摘要:
A mild strategy for the synthesis of boron‐handled pyrazoles through photocatalytic cascade radical cyclization of LBRs (Lewis base‐boryl radicals) with vinyldiazo reagents is described here. The reaction starts with the addition of LBRs at diazo site, followed by intramolecular radical cyclization to access a wide range of important boron‐handled pyrazoles in good to excellent yields. Control experiments, together with detailed mechanism studies well explain the observed reactivity. Abstract Vinyldiazo compounds are one of the most important synthons in the construction of a cyclic ring. Most photochemical transformations of vinyldiazo compounds are mainly focusing on utilization of their C═C bond site, while reactions taking place at terminal nitrogen atom are largely unexplored. Herein, a photocatalytic cascade radical cyclization of LBRs with vinyldiazo reagents through sequential B─N/C─N bond formation is described. The reaction starts with the addition of LBRs (Lewis base–boryl radicals) at diazo site, followed by intramolecular radical cyclization to access a wide range of important boron‐handled pyrazoles in good to excellent yields. Control experiments, together with detailed mechanism studies well explain the observed reactivity. Further studies demonstrate the utility of this approach for applications in pharmaceutical and agrochemical research.
关键词:
aridity;biogeography;climate change;deep soil;microbial biodiversity and function;soil depth;water heterogeneity
摘要:
Our results contribute to broader and deeper knowledge of climate change microbiology in deep soil environments under future climate scenarios. We proposes a potential mechanism for the association between climate aridity and deep soil microbes; that is, when the external aridity changes, water evapotranspiration (including plant transpiration and soil water evaporation) is directly and indirectly (e.g., changes in rooting depths and soil texture) affected, and a volumetric soil moisture gradient (related to soil porosity) is formed to primarily drive microorganisms in deep soil. Abstract Microbes inhabiting deep soil layers are known to be different from their counterpart in topsoil yet remain under investigation in terms of their structure, function, and how their diversity is shaped. The microbiome of deep soils (>1 m) is expected to be relatively stable and highly independent from climatic conditions. Much less is known, however, on how these microbial communities vary along climate gradients. Here, we used amplicon sequencing to investigate bacteria, archaea, and fungi along fifteen 18‐m depth profiles at 20–50‐cm intervals across contrasting aridity conditions in semi‐arid forest ecosystems of China's Loess Plateau. Our results showed that bacterial and fungal α diversity and bacterial and archaeal community similarity declined dramatically in topsoil and remained relatively stable in deep soil. Nevertheless, deep soil microbiome still showed the functional potential of N cycling, plant‐derived organic matter degradation, resource exchange, and water coordination. The deep soil microbiome had closer taxa–taxa and bacteria–fungi associations and more influence of dispersal limitation than topsoil microbiome. Geographic distance was more influential in deep soil bacteria and archaea than in topsoil. We further showed that aridity was negatively correlated with deep‐soil archaeal and fungal richness, archaeal community similarity, relative abundance of plant saprotroph, and bacteria–fungi associations, but increased the relative abundance of aerobic ammonia oxidation, manganese oxidation, and arbuscular mycorrhizal in the deep soils. Root depth, complexity, soil volumetric moisture, and clay play bridging roles in the indirect effects of aridity on microbes in deep soils. Our work indicates that, even microbial communities and nutrient cycling in deep soil are susceptible to changes in water availability, with consequences for understanding the sustainability of dryland ecosystems and the whole‐soil in response to aridification. Moreover, we propose that neglecting soil depth may underestimate the role of soil moisture in dryland ecosystems under future climate scenarios.
作者机构:
[Shu, C; Deng, Zhengxi; Xuan, Chenglong; Zhu, Zhiming; Shu, Chao] Cent China Normal Univ CCNU, Coll Chem, Engn Res Ctr Photoenergy Utilizat Pollut Control &, CCNU uOttawa Joint Res Ctr,Natl Key Lab Green Pest, Wuhan 430070, Hubei, Peoples R China.;[Shu, C; Deng, Zhengxi; Xuan, Chenglong; Zhu, Zhiming; Shu, Chao] Anhui Normal Univ, Key Lab Funct Mol Solids, Minist Educ, Wuhu 241000, Anhui, Peoples R China.
通讯机构:
[Shu, C ] C;Cent China Normal Univ CCNU, Coll Chem, Engn Res Ctr Photoenergy Utilizat Pollut Control &, CCNU uOttawa Joint Res Ctr,Natl Key Lab Green Pest, Wuhan 430070, Hubei, Peoples R China.;Anhui Normal Univ, Key Lab Funct Mol Solids, Minist Educ, Wuhu 241000, Anhui, Peoples R China.
摘要:
A thermoinduced radical homolytic substitution cyclization of alkenyl tethered sulfinate esters was displayed under mild metal-free conditions, enabling the functionalization of alkenes and leading to structurally diverse value-added sultine products. The process utilizes readily available substrates using inexpensive 5% benzoyl peroxide (BPO) as an initiator to generate functionalized sultines with broad functional group tolerance in medium to excellent yields in a highly atom-economical manner. In addition, the obtained sultines could be further readily functionalized toward valuable sultone frameworks in one pot. A thermo-catalytic radical chain process was proposed based on mechanistic studies.
期刊:
Journal of Proteome Research,2024年23(1):368-376 ISSN:1535-3893
通讯作者:
Wan, CH
作者机构:
[Wang, Yi; Wan, Cuihong; Wan, CH; Peng, Mingbo; Yi, Zi; Li, Shenglan; Zhou, Yutian] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;[Wang, Yi; Wan, Cuihong; Wan, CH; Peng, Mingbo; Yi, Zi; Li, Shenglan; Zhou, Yutian] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Wan, CH ] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
摘要:
The low-molecular-weight proteins (LMWP) in serum and plasma are related to various human diseases and can be valuable biomarkers. A small open reading frame-encoded peptide (SEP) is one kind of LMWP, which has been found to function in many bioprocesses and has also been found in human blood, making it a potential biomarker. The detection of LMWP by a mass spectrometry (MS)-based proteomic assay is often inhibited by the wide dynamic range of serum/plasma protein abundance. Nanoparticle protein coronas are a newly emerging protein enrichment method. To analyze SEPs in human serum, we have developed a protocol integrated with nanoparticle protein coronas and liquid chromatography (LC)/MS/MS. With three nanoparticles, TiO2, Fe3O4@SiO2, and Fe3O4@SiO2@TiO2, we identified 164 new SEPs in the human serum sample. Fe3O4@SiO2 and a nanoparticle mixture obtained the maximum number and the largest proportion of identified SEPs, respectively. Compared with acetonitrile-based extraction, nanoparticle protein coronas can cover more small proteins and SEPs. The magnetic nanoparticle is also fit for high-throughput parallel protein separation before LC/MS. This method is fast, efficient, reproducible, and easy to operate in 96-well plates and centrifuge tubes, which will benefit the research on SEPs and biomarkers.
作者机构:
BESⅢ Collaboration;Institute of High Energy Physics;G.I.Budker Institute of Nuclear Physics SB RAS (BINP);the Novosibirsk State University;Uppsala University
摘要:
We present a search for the lepton flavor violating decay J/ψ→e±μ?using 8.998 × 10~9J/ψ events collected with the BESⅢ detector at the BEPCⅡ e+e-storage ring.No excess of signal above background is observed;we therefore set an upper limit on the branching fraction of B(J/ψ→ e±μ?) <4.5 × 10-9 at the 90% confidence level.Improving the previous best result by a factor of more than 30,this measurement places the most stringent limit to date on lepton flavor violation in the heavy quarkonium sector.
期刊:
Journal of Children and Media,2023年17(4):409-425 ISSN:1748-2798
通讯作者:
Wang, FX;Li, H
作者机构:
[Cao, Xinyun; Wang, Fuxing; Tong, Yu] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Li, Hui] Cent China Normal Univ, Sch Educ, Wuhan, Peoples R China.;[Wang, Fuxing; Wang, FX] Cent China Normal Univ, Sch Psychol, 382 Xiongchu Ave, Wuhan BLDG 8073, Hubei, Peoples R China.;[Li, Hui] Cent China Normal Univ, Sch Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Li, H ; Wang, FX ] C;Cent China Normal Univ, Sch Psychol, 382 Xiongchu Ave, Wuhan BLDG 8073, Hubei, Peoples R China.;Cent China Normal Univ, Sch Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要:
Characters in educational videos have been shown to help children learn and transfer knowledge. The aim of this study is to explore the influence of realism and familiarity of characters on children's video learning. The participants were 90 4- to 6-year-olds. The children watched a video in which a character demonstrated how to construct simple gears, and then completed the same task to test the effect of the character's realism and familiarity on their learning and transfer of STEM knowledge. A 2 (high-reality vs. low-reality) x 2 (familiar, unfamiliar) experiment was adopted. The results showed that children learned STEM material better from live-action human characters than from animated animal characters. However, the familiarity of the character did not influence children's learning, and the parasocial relationship between children and the character also did not improve learning. The findings suggest that the realism of the characters, not their familiarity, is key in helping children learn from educational videos. IMPACT SUMMARYPrior State of Knowledge: Children's learning from screen-based educational media can be influenced by characteristics of the characters. Less is known about whether realistic and familiar characteristics improve children's screen learning.Novel Contributions: We created four characters based on combined realism and familiarity to explore whether some characters are better than others at promoting learning STEM information.Practical Implications: Our findings are relevant to producers of educational videos. Compared to animated characters, live-action human characters may better help children ages 4 to 6 years to learn from these videos.
作者:
Van Hulse, C.;Adkins, J. K.;Akiba, Y.;Albataineh, A.;Amaryan, M.;...
期刊:
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment,2023年1056:168563 ISSN:0168-9002
通讯作者:
Van Hulse, C
作者机构:
[Niccolai, S.; Dupre, R.; Van Hulse, C.; Hoballah, M.; Wang, P. K.; Voutier, E.; Marchand, D.; Camacho, C. Munoz] Univ Paris Saclay, IJCLab, CNRS, IN2P3, Orsay, France.;[Mkrtchyan, H.; Miyachi, Y.; Hoghmrtsyan, A.; Tadevosyan, V.; Movsisyan, A.; Marukyan, H.; Mkrtchyan, A.] A Alikhanyan Natl Lab, Yerevan, Armenia.;[Chang, W. -C.; Lin, C. -H.] Acad Sinica, Inst Phys, Taipei, Taiwan.;[Grau, N.] Augustana Univ, Sioux Falls, SD USA.;[Citron, Z.] Ben Gurion Univ Negev, Beer Sheva, Israel.
通讯机构:
[Van Hulse, C ] U;Univ Alcala, Alcala De Henares, Madrid, Spain.
关键词:
ECCE;Electron-ion collider;Semi-inclusive deep-inelastic scattering;Helicity parton distribution functions
摘要:
The evaluation of the measurement of double-spin asymmetries for charge-separated pions and kaons produced in deep-inelastic scattering from the proton using the ECCE detector design concept is presented, for the combinations of lepton and hadron beam energies of 5 × 41 GeV 2 and 18 × 275 GeV 2 . The study uses unpolarised simulated data that are processed through a full GEANT simulation of the detector. These data are then reweighted at the parton level with DSSV helicity distributions and DSS fragmentation functions, in order to generate the relevant asymmetries, and subsequently analysed. The performed analysis shows that the ECCE detector concept provides the resolution and acceptance, with a broad coverage in kinematic phase space, needed for a robust extraction of asymmetries. This, in turn, allows for a precise extraction of sea-quark helicity distributions.
作者:
Liu, Liping;Wei, Yantao;Wang, Yue;Yao, Huang;Chen, Di
期刊:
Remote Sensing,2023年15(15) ISSN:2072-4292
通讯作者:
Yao, H
作者机构:
[Yao, Huang; Wang, Yue; Wei, Yantao; Chen, Di; Liu, Liping] Cent China Normal Univ, Fac Artificial Intelligence Educ, Wuhan 430079, Peoples R China.;[Wei, Yantao] Cent China Normal Univ, Hubei Res Ctr Educ Informat, Wuhan 430079, Peoples R China.;[Yao, H] Cent China Normal Univ, Fac Artificial Intelligence Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Yao, H ] ;Cent China Normal Univ, Fac Artificial Intelligence Educ, Wuhan 430079, Peoples R China.
摘要:
Abstract: Detecting infrared (IR) small targets effectively and robustly is crucial for the tasks such as infrared searching and guarding. While methods based on the human vision system (HVS) have achieved great success in this field, detecting dim targets in complex backgrounds remains a challenge due to the multi-scale framework and over-simplified disparity calculations. In this paper, infrared small targets are detected with a novel local contrast measurement named double-layer patch-based contrast (DLPC). Firstly, we crafted an elaborated double-layer local contrast measure, to suppress the background, which can accurately measure the gray difference between the target and its surrounding complex background. Secondly, we calculated the absolute value of the grayscale difference between the target and the background in the diagonal directions as a weighting factor to further enhance the target. Then, an adaptive threshold on the DLPC was employed to extract the target from the IR image. The proposed method can detect small targets effectively with a fixed-scaled mask template while being computationally efficient. Experimental results in terms of background suppression factor (BSF), signal-to-clutter ratio gain (SCRG) and receiver operating characteristic (ROC) curve on five IR image datasets demonstrated that the proposed method has better detection performance compared to six state-of-the-art methods and is more robust in addressing complex backgrounds. Keywords: infrared image; target detection; local contrast; double-layer
摘要:
居鲁士大帝[Ciro il Grande,约公元前600/576年—前530年]是强大波斯帝国的缔造者,阿契美尼德王朝的第一位国王,古代世界最著名的君主之一。作为一位“东方”君主,他强势的征服在古希腊–罗马文化中留下了印...展开更多 居鲁士大帝[Ciro il Grande,约公元前600/576年—前530年]是强大波斯帝国的缔造者,阿契美尼德王朝的第一位国王,古代世界最著名的君主之一。作为一位“东方”君主,他强势的征服在古希腊–罗马文化中留下了印记。然而,作为一位波斯君主,欧洲文明的“他者”,居鲁士在历代欧洲艺术家笔下的呈现方式值得玩味。在文艺复兴时期的视觉艺术作品中,相较于古代世界其他著名统治者,如亚历山大、大卫和恺撒,居鲁士大帝的形象相对暧昧,也更为罕见。收起
作者机构:
[Sun, Qian; Wang, Dong; Wang, D; Xu, Xiaodong] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;[Wang, Dong; Wang, D] Shaanxi Univ Technol, Bioresources key Lab Shaanxi Prov, Hanzhong 723001, Shaanxi, Peoples R China.;[Li, Niya] Wuhan Sinoeco Ecol Sci & Technol Co Ltd, Wuhan 430000, Hubei, Peoples R China.;[Wang, Liang] Lanzhou Univ, Sch Ecol, Lanzhou, Gansu, Peoples R China.;[Wang, Liang] Adm Gansu Anxi Extraarid Desert Natl Nat Reserve, Guazhou, Gansu, Peoples R China.
通讯机构:
[Wang, D ] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;Shaanxi Univ Technol, Bioresources key Lab Shaanxi Prov, Hanzhong 723001, Shaanxi, Peoples R China.
摘要:
Corydalis mianxianensis, a new species of C. sect. Cheilanthifoliae Liden (Papaveracae), is described from Qinling-Daba mountains and adjacent Minshan mountains, central China. It is similar to C. moupinensis Franch., but it differs from the latter in racemes with 30-50(-70) flowers, spur being much shorter than limb of upper petal, and arcuate to strongly contorted fruits. These two species are also much different in stigma and ecology as well. In addition, we confirmed that the record of C. saxicola G.S.Bunting in Shaanxi Province as documented in the Chinese floras was a misidentification of this new species.