摘要：
Significance Statement This study has revealed an important role of OsTIL1 in maintaining the cell membrane integrity by regulating the 18:3‐containing glycerolipids biosynthesis and reducing reactive oxygen species damage under cold stress in rice seedlings. SUMMARY Lipocalins constitute a conserved protein family that binds to and transports a variety of lipids while fatty acid desaturases (FADs) are required for maintaining the cell membrane fluidity under cold stress. Nevertheless, it remains unclear whether plant lipocalins promote FADs for the cell membrane integrity under cold stress. Here, we identified the role of OsTIL1 lipocalin in FADs‐mediated glycerolipid remodeling under cold stress. Overexpression and CRISPR/Cas9 mediated gene edition experiments demonstrated that OsTIL1 positively regulated cold stress tolerance by protecting the cell membrane integrity from reactive oxygen species damage and enhancing the activities of peroxidase and ascorbate peroxidase, which was confirmed by combined cold stress with a membrane rigidifier dimethyl sulfoxide or a H2O2 scavenger dimethyl thiourea. OsTIL1 overexpression induced higher 18:3 content, and higher 18:3/18:2 and (18:2 + 18:3)/18:1 ratios than the wild type under cold stress whereas the gene edition mutant showed the opposite. Furthermore, the lipidomic analysis showed that OsTIL1 overexpression led to higher contents of 18:3‐mediated glycerolipids, including galactolipids (monoglactosyldiacylglycerol and digalactosyldiacylglycerol) and phospholipids (phosphatidyl glycerol, phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl serine and phosphatidyl inositol) under cold stress. RNA‐seq and enzyme linked immunosorbent assay analyses indicated that OsTIL1 overexpression enhanced the transcription and enzyme abundance of four ω‐3 FADs (OsFAD3‐1/3‐2, 7, and 8) under cold stress. These results reveal an important role of OsTIL1 in maintaining the cell membrane integrity from oxidative damage under cold stress, providing a good candidate gene for improving cold tolerance in rice.
期刊：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2024年146(9):6307-6316 ISSN：0002-7863
通讯作者：
Chen, FE;Zhou, H
作者机构：
[Zhao, Fei; Dong, Jianghu; Wang, Wei; Chen, Fen-Er; Yan, Qiongjiao; Xuan, Liangming; Chen, Qinlin; Fan, Rundong; Wang, Haifeng] Wuhan Inst Technol, Pharmaceut Res Inst, Sch Chem Engn & Pharm, Wuhan 430205, Peoples R China.;[Zhou, Hui] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Chen, Fen-Er] Fudan Univ, Engn Ctr Catalysis & Synth Chiral Mol, Dept Chem, Shanghai 200433, Peoples R China.;[Chen, Fen-Er] Shanghai Engn Ctr Ind Catalysis Chiral Drugs, Shanghai 200433, Peoples R China.
通讯机构：
[Zhou, H ] C;[Chen, FE ] W;Wuhan Inst Technol, Pharmaceut Res Inst, Sch Chem Engn & Pharm, Wuhan 430205, Peoples R China.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.;Fudan Univ, Engn Ctr Catalysis & Synth Chiral Mol, Dept Chem, Shanghai 200433, Peoples R China.
摘要：
Saturated hydrocarbon bonds are ubiquitous in organic molecules; to date, the selective functionalization of C(sp(3))-H bonds continues to pose a notorious difficulty, thereby garnering significant attention from the synthetic chemistry community. During the past several decades, a wide array of powerful new methodologies has been developed to enantioselectively modify C(sp(3))-H bonds that is successfully applied in asymmetric formation of diverse bonds, including C-C, C-N, and C-O bonds; nevertheless, the asymmetric C(sp(3))-H alkylation is elusive and, therefore, far less explored. In this work, we report a direct and robust strategy to construct highly valuable enantioenriched unnatural α-amino acid (α-AA) cognates and peptides by a copper-catalyzed enantioselective remote C(sp(3))-H alkylation of N-fluorocarboxamides and readily accessible glycine esters under ambient conditions. The key to success lies in the optically active Cu catalyst generated through the coordination of glycine derivatives to enantiopure bisphosphine/Cu(I) species, which is beneficial to the single electronic reduction of N-fluorocarboxamides and the subsequent stereodetermining alkylation. More importantly, all types (primary, secondary, tertiary, and even α-oxy) of δ-C(sp(3))-H bonds could be site- and stereospecifically activated by the kinetically favored 1,5-hydrogen atom transfer (1,5-HAT) step.
摘要：
Accurate wind speed forecasting is capable of increasing the stability of wind power system. Notably, there are numerous factors affecting wind speed, thus causing wind speed forecasting to be difficult. To address the above -mentioned challenge, a novel hybrid model integrating genetic algorithm (GA), variational mode decomposition (VMD), improved dung beetle optimization algorithm (IDBO), and Bidirectional long short-term memory network based on attention mechanism (BiLSTM-A) is proposed in this study to achieve satisfactory forecasting performance. In the proposed model, GA is adopted to optimize the VMD to eliminate noise and extract original series attributes. And the IDBO is adopted for hyperparameters selection for the BiLSTM-A. The proposed GA-VMD-IDBO-BiLSTM-A is compared with nine established comparable models, with the aim of verifying its forecasting performance. A series of experiments on four 1 -hour real wind series in Stratford are performed to assess the performance of the model. The MAPE of the four datasets forecasting results reached 1.4%, 2.4%, 3.5%, 2.4%. As indicated by the experimental results, GA-VMD can better process the data and improve the forecasting accuracy. IDBO can optimize the parameters of BiLSTM model and improve the forecasting performance. The dual -optimization wind speed forecasting model can obtain high accuracy and strong stability.
期刊：
Journal of Mathematical Analysis and Applications,2024年529(1):127609 ISSN：0022-247X
通讯作者：
Yang, YQ
作者机构：
[Zhang, Yan-fang] Huzhou Univ, Sch Sci, Huzhou 313000, Peoples R China.;[Yang, Yong-qiang] Cent China Normal Univ, Dept Math & Stat, Wuhan 430079, Peoples R China.
通讯机构：
[Yang, YQ ] C;Cent China Normal Univ, Dept Math & Stat, Wuhan 430079, Peoples R China.
关键词：
Self-affine sponge;Maximal power law;Component-counting measure
摘要：
Let (E, ) be a metric space and let hE (5) be the cardinality of the set of 5-connected components of E. In literature, in case of that E is a self-conformal set satisfying the open set condition or E is a self-affine Sierpinski sponge, necessary and sufficient condition is given for the validity of the relation hE(5) x 5- dimB E, when 5 & RARR; 0. In this paper, we generalize the above result to self-affine sponges of LalleyGatzouras type; actually in this case, we show that there exists a Bernoulli measure & mu; such that for any cylinder W, it holds that hW (5) x & mu;(W )5- dimB E, when 5 & RARR; 0.& COPY; 2023 Elsevier Inc. All rights reserved.
期刊：
CHEMISTRY-AN ASIAN JOURNAL,2024年19(2):e202300860- ISSN：1861-4728
通讯作者：
Liu, SH;Hartl, F
作者机构：
[Yang, Xiao Fei; Liu, Sheng Hua; Liu, SH; Zhang, Ming-Xing] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Zhang, Ming-Xing] Hubei Univ Educ, Coll Chem & Life Sci, Hubei Key Lab Purificat & Applicat Plant Anticanc, Wuhan 430205, Peoples R China.;[Hartl, Frantisek; Hartl, F] Univ Reading, Dept Chem, Reading RG6 6DX, England.
通讯机构：
[Liu, SH ] C;[Hartl, F ] U;Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;Univ Reading, Dept Chem, Reading RG6 6DX, England.
摘要：
The reviewed literature documents that certain metallaaromatics with unconventional photophysical properties, redox and electronic transport properties and magnetism, have potential to be widely used in diverse practical applications, with selected examples of amino acid identification, photothermal effects, functional materials, photodynamic therapy (PDT) in biomedicine, single‐molecule junction conductors, and electron‐transport layer materials (ETLs) in solar cells. Abstract In recent years, the field of organometallic chemistry has made a great progress and diverse types of metallaaromatics have successively been reported. In those studies, incorporation of ligated osmium centers into metallaaromatic systems played a prominent role. The reviewed literature documents that certain metallaaromatics with unconventional photophysical properties, redox and electronic transport properties and magnetism, have potential to be widely used in diverse practical applications, with selected examples of amino acid and fluoride anion identification, photothermal effects, functional materials, photodynamic therapy (PDT) in biomedicine, single‐molecule junction conductors, and electron‐transport layer materials (ETLs) in solar cells.
关键词：
Compressible Navier-Stokes-Allen-Cahn system;Strong/classical solutions;Density-dependent viscosity;Large initial data
摘要：
This paper is concerned with a one-dimensional isentropic compressible Navier-Stokes-Allen-Cahn system with density-dependent viscosity, which models the motion of a mixture of two viscous compressible fluids. The case when the pressure $ p(\rho) = \rho^\gamma $, the viscosity $ \nu(\rho, \chi) = \rho^\alpha $, the interface thickness $ \delta(\rho) = \rho^\beta $ and the relaxation time function $ a(\rho, \chi, \chi_y) = \rho^\lambda $ is considered, where $ \rho $ and $ \chi $ are the density and the phase variable, respectively, and $ \gamma, \alpha, \beta, \lambda\in\mathbb{R} $ are parameters. Under some suitable assumptions on the parameters $ \gamma , \alpha, \beta, \lambda $ and the initial data, we prove the global existence and large-time behavior of nonvacuum strong and classical solutions to its Cauchy problem with large initial data. This appears to be the first global existence result on the Cauchy problem of the compressible Navier-Stokes-Allen-Cahn system with density-dependent viscosity and large data.
摘要：
Cancer cells need a greater supply of glucose mainly due to their aerobic glycolysis, known as the Warburg effect. Glucose transport by glucose transporter 1 (GLUT1) is the rate-limiting step for glucose uptake, making it a potential cancer therapeutic target. However, GLUT1 is widely expressed and performs crucial functions in a variety of cells, and its indiscriminate inhibition will cause serious side effects. In this study, we designed and synthesized a photocaged GLUT1 inhibitor WZB117-PPG to suppress the growth of cancer cells in a spatiotemporally controllable manner. WZB117-PPG exhibited remarkable photolysis efficiency and substantial cytotoxicity toward cancer cells under visible light illumination with minimal side effects, ensuring its safety as a potential cancer therapy. Furthermore, our quantitative proteomics data delineated a comprehensive portrait of responses in cancer cells under glucose deprivation, underlining the mechanism of cell death via necrosis rather than apoptosis. We reason that our study provides a potentially reliable cancer treatment strategy and can be used as a spatiotemporally controllable trigger for studying nutrient deprivation-related stress responses.
摘要：
The HIV-1 transactivator protein Tat interacts with the transactivation response element (TAR) at the three-nucleotide UCU bulge to facilitate the recruitment of transcription elongation factor-b (P-TEFb) and induce the transcription of the integrated proviral genome. Therefore, the Tat-TAR interaction, unique to the virus, is a promising target for developing antiviral therapeutics. Currently, there are no FDA-approved drugs against HIV-1 transcription, suggesting the need to develop novel inhibitors that specifically target HIV-1 transcription. We have identified potential candidates that effectively inhibit viral transcription in myeloid and T cells without apparent toxicity. Among these candidates, two molecules showed inhibition of viral protein expression. A molecular docking and simulation approach was used to determine the binding dynamics of these small molecules on TAR RNA in the presence of the P-TEFb complex, which was further validated by a biotinylated RNA pulldown assay. Furthermore, we examined the effect of these molecules on transcription factors, including the SWI/SNF complex (BAF or PBAF), which plays an important role in chromatin remodeling near the transcription start site and hence regulates virus transcription. The top candidates showed significant viral transcription inhibition in primary cells infected with HIV-1 (98.6). Collectively, our study identified potential transcription inhibitors that can potentially complement existing cART drugs to address the current therapeutic gap in current regimens. Additionally, shifting of the TAR RNA loop towards Cyclin T1 upon molecule binding during molecular simulation studies suggested that targeting the TAR loop and Tat-binding UCU bulge together should be an essential feature of TAR-binding molecules/inhibitors to achieve complete viral transcription inhibition.
摘要：
This paper focuses on the existence of positive solutions for the following weakly coupled Schrödinger system with supercritical growth except at the origin: $ \begin{equation*} \left\{ \begin{array}{ll} -\Delta u_1 = \mu_1|u_{1}|^{p(r) - 2}u_1 + \beta|u_{2}|^{\frac{p(r)}{2}}|u_1|^{\frac{p(r)}{2}-2}u_{1}, & x\in B_1(0), \\ -\Delta u_2 = \mu_2|u_{2}|^{p(r) - 2}u_{2} + \beta|u_{1}|^{\frac{p(r)}{2}}|u_2|^{\frac{p(r)}{2}-2}u_{2}, & x\in B_1(0), \end{array} \right. \end{equation*} $ where $ B_1(0) $ is an unit ball $ {\mathbb{R}^N} $ with $ N\ge 3 $, $ \beta\in\mathbb{R} $ is a coupling constant, $ \mu_1,\mu_2\in {\mathbb R} $ are constants, $ p(r) = 2^* + r^{\alpha} $ with $ 2^* = \frac{2N}{N-2} $. Assuming that $ 0<{\alpha}<\min\{\frac{N}{2},N-2\} $, we apply concentration-compactness idea to show that the problem has a positive solution provided that $ \beta>0 $ if $ N\ge 5 $ and $ \beta\in(0,\beta_0]\cup[\beta_1,+\infty) $ for some positive constants $ \beta_0<\beta_1 $ if $ N = 3,4 $.
摘要：
Visual Dialog aims to answer an appropriate response based on a multi-round dialog history and a given image. Existing methods either focus on semantic interaction, or implicitly capture coarse-grained structural interaction (e.g., pronoun co-references). The fine-grained and explicit structural interaction feature for dialog history is seldom explored, resulting in insufficient feature learning and difficulty in capturing precise context. To address these issues, we propose a structure-aware dual-level graph interactive network (SDGIN) that integrates verb-specific semantic roles and co-reference resolution to explicitly capture context structural features for discriminative and generative tasks in visual dialog. Specifically, we create a novel structural interaction graph that injects syntactic knowledge priors into dialog by introducing semantic role labeling that imply which words are sentence stems. Furthermore, considering the single perspective limitation of previous algorithms, we design a dual-perspective mechanism that learns fine-grained token-level context structure features and coarse-grained utterance-level interactions in parallel. It possess an elegant view to explore precise context interactions, realizing the mutual complementation and enhancement of different granularity features. Experimental results show the superiority of our proposed approach. Compared to other task-specific models, our SDGIN outperforms previous models and achieves a significant improvement on the benchmark dataset VisDial v1.0.
摘要：
Eukaryotic DNA is packaged into chromatin in the nucleus, restricting the binding of transcription factors (TFs) to their target DNA sites. FOXA1 functions as a pioneer TF to bind condensed chromatin and initiate the opening of local chromatin for gene expression. However, the principles of FOXA1 recruitment and how it subsequently unpacks the condensed chromatin remain elusive. Here, we revealed that FOXA1 intrinsically forms submicron-sized condensates through its N- and C-terminal intrinsically disordered regions (IDRs). Notably, both IDRs enable FOXA1 to dissolve the condensed chromatin. In addition, the DNA-binding capacity of FOXA1 contributes to its ability to both form condensates and dissolve condensed chromatin. Further genome-wide investigation showed that IDRs enable FOXA1 to bind and unpack the condensed chromatin to regulate the proliferation and migration of breast cancer cells. This work provides a principle of how pioneer TFs function to initiate competent chromatin states using their IDRs.
作者机构：
[Chang, CH; Ho, Chia-An; Chang, Chun-Hao; Yeh, Hung-Chih; Chen, Chao-Yuan; Ho, Chin-Shan] Natl Taiwan Sport Univ, Grad Inst Sports Sci, Taoyuan City, Taiwan.;[Li, Fang] Cent China Normal Univ, Sch Phys Educ, Wuhan, Hubei, Peoples R China.;[Chen, Chao-Yuan] Natl Taipei Univ Business, Sport Off, Taipei City, Taiwan.
通讯机构：
[Chang, CH ] N;Natl Taiwan Sport Univ, Grad Inst Sports Sci, Taoyuan City, Taiwan.
关键词：
Mechanical property;Myometer;Rowing;Symmetry index
摘要：
BACKGROUND: The mechanical properties of muscles, such as changes in muscle tone and stiffness, are related to sports performance and injuries. Rowers are at increased risk of muscle fatigue and injury during high-repetition and heavy-load cyclic muscle actions. In view of this, the aim of the present study was to investigate the acute effect on muscle tone and stiffness, as well as bilateral muscle asymmetry, in high school rowers after a 2000-meter rowing ergometer test. METHODS: Twelve young male rowers (age = 17.1 ± 0.9 years, body weight = 73.5 ± 9.7 kg) were included in the study. The data of muscle tone (frequency) and stiffness of the posterior deltoids (PD), latissimus dorsi (LD), and rectus femoris (RF) (dominant and non-dominant side) before and after a 2000-m rowing ergometer test were collected using a handheld MyotonPRO device. RESULTS: After the rowing ergometer test, the muscle tone of dominant side PD, LD, and RF were significantly increased (p < 0.05). On the other hand, the muscle stiffness of the non-dominant side LD and RF, as well as the dominant side PD, LD, and RF were significantly increased after the rowing ergometer test (p < 0.05). The muscle tone and stiffness results showed that the dominant side PD, LD, and RF were all significantly higher than the non-dominant side after the rowing ergometer test (p < 0.05), where bilateral PD and RF exhibits moderate asymmetry (5% < symmetry index < 10%). CONCLUSIONS: After a high-intensity and high-load 2000-m rowing ergometer test, PD, LD, and RF showed increases in muscle tone and stiffness, as well as changes in the symmetry of bilateral muscle mechanical properties.
期刊：
Journal of Organizational and End User Computing,2024年36(1) ISSN：1546-2234
通讯作者：
Peng, Y
作者机构：
[Xiong, Li; Chen, Yuanyuan] Cent China Normal Univ, Wuhan, Peoples R China.;[Peng, Y; Xiong, Li; Peng, Yi] Yangtze Univ, Jingzhou, Peoples R China.;[Ghadi, Yazeed Yasin] Al Ain Univ, Al Ain, U Arab Emirates.
通讯机构：
[Peng, Y ] Y;Yangtze Univ, Jingzhou, Peoples R China.
摘要：
This study aims to enhance the efficacy of personalized learning paths by amalgamating transformer models, generative adversarial networks (GANs), and reinforcement learning techniques. To refine personalized learning trajectories, the authors integrated the transformer model for enhanced information assimilation and learning path planning. Through generative adversarial networks, the authors simulated the fusion and interaction of multi-modal information, refining the training of virtual teaching assistants. Lastly, reinforcement learning was employed to optimize the interaction strategies of these assistants, aligning them better with student needs. In the experimental phase, the authors benchmarked their approach against six state-of-the-art models to assess its effectiveness. The experimental outcomes highlight significant enhancements achieved by the authors' virtual teaching assistant compared to traditional methods. Precision improved to 95% and recall to 96%, and an F1 score exceeding 95% was attained.
期刊：
Journal of Inverse and Ill-posed Problems,2024年 ISSN：0928-0219
通讯作者：
Xiang, JL
作者机构：
[Xiang, Jianli; Xiang, JL] China Three Gorges Univ, Coll Sci, Three Gorges Math Res Ctr, Yichang 443002, Peoples R China.;[Yan, Guozheng] Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Peoples R China.;[Yan, Guozheng] Hubei Key Lab Math Phys, Wuhan, Peoples R China.
通讯机构：
[Xiang, JL ] C;China Three Gorges Univ, Coll Sci, Three Gorges Math Res Ctr, Yichang 443002, Peoples R China.
关键词：
Modified linear sampling method;variational method;interior transmission problem;partially coated dielectric
摘要：
Consider time-harmonic electromagnetic wave scattering by an infinitely long, cylindrical, orthotropic dielectric partially coated with a very thin layer of a highly conductive material, which can be modeled by a transmission problem with mixed boundary conditions. Having established the well-posedness of the direct and interior transmission problem by the variational method under certain conditions, we make use of the classical linear sampling method to reconstruct the shape of the obstacle. Then, based on a modification of the general data-to-pattern operator G, we propose a novel and simple method to justify the modified linear sampling method.
摘要：
Entities and relations extraction are the key tasks in the construction of biomedical knowledge graph, which play an important role in the biomedical artificial intelligence. However, extraction of entities and relations from biomedical texts is challenging because of the overlapping triples problem. The previous approaches typically divided the task into two separate sub-tasks. However, these methods failed to address the error propagation problem. Recent methods have been proposed to perform both sub-tasks simultaneously. Nonetheless, most current methods still encounter issues related to imbalanced interactions and independent features. In this paper, we propose a novel method based on feature partition encoding and relative positional embedding to joint extract biomedical entity and relation triples simultaneously. Compared to previous work, our method shows exceptional accurate in extracting entities and relations, while efficiently tackling the challenge of overlapping triples in biomedical texts. Our work has two contributions. Firstly, our method divides the features into task-specific and shared parts through entity, relation and sharing partitions at the encoding stage. And the encoded features will be aggregated according to the subsequent tasks. Secondly, we introduce a relative positional embedding method to capture the relative distance information between token pairs. In this way, our method can effectively deal with the sub-tasks interactions problem and improve entities and relations extraction. The experimental results show that our method improves the F1 scores of relations extraction by 3.2%, 2.1%, 3.4%, and 2.8% on four biomedical datasets, respectively.
作者机构：
[Guan, Rui; Sun, Yao; Li, Junrong; Liu, Guorong] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Yan, Mingzhe] Huazhong Univ Sci & Technol, Wuhan Jinyintan Hosp, Tongji Med Coll, Wuhan 430023, Peoples R China.;[Cheng, Jing] Wuhan Univ Sci & Technol, Sch Publ Hlth, Wuhan 430072, Peoples R China.;[Zhan, Jianbo] Hubei Prov Ctr Dis Control & Prevent, Inst Hlth Inspect & Testing, Wuhan 430072, Peoples R China.;[Wuethrich, Alain; Trau, Matt; Wuethrich, A] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Ctr Personalized Nanomed, Brisbane, Qld 4072, Australia.
通讯机构：
[Wuethrich, A ] U;[Sun, Y ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;Univ Queensland, Australian Inst Bioengn & Nanotechnol, Ctr Personalized Nanomed, Brisbane, Qld 4072, Australia.
摘要：
The molecular detection of multiple respiratory viruses provides evidence for the rational use of drugs and effective health management. Herein, we developed and tested the clinical performance of an electrohydrodynamic-driven nanobox-on-mirror platform (E-NoM) for the parallel, accurate, and sensitive detection of four respiratory viral antigens. The E-NoM platform uses gold-silver alloy nanoboxes as the core material with the deposition of a silver layer as a shell on the core surfaces to amplify and enable a reproducible Raman signal readout that facilitates accurate detection. Additionally, the E-NoM platform employs gold microelectrode arrays as the mirror with electrohydrodynamics to manipulate the fluid flow and enhance molecular interactions for an improved biosensing response. The presence of viral antigens binds the nanobox-based core-shell nanostructure on the gold microelectrode and creates the nanocavity with extremely strong "hot spots" to benefit sensitive analysis. Significantly, in a large clinical cohort with 227 patients, the designed E-NoM platform demonstrates the capability of screening respiratory infection with achieved clinical specificity, sensitivity, and accuracy of 100.0, 96.48, and 96.91%, respectively. It is anticipated that the E-NoM platform can find a position in clinical usage for respiratory disease diagnosis.
作者机构：
[Li, Qian; Yan, Qiang; Yan, Q; Li, Yuntao] Zhejiang Univ, Huzhou Cent Hosp, Affiliated Huzhou Hosp, Dept Gen Surg,Sch Med, Huzhou 313000, Peoples R China.;[Li, Qian; Sun, Yao; Zhao, Fang] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Ye, Huan] Guangxi Univ, Sch Light Ind & Food Engn, Nanning 530004, Peoples R China.;[Zhang, ZP; Zhang, Zhipeng] Hubei Univ Sci & Technol, Xianning Med Coll, Coll Pharm, Xianning 437100, Peoples R China.
通讯机构：
[Zhang, ZP ] H;[Sun, Y ] C;[Yan, Q ] Z;Zhejiang Univ, Huzhou Cent Hosp, Affiliated Huzhou Hosp, Dept Gen Surg,Sch Med, Huzhou 313000, Peoples R China.;Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
摘要：
Bacterial infections can lead to the development of large-scale outbreaks of diseases that pose a serious threat to human life and health. Also, conventional antibiotics are prone to producing resistance and allergic reactions, and their therapeutic effect is dramatically diminished when bacterial communities form biofilms. Fortunately, well-designed supramolecular coordination complexes (SCCs) have been used as antibacterials or anti-biofilms in recent years. SCCs can kill bacteria by directly engaging with the bacterial surface through electrostatic interactions or by penetrating the bacterial membrane through the auxiliary effect of cell-penetrating peptides. Furthermore, scientists have engineered fluorescent SCCs that can produce reactive oxygen species (ROS) to eliminate bacteria when exposed to laser irradiation, and they also demonstrate outstanding performance in in vivo imaging, enabling integrated diagnosis and treatment. In this review, we summarize the design strategy and applications of SCCs in antibacterials or anti-biofilms and provide an outlook on future research.
作者机构：
[Chen, Jingying; Wang, Zhun; Xu, Ruyi; Zhou, Longpu] Cent China Normal Univ, Fac Artificial Intelligence Educ, Wuhan 430079, Hubei, Peoples R China.;[Zhou, Longpu] Ningbo Yuxing Educ Technol Co Ltd, Ningbo, Zhejiang, Peoples R China.
通讯机构：
[Chen, JY ] C;Cent China Normal Univ, Fac Artificial Intelligence Educ, Wuhan 430079, Hubei, Peoples R China.
关键词：
Facial expression intensity estimation;Ordinal regression;Label distribution learning;Semi-supervised
摘要：
Facial expression intensity estimation has promising applications in health care and affective computing, such as monitoring patients’ pain feelings. However, labeling facial expression intensity is a specialized and time-consuming task. Ordinal regression (OR)-based methods address this issue to some extent by estimating the relative intensity but failing to estimate the absolute intensity due to lack of exploring useful information from noisy labels caused by manual and automatic labeling biases. Inspired by label distribution learning (LDL) to resist the noisy labels, this paper introduces the label-distribution-learning-enhanced OR (LDL-EOR) approach for facial expression intensity estimation. This design aims to utilize LDL to improve the accuracy of absolute intensity estimation while keeping the cost of manual labeling low. The label distribution is converted into a continuous intensity value by calculating the mathematical expectation, which makes the prediction results meet both relative and absolute intensity constraints. Ensuring the feasibility of LDL-EOR in different supervised settings, this paper presents a unified label distribution generation framework to automatically relabel training data frame by frame. The generated soft labels are used to supervise the LDL-EOR model and enhance its robustness to the noise existing in the original labels. Numerous experiments were conducted on three public expression datasets (CK+, BU-4DFE, and PAIN) to validate the superiority of LDL-EOR relative to other state-of-the-art approaches.
作者机构：
[Zhang, Yang; Zhang, Y] Shanghai Polytech Univ, Sch Econ & Management, Shanghai 201209, Peoples R China.;[Wang, Xuechun] Hubei Univ Technol, Sch Elect & Elect Engn, Wuhan 430068, Peoples R China.;[Wen, Jinghao] Cent China Normal Univ, Sch Comp Sci, Wuhan 430079, Peoples R China.;[Zhu, Xianxun] Shanghai Univ, Sch Commun & Informat Engn, Shanghai 200444, Peoples R China.
通讯机构：
[Zhang, Y ] S;Shanghai Polytech Univ, Sch Econ & Management, Shanghai 201209, Peoples R China.
关键词：
Human presence sensing;Machine learning;Non-contact;Wireless perception
摘要：
In the swiftly evolving landscape of Internet of Things (IoT) technology, the demand for adaptive non-contact sensing has seen a considerable surge. Traditional human perception technologies, such as vision-based approaches, often grapple with problems including lack of sensor versatility and sub-optimal accuracy. To address these issues, this paper introduces a novel, non-contact method for human presence perception, relying on WiFi. This innovative approach involves a sequential process, beginning with the pre-processing of collected Channel State Information (CSI), followed by feature extraction, and finally, classification. By establishing signal models that correspond to varying states, this method enables the accurate perception and recognition of human presence. Remarkably, this technique exhibits a high level of precision, with sensing accuracy reaching up to 99%\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\%$$\end{document}. The potential applications of this approach are extensive, proving to be particularly beneficial in contexts such as smart homes and healthcare, amongst various other everyday scenarios. This underscores the significant role this novel method could play in enhancing the sophistication and effectiveness of human presence detection and recognition systems in the IoT era.
