通讯机构:
[Zhang, ZH; Lei, HH ] C;Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.;Wuhan Inst Photochem & Technol, Wuhan 430083, Hubei, Peoples R China.
摘要:
Regioselective C-H amination of simple arenes is highly desirable, but accessing meta-sites of ubiquitous arenes has proven challenging due to the lack of both electronic and spatial preference. This study demonstrates the successful use of various privileged nitrogen-containing functionalities found in pharmaceutical compounds to direct meta-C-H amination of arenes, overcoming the long-standing requirement for a redundant directing group. The remarkable advancements in functional group accommodation for precise regiochemical control were achieved through the discovery of an unprecedented organo-initiator and the strategic utilization of non-covalent interactions. This protocol has been successfully applied in the concise synthesis and late-stage derivatization of drug molecules, which would have been otherwise challenging to achieve.
作者机构:
[Wang, Mengke; Chen, Zengzhao; Shi, Yawen; Long, Taotao] Cent China Normal Univ, Fac Artificial Intelligence Educ, Nanhu Campus,382 Xiongchu Ave, Wuhan, Hubei, Peoples R China.;[Wu, Xuemei] Zhejiang Normal Univ, Dept Educ Technol, 688 Yingbin Dadao, Jinhua, Zhejiang, Peoples R China.;[Xu, Ling] Xiamen Expt Middle Sch, 6666 Binhai West Ave, Xiamen City, Fujian Province, Peoples R China.
关键词:
Classroom interaction;Instructional proxemics;Teacher professional development;Exemplary lessons;Multimodal learning analytics
摘要:
The application of information technology in the classroom is not a new thing. There have been many studies on the impact of information technology on teachers' teaching and students' learning. However, few studies focus on how information technology affects classroom interaction and instructional proxemics. In this study, 43 exemplary lessons with the application of information technology in teaching were analyzed to investigate the interaction types and instructional proxemics, as well as the relationship between them. The results show that the interaction between students and tools or environment is the most frequent among student-centered interactions. Instructional proxemics shows that teachers spend nearly one-third of their classroom time in the student area. There are significant differences in the spatial location of teachers for different types of classroom interaction. Finally, teachers interacted most with students who were at a social distance, followed by the public, personal, and intimate distance. This study not only makes up for the gap in the research of classroom interaction and instructional proxemics under the environment supported by information technology but also provides a reference for novice teachers to use instructional proxemics to carry out interactive teaching.
期刊:
Global Change Biology,2024年30(1):e17027 ISSN:1354-1013
通讯作者:
Fang, LC
作者机构:
[Fang, Linchuan; Ma, Dengke; Jin, Xiaolian; Fang, LC; Ju, Wenliang; Guo, Liang] Chinese Acad Sci, Inst Soil & Water Conservat, State Key Lab Soil Eros & Dryland Farming Loess Pl, Minist Water Resources, Yangling 712100, Peoples R China.;[Ju, Wenliang] Tsinghua Univ, Sch Environm, Beijing, Peoples R China.;[Fang, Linchuan] Wuhan Univ Technol, Key Lab Green Utilizat Crit Nonmet Mineral Resourc, Minist Educ, Wuhan, Peoples R China.;[Shen, Guoting; Blagodatskaya, Evgenia] UFZ Helmholtz Ctr Environm Res, Dept Soil Ecol, Halle, Saale, Germany.;[Delgado-Baquerizo, Manuel; Zhou, Guiyao] Inst Recursos Nat & Agrobiol Sevilla IRNAS, Lab Biodivers & Funcionamiento Ecosistem, CSIC, Seville, Spain.
通讯机构:
[Fang, LC ] C;Chinese Acad Sci, Inst Soil & Water Conservat, State Key Lab Soil Eros & Dryland Farming Loess Pl, Minist Water Resources, Yangling 712100, Peoples R China.
关键词:
carbon sequestration;grasslands;grazing exclusion;microbial communities and functions;nitrogen and phosphorus accumulation;soil aggregates
摘要:
We linked the soil microscale‐associated microbiomes with the carbon sequestration and biogeochemical cycling of livestock excluded grasslands for up to 36 years. Long‐term grazing exclusion reduced microbial diversity, community stability, and microbial functional genes associated with carbon sequestration and nutrient cycling. Moreover, we emphasize that the interaction between grazing exclusion and longevity as well as the structure of soil aggregates have substantial impacts the grassland biogeochemical cycles and global climate change in which the soil microbiome is involved. Abstract Grazing exclusion alters grassland soil aggregation, microbiome composition, and biogeochemical processes. However, the long‐term effects of grazing exclusion on the microbial communities and nutrient dynamics within soil aggregates remain unclear. We conducted a 36‐year exclusion experiment to investigate how grazing exclusion affects the soil microbial community and the associated soil functions within soil aggregates in a semiarid grassland. Long‐term (36 years) grazing exclusion induced a shift in microbial communities, especially in the <2 mm aggregates, from high to low diversity compared to the grazing control. The reduced microbial diversity was accompanied by instability of fungal communities, extended distribution of fungal pathogens to >2 mm aggregates, and reduced carbon (C) sequestration potential thus revealing a negative impact of long‐term GE. In contrast, 11–26 years of grazing exclusion greatly increased C sequestration and promoted nutrient cycling in soil aggregates and associated microbial functional genes. Moreover, the environmental characteristics of microhabitats (e.g., soil pH) altered the soil microbiome and strongly contributed to C sequestration. Our findings reveal new evidence from soil microbiology for optimizing grazing exclusion duration to maintain multiple belowground ecosystem functions, providing promising suggestions for climate‐smart and resource‐efficient grasslands.
摘要:
The construction of an all-in-one catalyst, in which the photosensitizer and the transition metal site are close to each other, is important for improving the efficiency of metallaphotoredox catalysis. However, the development of convenient synthetic strategies for the precise construction of an all-in-one catalyst remains a challenging task due to the requirement of precise installation of the catalytic sites. Herein, we have successfully established a facile bottom-up strategy for the direct synthesis of Ni(II)-incorporated covalent organic framework (COF), named LZU-713@Ni, as a versatile all-in-one metallaphotoredox catalyst. LZU-713@Ni showed excellent activity and recyclability in the photoredox/nickel-catalyzed C-O, C-S, and C-P cross-coupling reactions. Notably, this catalyst displayed a better catalytic activity than its homogeneous analogues, physically mixed dual catalyst system, and, especially, LZU-713/Ni which was prepared through post-synthetic modification. The improved catalytic efficiency of LZU-713@Ni should be attributed to the implementation of bottom-up strategy, which incorporated the fixed, ordered, and abundant catalytic sites into its framework. This work sheds new light on the exploration of concise and effective strategies for the construction of multifunctional COF-based photocatalysts. We developed a facile bottom-up strategy to synthesize Ni(II)-incorporated covalent organic framework (LZU-713@Ni) as heterogeneous all-in-one metallaphotoredox catalyst. LZU-713@Ni showed excellent activity and recyclability in photoredox/nickel-catalyzed C-O, C-S, and C-P cross-coupling reactions. The superiority of bottom-up strategy was exemplified by the increased activity of LZU-713@Ni compared to both the dual catalyst system and LZU-713/Ni prepared via post-synthetic modification.image
作者机构:
[Xia, Sijia; Zhang, Xiongjun] Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Peoples R China.;[Qiu, Duo] Wuhan Inst Technol, Sch Math & Phys, Wuhan 430205, Peoples R China.;[Zhang, Xiongjun] Cent China Normal Univ, Hubei Key Lab Math Sci, Wuhan 430079, Peoples R China.
通讯机构:
[Qiu, D ] W;Wuhan Inst Technol, Sch Math & Phys, Wuhan 430205, Peoples R China.
摘要:
In this paper, we study the problem of a batch of linearly correlated image alignment, where the observed images are deformed by some unknown domain transformations, and corrupted by additive Gaussian noise and sparse noise simultaneously. By stacking these images as the frontal slices of a third-order tensor, we propose to utilize the tensor factorization method via transformed tensor-tensor product to explore the low-rankness of the underlying tensor, which is factorized into the product of two smaller tensors via transformed tensor-tensor product under any unitary transformation. The main advantage of transformed tensor-tensor product is that its computational complexity is lower compared with the existing literature based on transformed tensor nuclear norm. Moreover, the tensor l(p) (0 < p < 1) norm is employed to characterize the sparsity of sparse noise and the tensor Frobenius norm is adopted to model additive Gaussian noise. A generalized Gauss-Newton algorithm is designed to solve the resulting model by linearizing the domain transformations, and a proximal Gauss-Seidel algorithm is developed to solve the corresponding subproblem. Furthermore, the convergence of the proximal Gauss-Seidel algorithm is established according to Kurdyka-Lojasiewicz property, whose convergence rate is also analyzed. Extensive numerical examples on real-world image datasets are carried out to demonstrate the superior performance of the proposed method as compared to several state-of-the-art methods in both accuracy and computational time.
作者机构:
[Chen, Jiayong; Zhong, Yize; Zhou, Guangzhen] Cent China Normal Univ, Sch Phys Educ & Sports, Wuhan 430070, Hubei, Peoples R China.
通讯机构:
[Chen, JY ] C;Cent China Normal Univ, Sch Phys Educ & Sports, Wuhan 430070, Hubei, Peoples R China.
关键词:
Data mining;Personalized teaching;Recommendation of teaching resources;Fuzzy clustering algorithm
摘要:
Due to the fast-growing Internet speed, processing power, and the use of sophisticated algorithms, information is generated at a very fast speed. This information is broad in scope and covers a variety of fields, including the medical field, transportation sector, business firms, and education institutes. Due to the abundance of information, it is challenging to identify useful materials in general, but finding the right materials for students is particularly challenging. To address this issue, this paper aims to study the design of a personalized sports teaching resource recommendation system using a fuzzy clustering technique. To do so, we collected relevant data from entities such as students and teachers, which includes a range of attributes related to physical education, including curricular materials, student profiles, past performance records, and resource metadata. The collected data were then preprocessed to prepare it for further analysis. The features, preferences, and learning styles of each student are examined to develop student profiles based on the data that have been collected. A database schema was created that stored all the information related to physical education teaching resources, students, and teachers. The fuzzy C-means clustering algorithm is used to improve the collaborative filtering recommendation algorithm and reduce the data sparsity of the teaching resources recommendation algorithm. Through a series of experiments, it has been proven that the system designed in this paper can recommend suitable learning resources for different learners and has good performance. At the same time, the recommended method has higher recommendation accuracy and can effectively improve the quality of physical education teaching.
作者机构:
[Su, Kuangxi] Xinyang Normal Univ, Sch Math & Stat, Xinyang, Peoples R China.;[Yao, Yinhong] Capital Univ Econ & Business, Sch Management & Engn, Beijing, Peoples R China.;[Zheng, Chengli] Cent China Normal Univ, Sch Econ & Business Adm, Wuhan, Peoples R China.;[Xie, Wenzhao] Changjiang Secur Co Ltd, Wuhan, Peoples R China.
通讯机构:
[Zheng, C.] S;School of Economics and Business Administration, China
关键词:
Correlation coefficient test;Empirical mode decomposition;Financial data denoising;Portfolio selection
期刊:
Journal of Hazardous Materials,2024年465:133009 ISSN:0304-3894
通讯作者:
Jia, Falong
作者机构:
[Zhang, Lizhi; Guo, Furong; Li, Donglei; Zhang, Yuhang; She, Liang; Ai, Zhihui; Liu, Xiao] College of Chemistry, Central China Normal University, Wuhan 430079, PR China;[Jia, Falong] College of Chemistry, Central China Normal University, Wuhan 430079, PR China. Electronic address: fljia@ccnu.edu.cn
通讯机构:
[Jia, Falong] C;College of Chemistry, Central China Normal University, Wuhan 430079, PR China. Electronic address:
关键词:
Cu(II)-EDTA;Decomplexation;Ferrous formate shell;Oxidative degradation;Zero-valent iron
摘要:
Heavy metal complexes in industrial wastewater are challenging to be removed by conventional methods arising from their stable chelating structure. In this study, zero-valent iron (ZVI) was ball-milled with tiny formic acid (FA), and the as-prepared sample (FA-ZVI(bm)) was attempted to eliminate a model heavy metal complex of Cu(II)-ethylenediaminetetraacetic acid (Cu(II)-EDTA). The addition of FA to ball-milling could dramatically enhance the performance of ball-milled ZVI (ZVI(bm)) towards Cu(II)-EDTA removal and increase the removal rate constant by 80 times. This conspicuous improvement of Cu(II)-EDTA elimination was attributed to the ferrous formate (Fe(HCOO)(2)) shell formed on the surface of FA-ZVI(bm). Results revealed that the Fe(HCOO)(2) shell facilitated the activation of O(2) to reactive oxygen species (ROS) and the leaching of Fe(3+). Cu(II)-EDTA was decomplexed through both oxidative destruction and Fe(3+) replacement, and the released Cu(2+) was reduced by FA-ZVI(bm) and immobilized synchronously. Meanwhile, the ligands underwent oxidative degradation by ROS, thus avoiding the re-chelation ecological risk. Impressively, FA-ZVI(bm) could achieve cyclic treatment of actual copper complex wastewater and possessed promising advantage in treatment cost. This study would offer a promising approach for eliminating Cu(II)-EDTA through EDTA ligands degradation and synchronous Cu(II) removal, moreover to shed light on the decomplexation mechanism.
通讯机构:
[Ding, XF ] C;Cent China Normal Univ CCNU, Sch Psychol, Wuhan 430079, Peoples R China.
摘要:
Previous evolutionary perspectives proposed that the space-time mapping on the sagittal axis originates from visuo-locomotion coupling when walking/running forward. Accordingly, the congenitally blind could not have developed a sagittal mental timeline if the latter depends on such a visuo-locomotion coupling. However, this conclusion was reached in only a single empirical study (Rinaldi et al. in J Exp Psychol General 147:444-450, 2018), and its theoretical underpinnings are not entirely convincing as locally static and continuous auditory input undergoes a relatively similar change as function of self-locomotion, but this type of sensory-locomotion coupling is spared even in congenital blindness. Therefore, the present study systematically explored whether the congenitally blind show space-time mappings on the sagittal axis using different paradigms in three experiments. In Experiment 1, using a typical implicit RT task, the congenitally blind showed the same preferred space-time mapping in the sagittal dimension as normally sighted participants did. In Experiment 2, this space-time mapping occurred even automatically when temporal relations were task-irrelevant in a naming task. In Experiment 3, in an explicit space-time mapping task, the congenitally blind were more likely to locate the past behind and the future in front of their bodies. Moreover, most blind participants used spatial metaphors for their space-time mapping on the sagittal axis. These results supported the conclusion that the congenitally blind have a sagittal mental timeline, and that their sensory-locomotion coupling experience was either more similar to that of sighted participants or not critical for the space-time mapping. The present study, thus, also helps to clarify the origin of the sagittal mental timeline.
摘要:
Abstract This study examined the role of cognitive flexibility and collective coping in the relationship between adult attachment and life satisfaction while comparing Black, Indigenous, and People of Color (BIPOC; n = 187) and White (n = 135) groups. Result showed that the relationship between attachment anxiety and life satisfaction was mediated via cognitive flexibility and collective coping only in the BIPOC group. This study informs culturally responsive attachment‐based counseling and advances literature from a decolonial perspective. Resumen Este estudio examinó el papel de la flexibilidad cognitiva y el afrontamiento colectivo en la relación entre el apego adulto y la satisfacción vital, comparando grupos de personas negras, indígenas y de color (BIPOC, por sus siglas en inglés; n = 187) y blancas (n = 135). Los resultados mostraron que la flexibilidad cognitiva y el afrontamiento colectivo mediaron en la relación entre la ansiedad de apego y la satisfacción vital, solo en el grupo BIPOC. Este estudio presenta información relevante para la consejería basada en el apego y culturalmente sensible y expande la literatura desde una perspectiva decolonial.
作者机构:
[Zhang, Xiangqian; Chen, Yu; Deng, GZ; Feng, Huili; Deng, Ganzhen; Zhou, Qingqing] Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China.;[Liu, Shuang] Wuhan Univ Technol, Sch Mat Sci & Engn, 122 Luoshi Rd, Wuhan 430070, Peoples R China.;[Li, JR; Li, Junrong; Li, Chonglu] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticides, Wuhan 430079, Peoples R China.;[Guan, Xiaofang] Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan 430081, Peoples R China.;[Deng, Yun; Fu, Cheng] Jianghan Univ, Key Lab Optoelect Chem Mat & Devices, Minist Educ, Wuhan 430056, Peoples R China.
通讯机构:
[Liu, S ] W;[Li, JR ] C;[Deng, GZ ] H;Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China.;Wuhan Univ Technol, Sch Mat Sci & Engn, 122 Luoshi Rd, Wuhan 430070, Peoples R China.
摘要:
High efficiency, stability, long emission wavelength (NIR-II), and good biocompatibility are crucial for photosensitizers in phototherapy. However, current Food and Drug Administration (FDA)-approved organic fluorophores exhibit poor chemical stability and photostability as well as short emission wavelength, limiting their clinical usage. To address this, we developed Se-IR1100, a novel organic photosensitizer with a photostable and thermostable benzobisthiadiazole (BBTD) backbone. By incorporating selenium as a heavy atom and constructing a D-A-D structure, Se-IR1100 exhibits a maximum fluorescence emission wavelength of 1100 nm. Compared with FDA-approved indocyanine green (ICG), DSPE-PEGylated Se-IR1100 nanoparticles exhibit prominent photostability and long-lasting photothermal effects. Upon 808 nm laser irradiation, Se-IR1100 NPs efficiently convert light energy into heat and reactive oxygen species (ROS), inducing cancer cell death in cellular studies and living organisms while maintaining biocompatibility. With salient photostability and a photothermal conversion rate of 55.37%, Se-IR1100 NPs hold promise as a superior photosensitizer for diagnostic and therapeutic agents in oncology. Overall, we have designed and optimized a multifunctional photosensitizer Se-IR1100 with good biocompatibility that performs NIR-II fluorescence imaging and phototherapy. This dual-strategy method may offer novel approaches for the development of multifunctional probes using dual-strategy or even multi-strategy methods in bioimaging, disease diagnosis, and therapy. High efficiency, stability, long emission wavelength (NIR-II), and good biocompatibility are crucial for photosensitizers in phototherapy.
期刊:
Journal of Youth and Adolescence,2024年 ISSN:0047-2891
通讯作者:
Zhang, L
作者机构:
[Liang, Heting; Cai, Zhihui; Xiong, Fen; Zhang, Lin] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Liang, Heting; Cai, Zhihui; Xiong, Fen; Zhang, Lin] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan, Peoples R China.;[Liang, Heting; Cai, Zhihui; Xiong, Fen; Zhang, Lin] Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan, Peoples R China.;[Bjureberg, Johan] Karolinska Inst, Ctr Psychiat Res, Stockholm Cty Council, Stockholm, Sweden.;[Bjureberg, Johan] Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden.
通讯机构:
[Zhang, L ] C;Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan, Peoples R China.;Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan, Peoples R China.
关键词:
Emotion recognition;Internalizing problems;Children and adolescents;Moderation;Three-level meta-analysis
摘要:
Numerous studies have explored the link between how well youth recognize emotions and their internalizing problems, but a consensus remains elusive. This study used a three-level meta-analysis model to quantitatively synthesize the findings of existing studies to assess the relationship. A moderation analysis was also conducted to explore the sources of research heterogeneity. Through a systematic literature search, a total of 42 studies with 201 effect sizes were retrieved for the current meta-analysis, and 7579 participants were included. Emotion recognition was negatively correlated with internalizing problems. Children and adolescents with weaker emotion recognition skills were more likely to have internalizing problems. In addition, this meta-analysis found that publication year had a significant moderating effect. The correlation between emotion recognition and internalizing problems decreased over time. The degree of internalizing problems was also found to be a significant moderator. The correlation between emotion recognition and internalizing disorders was higher than the correlation between emotion recognition and internalizing symptoms. Deficits in emotion recognition might be relevant for the development and/or maintenance of internalizing problems in children and adolescents. The overall effect was small and future research should explore the clinical relevance of the association.
关键词:
oriented split graphs;planar digraphs;Seymour's second neighbourhood conjecture;Sullivan's second neighbourhood conjecture
摘要:
Abstract For a vertex x $x$ of a digraph, d + ( x ) ${d}^{+}(x)$ (d − ( x ) ${d}^{-}(x)$, respectively) is the number of vertices at distance 1 from (to, respectively) x $x$ and d + + ( x ) ${d}^{++}(x)$ is the number of vertices at distance 2 from x $x$. In 1995, Seymour conjectured that for any oriented graph D $D$ there exists a vertex x $x$ such that d + ( x ) ≤ d + + ( x ) ${d}^{+}(x)\le {d}^{++}(x)$. In 2006, Sullivan conjectured that there exists a vertex x $x$ in D $D$ such that d − ( x ) ≤ d + + ( x ) ${d}^{-}(x)\le {d}^{++}(x)$. We give a sufficient condition in terms of the number of transitive triangles for an oriented graph to satisfy Sullivan's conjecture. In particular, this implies that Sullivan's conjecture holds for all orientations of planar graphs and triangle‐free graphs. An oriented graph D $D$ is an oriented split graph if the vertices of D $D$ can be partitioned into vertex sets X $X$ and Y $Y$ such that X $X$ is an independent set and Y $Y$ induces a tournament. We also show that the two conjectures hold for some families of oriented split graphs, in particular, when Y $Y$ induces a regular or an almost regular tournament.
作者机构:
[Shu, C; Xuan, Chenglong; Shu, Chao; Liu, Meng; Ouyang, Xinke] Cent China Normal Univ CNNU, Coll Chem,Engn Res Ctr Photoenergy Utilizat Pollut, CCNU UOttawa Joint Res Ctr,Natl Key Lab Green Pest, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Shu, C; Shu, Chao] Wuhan Inst Photochem & Technol, 7 North Bingang Rd, Wuhan 430083, Hubei, Peoples R China.
通讯机构:
[Shu, C ] C;Cent China Normal Univ CNNU, Coll Chem,Engn Res Ctr Photoenergy Utilizat Pollut, CCNU UOttawa Joint Res Ctr,Natl Key Lab Green Pest, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;Wuhan Inst Photochem & Technol, 7 North Bingang Rd, Wuhan 430083, Hubei, Peoples R China.
摘要:
The term "cyclic architectures" refers to a class of molecules that are highly valuable and play significant roles in organic compounds. Therefore, there is growing interest in researching the development of efficient and straightforward methods for constructing these complex structures. Photoinduced radical-polar crossover cyclization (RPCC) of bifunctional alkenes represents a class of reactions that are of great synthetic utility because they show high chemoselectivity, broad functional group tolerance and proceed under mild conditions to produce high-value cyclic products with precise alkene design. This mini-review summarizes the recent representative advances in the development of RPCC over the past two decades through different synthetic strategies in the reactions, highlighting their product diversity, selectivity and applicability, and the mechanistic rationale where possible. The intention is to provide readers with a comprehensive understanding of the current state-of-play in this field and contribute to future research efforts. Photoinduced radical-polar crossover cyclization (RPCC) of bifunctional alkenes is of high synthetic utility to produce cyclic products with precise alkene design. This review summarizes the recent representative advances in the field of RPC.
摘要:
Brain storm optimization (BSO) is a population-based intelligence algorithm for optimization problems, which has attracted researchers' growing attention due to its simplicity and efficiency. An improved BSO, called CIBSO, is presented in this article. First of all, a new grouping method, in which the population is partitioned into chunks according to the fitness and recombined to groups, is developed to balance each group with same quality-level. Afterwards, a new mutation strategy is designed in CIBSO and a learning mechanism is used to adaptively select appropriate strategy. Experiments on the CEC2014 test suite indicate that CIBSO is better or at least competitive performance against the compared BSO variants.
作者机构:
[Li, Weifang; Liu, Ke; Lei, Ming; Min, Jinrong; Xiao, Yuqing; Zhang, Ming] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
通讯机构:
[Liu, K; Min, JR ] C;Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
摘要:
Nuclear respiratory factor 1 (NRF1) regulates the expression of genes that are vital for mitochondrial biogenesis, respiration, and various other cellular processes. While NRF1 has been reported to bind specifically to GC-rich promoters as a homodimer, the precise molecular mechanism governing its recognition of target gene promoters has remained elusive. To unravel the recognition mechanism, we have determined the crystal structure of the NRF1 homodimer bound to an ATGCGCATGCGCAT dsDNA. In this complex, NRF1 utilizes a flexible linker to connect its dimerization domain (DD) and DNA binding domain (DBD). This configuration allows one NRF1 monomer to adopt a U-turn conformation, facilitating the homodimer to specifically bind to the two TGCGC motifs in the GCGCATGCGC consensus sequence from opposite directions. Strikingly, while the NRF1 DBD alone could also bind to the half-site (TGCGC) DNA of the consensus sequence, the cooperativity between DD and DBD is essential for the binding of the intact GCGCATGCGC sequence and the transcriptional activity of NRF1. Taken together, our results elucidate the molecular mechanism by which NRF1 recognizes specific DNA sequences in the promoters to regulate gene expression. Graphical Abstract
期刊:
ACM Transactions on Knowledge Discovery from Data,2024年18(1):1–22 ISSN:1556-4681
作者机构:
[Guoquan Liu; Po Hu] School of Computer Science, Central China Normal University, China;[Huan Wang] College of Informatics, Huazhong Agricultural University, PKU-Wuhan Institute for Artificial Intelligence, China
关键词:
Transfer learning;type-shared knowledge;link prediction
摘要:
Link prediction has received increased attention in social network analysis. One of the unique challenges in heterogeneous social networks is link prediction in new link types without verified link information, such as recommending products to new overseas groups. Existing link prediction models tend to learn type-specific knowledge on specific link types and predict missing or future links on the same link types. However, because of the uncertainty of new link types in the evolving process of social networks, it is difficult to collect sufficient verified link information in new link types. Therefore, we propose the Transferable Domain Adversarial Network (TDAN) based on transfer learning to handle the challenge. TDAN exploits transferable type-shared knowledge in historical link types to help predict the unobserved links in new link types. TDAN mainly comprises a structural encoder, a domain discriminator, and an optimization decoder. The structural encoder learns the link representations in a heterogeneous social network. Subsequently, to learn transferable type-shared knowledge, the domain discriminator distinguishes link representations into different link types while minimizing the differences between type-specific knowledge in adversarial training. Inspired by the denoising auto-encoder, the optimization decoder reconstructs the learned type-shared knowledge to eliminate the noise generated during the adversarial training. Extensive experiments on Facebook and YouTube show that TDAN can outperform the state-of-the-art models.
作者:
Shi Dong;Xueyun Tao;Rui Zhong;Zhifeng Wang;Mingzhang Zuo;...
期刊:
IEEE Transactions on Learning Technologies,2024年:1-17 ISSN:1939-1382
作者机构:
[Shi Dong; Xueyun Tao; Rui Zhong; Zhifeng Wang; Mingzhang Zuo; Jianwen Sun] Faculty of Artificial Intelligence in Education, Central China Normal University, Wuhan, China
摘要:
Higher education is rapidly growing in the online learning landscape. However, current personalized recommendation techniques struggle with precise extraction of complex mathematical semantics, hindering accurate perception of learners' cognitive states and relevance of recommendations. This paper proposes a framework for extracting complex mathematical semantics and providing personalized exercise recommendations. We design a tree-based position encoding method to enhance the accuracy of positional representation for mathematical expressions in pre-trained model, aiming to improve the performance of downstream tasks. We propose an automatic method for extracting knowledge attributes based on expert annotations, enabling interpretable cognitive diagnosis. Furthermore, we employ sequential pattern mining to discover the knowledge usage patterns in exercises, generate learning paths using a multi-layer knowledge graph, and leverage cognitive diagnostic results to enhance the relevance of recommendations. Experimental results show a 2.0% improvement in mathematical symbol embedding on mathematical formula retrieval tasks, and knowledge attribute extraction accuracy ranging from 66.5% to 81.7%. Learners' post-test scores significantly improve during group testing, with good consistency between online cognitive diagnosis and self-diagnosis. IEEE
期刊:
Journal of Natural Products,2024年87(1):141-151 ISSN:0163-3864
通讯作者:
Ruan, HL
作者机构:
[Ruan, Han-Li; Hu, Jia-Yun; Qin, Chun-Lun; Chang, Jin-Ling; Pei, Jiao; Ouyang, Qian-Xi; Ruan, HL; Zhou, Yin-Hui] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China.;[Meng, Xiang-Gao] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构:
[Ruan, HL ] H;Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China.
摘要:
Twelve new austalide meroterpenoids (1-12) were isolated from the endophytic fungus Diaporthe sp. XC1211. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of compounds 1, 3, 4, and 6 were established by single-crystal X-ray diffraction, whereas those for the others were established by experimental electronic circular dichroism (ECD) data analysis. Compounds 1-12 represent a rare class of austalides with a 24 alpha-CH3. Compounds 2 and 5 demonstrated potent proliferation inhibitory effects against LPS-induced B cells with IC50 values of 6.7 (SI = 3.6) and 3.8 (SI > 13) mu M, respectively. Compounds 2 and 5 decreased the secretion of IL-6 in LPS-induced B cells in a dose-dependent manner.