作者机构：
Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.;Chinese Acad Sci, Grad Sch, Beijing 10093, Peoples R China.;[Liu, JT] Chinese Acad Sci, Inst Hydrobiol, 7 S Rd Donghu Lake, Wuhan 430072, Peoples R China.
通讯机构：
[Liu, JT] C;Chinese Acad Sci, Inst Hydrobiol, 7 S Rd Donghu Lake, Wuhan 430072, Peoples R China.
期刊：
INDOOR AIR 2005: PROCEEDINGS OF THE 10TH INTERNATIONAL CONFERENCE ON INDOOR AIR QUALITY AND CLIMATE, VOLS 1-5,2005年15:3556-3559 ISSN：0908-5920
通讯作者：
Li, R
作者机构：
[Chen, WG; Wei, F; Peng, JS; Wu, L; Hu, JC; Zhou, X; Q Z; Yao, DS; Liu, MQ; Yang, X; Li, R] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
通讯机构：
[Li, R] C;Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
会议名称：
10th International Conference on Indoor Air Quality and Climate (Indoor Air 2005)
会议时间：
SEP 04-09, 2005
会议地点：
Beijing, PEOPLES R CHINA
会议主办单位：
Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
关键词：
formaldehyde;genotoxicity;comet assay;buccal cell;epidemiological study
摘要：
In this study, 60 families in the same community were investigated. Amnong these families, 30 were decorated within one year while the corresponding ones decorated at least 4 years ago. Buccal cells donated by people available in these families were employed to carry out single cell gel electrophoresis (SCGE, Comet assay, for genotoxicity testing). Analysis of the comet images showed that the presenting rate of "comet" as well as the tail moments of the buccal cells' DNA from people living in apartments decorated within a year were obviously higher (P < 0.01) than in those from people who lived in the apartments decorated several years ago, which lends strong support to our conclusion that people living in newly-decorated apartments are much more liable to be harmed by the formaldehyde released from their indoor decoration. In addition, high-quality decoration material tends to be less harmful to people.
摘要：
To explore protein oxidative damage induced by gaseous formaldehyde and its mechanism we carried out this study. Mice were treated with gaseous formaldehyde at different levels (0 mg.m(-3) 0.68 mg.m(-3) and 3.0 mg.m(-3)) for 72 hr and the protein carbonyl content was mensurated using spectrophotometric DNPH assay to reflect the degree of protein oxidative damage. The results show that the protein carbonyl content of brain, heart and liver tissue in mice decrease in the group of 0.68 mg.m(-3) (p < 0.01, p < 0.01, p < 0.05), while increase significantly in heart and liver tissue in the group of 3.0 mg.m(-3) (P < 0.01, P < 0.01) and protein carbonyl content in brain does not have notable difference compared with the control (p > 0.05). These results indicate that the protein oxidative damage induced by gaseous formaldehyde depends on the concentration of gaseous formaldehyde. Medium concentration formaldehyde may not induce protein oxidative damage, while high concentration formaldehyde can cause protein oxidative damage in heart and liver tissue markedly and has little effect on protein of brain.
作者机构：
[Li, WP] Hunan Normal Univ, Coll Life Sci, Changsha 410081, Peoples R China.;Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
通讯机构：
[Li, WP] H;Hunan Normal Univ, Coll Life Sci, Changsha 410081, Peoples R China.
关键词：
狭叶三脉紫菀;小花三脉紫菀;神农架;形态学;染色体
摘要：
产自湖北神农架的狭叶三脉紫菀Aster ageratoides var. gerlachii (Hance) Chang一直被各种文献和有关标本馆误定为小花三脉紫菀A. ageratoides var. micranthus Ling.我们对二者进行了野外采集和形态学、细胞学的比较研究,分析了导致错误鉴定的原因,重新确定了二者的界限.小花三脉紫菀无横走地下茎,这一性状具有重要的分类学价值.核型研究发现,小花三脉紫菀为二倍体,2n=2x=18=18m,核型属1A型;狭叶三脉紫菀则是四倍体,2n=4x=36=32m+4sm (2SAT),核型属2A型.二变种的染色体数目、核型均为首次报道.狭叶三脉紫菀在湖北为新分布记录.
作者：
Wang Dan;Pi Jianhui;Tan Jia;Tang Jia;Wu Feijian;...
期刊：
生理学报,2005年57(1):59-65 ISSN：0371-0874
通讯作者：
Wang, D.
作者机构：
[Wang Dan; Tang Jia; Tan Jia; Wu Feijian; Chen Qicai] School of Life Sciences, Central China Normal University;[Pi Jianhui] Department of Biology, Huaihua College of Hunan
摘要：
In order to explore the possible mechanisms by which ethologically relevant sounds can be extracted from complex auditory environments, this study examined the effects of weak noise on the rate-intensity functions (RIFs) of neurons responding to tone burst in the inferior colliculus (IC) of nine mice (Mus musculus Km). Under free field stimuli conditions, a total of 112 IC neurons were recorded. RIFs with and without simultaneous presentation of weak noise, of which the intensity was relative to 5 dB below minimum threshold of tone burst, were measured in 44 IC neurons. By means of evaluating the changes of dynamic range (DR), slope of RIFs, and percent inhibition at different tone burst intensities evoked by the weak noise, three types of variations in RIFs were observed, i. e.,inhibition (39/44, 88.6%), facilitation (2/44, 4.6%), and no effectiveness (3/44, 6.8%). Statistical analysis indicated that only inhibitory effect of weak noise was significant (P ＜ 0.001, n = 39). The inhibitory effect of weak noise was greater at lower stimulus intensity of tone burst but decreased significantly with increased stimulus intensity (P ＜ 0.0001, n = 39). In addition, the DR and slope of RIFs became narrower and steeper with weak noise presentation, respectively (P ＜ 0.01, n = 31). The results from the present study suggest that weak noise exerts a dynamic modulatory action on acoustical intensity sensitivity of IC neurons, which possibly leads to a better understanding of neural mechanisms underlying the extraction of sound signals from natural auditory scenes.
作者：
Philip H.S.Jen;LUAN Rui-Hong;WU Fei-Jian;SUN Xin-de
期刊：
生理学报,2005年57(2):225-232 ISSN：0371-0874
通讯作者：
Luan, R.H.
作者机构：
[LUAN Rui-Hong; SUN Xin-de] College of Life Sciences,East China Normal University;[WU Fei-Jian] College of Life Sciences,Central China Normal University;[Philip H.S.Jen] Division of Biological Sciences,University of Missouri-Columbia
摘要：
Temporal features of sound convey information vital for behaviors as diverse as speech recognition by human and echolocation by bats. However, auditory stimuli presented in temporal proximity might interfere with each other. Although much progress has been made in the description of this phenomenon from psychophysical studies, the neural mechanism responsible for its formation at central auditory structures especially at the inferior colliculus (IC), a midbrain auditory nucleus which practically receives massive bilateral projections from all the major auditory structures in the brainstem, remains unclear. This study was designed to investigate it in vivo by using electrophysiological recording from the inferior collicular neurons of the big brown bat, Eptesicus fuscus. In our results, the responses of 12 (38%, n= 31) neurons to the test sound (leading sound) were obviously inhibited by the masker (lagging sound). The inhibitory effects in these neurons were correlated with the inter-stimulus level difference (SLD) and the inter-stimulus onset asynchrony (SOA) interval. The strength of backward masking increased with the masker intensity increasing, the test sound intensity decreasing and the SOA interval shortening. There were no obvious effects of backward masking on the responses of many other neurons (52%, 16/31), and yet in a part of these neurons, the neural inhibition of responses to the test sound was observed at the special SLD and the special SOA intervals. Moreover, few of the 31 sampled IC neurons (10%, 3/31) displayed facilitating responses to the test sound at the special SLD and the special SOA intervals. These data demonstrate that a lot of IC neurons are involved in the generation of the backward masking of acoustical perception. It is conjectured that the temporal dynamic integration between the leading inhibitory inputs evoked by the masker sound and the excitatory inputs evoked by the test sound might play a key role in shaping the acoustical response characteristics of the IC neurons.
期刊：
INDOOR AIR 2005: PROCEEDINGS OF THE 10TH INTERNATIONAL CONFERENCE ON INDOOR AIR QUALITY AND CLIMATE, VOLS 1-5,2005年:3831-3835
通讯作者：
Yang, X
作者机构：
[Qiao, Y; Liu, Y; Duan, L; Yan, Y; Lu, Z; Cao, Y; Yang, X] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
通讯机构：
[Yang, X] C;Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
会议名称：
第十届室内空气品质和质量国际学术会议(Proceedings of the 10th International Conference on Indoor Air Quality and Climate)
会议时间：
2005-09-04
会议地点：
北京
会议论文集名称：
第十届室内空气品质和质量国际学术会议
关键词：
Formaldehyde;Toxicological study;Physiological study
摘要：
This paper is a review on recent developments of the toxicological and physiological studies on formaldehyde. Hotspots involved in this topic include: (1) Formaldehyde-induced gene expression; (2) Formaldehyde-induced asthma; (3) Airway neurogenic inflammation (4) formaldehyde working as signaling molecule in body; (5) Epigenesis: methylation of DNA and proteins; (6) DNA-protein crosslink; (7) Lysine-DPC repair enzyme; (8) Formaldehyde-induced Apoptosis.
