, hydrogen is produced at a high rate of 76.9 mole H(2) per gram Cr(2) O(3) @GaN per hour by only feeding ethanol, air, and light, leading to the achievement of a turnover number of 266,943,000 mole H(2) per mole Cr(2) O(3) over a long-term operation of 180 hours. Notably, an unprecedented light-to-hydrogen efficiency of 17.6 % is achieved under concentrated light illumination. The simultaneous generation of aldehyde from ethanol dehydrogenation enables the process more economically promising.
