摘要：
The HIV-1 transactivator protein Tat interacts with the transactivation response element (TAR) at the three-nucleotide UCU bulge to facilitate the recruitment of transcription elongation factor-b (P-TEFb) and induce the transcription of the integrated proviral genome. Therefore, the Tat-TAR interaction, unique to the virus, is a promising target for developing antiviral therapeutics. Currently, there are no FDA-approved drugs against HIV-1 transcription, suggesting the need to develop novel inhibitors that specifically target HIV-1 transcription. We have identified potential candidates that effectively inhibit viral transcription in myeloid and T cells without apparent toxicity. Among these candidates, two molecules showed inhibition of viral protein expression. A molecular docking and simulation approach was used to determine the binding dynamics of these small molecules on TAR RNA in the presence of the P-TEFb complex, which was further validated by a biotinylated RNA pulldown assay. Furthermore, we examined the effect of these molecules on transcription factors, including the SWI/SNF complex (BAF or PBAF), which plays an important role in chromatin remodeling near the transcription start site and hence regulates virus transcription. The top candidates showed significant viral transcription inhibition in primary cells infected with HIV-1 (98.6). Collectively, our study identified potential transcription inhibitors that can potentially complement existing cART drugs to address the current therapeutic gap in current regimens. Additionally, shifting of the TAR RNA loop towards Cyclin T1 upon molecule binding during molecular simulation studies suggested that targeting the TAR loop and Tat-binding UCU bulge together should be an essential feature of TAR-binding molecules/inhibitors to achieve complete viral transcription inhibition.
摘要：
Divergent thinking is assumed to benefit from releasing the constraint of existing knowledge (i.e. top-down control) and enriching free association (i.e. bottom-up processing). However, whether functional antagonism between top-down control-related and bottom-up processing-related brain structures is conducive to generating original ideas is largely unknown. This study was designed to investigate the effect of functional antagonism between the left inferior frontal gyrus and the right temporoparietal junction on divergent thinking performance. A within-subjects design was adopted for three experiments. A total of 114 participants performed divergent thinking tasks after receiving transcranial direct current stimulation over target regions. In particular, cathodal stimulation over the left inferior frontal gyrus and anodal stimulation over the right inferior frontal gyrus (Experiment 1), anodal stimulation over the right temporoparietal junction (Experiment 2), and both cathodal stimulation over the left inferior frontal gyrus and anodal stimulation over the right temporoparietal junction (Experiment 3) were manipulated. Compared with sham stimulation, the combination of hyperpolarization of the left inferior frontal gyrus and depolarization of the right temporoparietal junction comprehensively promoted the fluency, flexibility, and originality of divergent thinking without decreasing the rationality of generated ideas. Functional antagonism between the left inferior frontal gyrus (hyperpolarization) and right temporoparietal junction (depolarization) has a "1 + 1 > 2" superposition effect on divergent thinking.
摘要：
The current study developed a moderated mediation model to investigate the effects of parental perfectionist expectations on online gaming addiction and its underlying mechanisms among Chinese undergraduates. 6403 Chinese undergraduates from Guangxi and Sichuan (51.0% males, mean age = 19.17 years) consented to take part in the study. The findings revealed that trait anxiety and perceived stress significantly mediated the relationship between parental perfectionist expectations and online gaming addiction. Moreover, flow experience moderated the effects of parental perfectionist expectations and trait anxiety on online gaming addiction, and this relationship was stronger with higher flow experience. These findings underscore the importance of a relatively comprehensive approach that takes into account both parental and individual factors when designing prevention and intervention strategies for online gaming addiction.
作者机构：
[Zha, S; Zha, Shuai] Hubei Univ Chinese Med, Sch Lab Med, 16 Huangjia Lake West Rd, Wuhan 430065, Peoples R China.;[Zha, S; Zha, Shuai] Hubei Shizhen Lab, Wuhan 430061, Peoples R China.;[Jian, Yuehan; Pan, Siyu; Jiang, Lijun] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.;[Peng, Yunhui] Cent China Normal Univ, Inst Biophys, Dept Phys, Wuhan 430079, Peoples R China.
通讯机构：
[Zha, S ] H;[Jiang, LJ ] C;Hubei Univ Chinese Med, Sch Lab Med, 16 Huangjia Lake West Rd, Wuhan 430065, Peoples R China.;Hubei Shizhen Lab, Wuhan 430061, Peoples R China.;Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
关键词：
Lanthanide nanosensor;Upconversion emission;NIR-II fluorescence;H 2 S detection;Endogenous H 2 S activated nanosensor
摘要：
Hydrogen sulfide (H2S), a third gas signaling molecule, is considered to play a vital role in the development and treatment of diseases. To elucidate the intricate role of H2S in the organism and its participation in disease processes, there is an urgent need to visualize the dynamics of H2S. However, most currently available molecular probes have limitations in terms of sensitivity, specificity, and precision. In this study, the safe and biocompatible upconversion nanosensor NaYF4:Yb3+, Tm3+@NaYF4 anchored with Ag2O was successfully fabricated for H2S detection with an ultralow detection limit at 0.93 ng/mL. NaYF4:Yb3+, Tm3+@NaYF4@Ag2S is formed through in situ sulfuration reaction, and second near-infrared (NIR-II) fluorescence can be recorded upon the presence of H2S under 808 nm excitation. The results demonstrate the exceptional detection linearity and high specificity for H2S quantification. Additionally, NaYF4:Yb3+, Tm3+@NaYF4@Ag2O possesses a safe nature in normal and cancer cells. This nanosensor presents a NIR fluorescence imaging strategy for highly sensitive and specific detection of H2S, which has promises to be a practical tool for biomedical applications.
期刊：
FRONTIERS IN PSYCHIATRY,2024年14:1298380 ISSN：1664-0640
通讯作者：
Zhang, W
作者机构：
[Zhang, Wei; Li, Ziyi; Xue, Jinfeng] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Liu, Li; Xue, Jinfeng] Hunan Univ Chinese Med, Sch Nursing, Changsha, Peoples R China.;[Zhang, Wei] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan, Peoples R China.;[Li, Wendi] Xiamen Hubin High Sch, Xiamen, Peoples R China.;[Zhang, Zhiyou] Hunan Coll Informat, Sch Mechatron Engn, Changsha, Peoples R China.
通讯机构：
[Zhang, W ] C;Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan, Peoples R China.
关键词：
college students;internet addiction;longitudinal study;reinforcement sensitivity;self-control
摘要：
INTRODUCTION: As the rapid expanding of internet technology, it is necessary to pay attention to the factors that predict Internet addiction. This study aimed to investigate the longitudinal impact of reinforcement sensitivity on internet addiction among college students and the mediating role of self-control. METHODS: The study involves two follow-up assessments with a 5-month interval. 383 college students' reinforcement sensitivity, self-control, and internet addiction were measured at two-time points. RESULTS: ①The revised Behavioral Approach System (r-BAS) at Time Point 1 (T1) could predict both T1 and Time Point 2 (T2) internet addiction through the complete mediation of T1 self-control. ②The revised Behavioral Inhibition System (r-BIS) at T1, along with the Fight/Flight/Freeze System (FFFS), can predict T1 and T2 internet addiction through the partial mediation of T1 self-control. CONCLUSION: Reinforcement sensitivity can predict current and future internet addiction, with self-control playing a mediating role. This study provides longitudinal experimental evidence for the revised Reinforcement Sensitivity Theory (r-RST), further revealing the underlying mechanisms through which reinforcement sensitivity influences internet addiction. Additionally, it has implications for clinical intervention.
作者机构：
[Li, Weina] Hunan Police Acad, Dept Management, Changsha 410138, Peoples R China.;[Song, Youzhi; Zhou, Zongkui; Gu, Chuanhua; Li, Weina] Cent China Normal Univ, Key Lab Adolescent Cyberpsychol & Behav, Minist Educ, Wuhan 430079, Peoples R China.;[Song, Youzhi; Zhou, Zongkui; Gu, Chuanhua; Li, Weina] Cent China Normal Univ, Sch Psychol, Wuhan 430079, Peoples R China.;[Wang, Baiheng] Univ Georgia, Dept Psychol, Athens, GA 30602 USA.
通讯机构：
[Zhou, ZK ] C;Cent China Normal Univ, Key Lab Adolescent Cyberpsychol & Behav, Minist Educ, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Sch Psychol, Wuhan 430079, Peoples R China.
关键词：
parents' responses to children's performance;subjective well-being;parent-child relationship;friendship quality
摘要：
The current study examined the psychological mechanism that underlies the relationship between parents' response style and children's subjective well-being and its boundary conditions, the mediating role of the parent-child relationship, and the moderating role of friendship quality. Using the Parents' Responses to Children's Performance Scale, the Buchanan Scale of Closeness to Parents, the Friendship Quality Questionnaire, and the Campbell Index of Well-being, our study investigated 686 pupils who were randomly selected from three public schools in central China. Employing Mplus 8.3 for pathway analysis, we found the following results: Failure-oriented responses negatively predict children's subjective well-being (beta = -0.16, p < 0.001), while success-oriented responses positively predict children's subjective well-being (beta = 0.13, p < 0.01). Both failure-oriented (ab = 0.18, SE = 0.03, 95% CI = [0.13, 0.25]) and success-oriented responses (ab = -0.10, SE = 0.02, 95% CI = [-0.14, -0.06]) predict children's subjective well-being through the mediating effect of the parent-child relationship. Friendship quality has a moderating effect on the mediating path (beta = -0.09, p < 0.05), such that when friendship quality is lower, the parent-child relationship has a higher mediating effect between the parents' responses and children's subjective well-being. This study offers empirical evidence that parents' responses to children's performance significantly contribute to children's subjective well-being. Moreover, it offers actionable insights for enhancing children's subjective well-being. The enhancement could be achieved by fostering positive parent-child relationships and enhancing the quality of children's friendships, thereby positively impacting their well-being.
作者：
Peng, Yunhui;Song, Wei;Teif, Vladimir B.;Ovcharenko, Ivan;Landsman, David;...
期刊：
ELIFE,2024年12 ISSN：2050-084X
通讯作者：
Peng, YH;Panchenko, AR
作者机构：
[Peng, Yunhui; Peng, YH] Cent China Normal Univ, Inst Biophys, Wuhan, Peoples R China.;[Peng, Yunhui; Peng, YH] Cent China Normal Univ, Dept Phys, Wuhan, Peoples R China.;[Ovcharenko, Ivan; Landsman, David; Peng, Yunhui; Peng, YH; Song, Wei] NIH, Natl Lib Med, Bethesda, MD 20892 USA.;[Teif, Vladimir B.] Univ Essex, Sch Life Sci, Wivenhoe Pk, Colchester, England.;[Panchenko, Anna R.; Panchenko, AR] Queens Univ, Dept Pathol & Mol Med, Kingston, ON, Canada.
通讯机构：
[Peng, YH ] C;[Panchenko, AR ] Q;Cent China Normal Univ, Inst Biophys, Wuhan, Peoples R China.;Cent China Normal Univ, Dept Phys, Wuhan, Peoples R China.;NIH, Natl Lib Med, Bethesda, MD 20892 USA.
摘要：
Wrapping of DNA into nucleosomes restricts accessibility to DNA and may affect the recognition of binding motifs by transcription factors. A certain class of transcription factors, the pioneer transcription factors, can specifically recognize their DNA binding sites on nucleosomes, initiate local chromatin opening, and facilitate the binding of co-factors in a cell-type-specific manner. For the majority of human pioneer transcription factors, the locations of their binding sites, mechanisms of binding, and regulation remain unknown. We have developed a computational method to predict the cell-type-specific ability of transcription factors to bind nucleosomes by integrating ChIP-seq, MNase-seq, and DNase-seq data with details of nucleosome structure. We have demonstrated the ability of our approach in discriminating pioneer from canonical transcription factors and predicted new potential pioneer transcription factors in H1, K562, HepG2, and HeLa-S3 cell lines. Last, we systematically analyzed the interaction modes between various pioneer transcription factors and detected several clusters of distinctive binding sites on nucleosomal DNA.
摘要：
BACKGROUND: Physical activity (PA) may prevent depressive symptoms, however, PA fluctuations may have different effects. Using three waves of nationally representative data, this study aimed to examine the effects of PA fluctuations on depressive symptoms. METHODS: Participants comprised 7633 adults free of depressive symptoms at the first two waves (M(age)=45.26, 54.70% males). They completed the China Family Panel Study in 2016 (T1), 2018 (T2), and 2020 (T3), respectively. Depressive symptoms were measured by the Center for Epidemiologic Studies Depression (CES-D) scale using a cutoff of 16. Participants' PA levels were split into regular PA or infrequent PA groups. Changes in PA levels between T1 and T2 were classified into four groups: maintained infrequent PA, initiated regular PA, ceased regular PA, and persisted regular PA. RESULTS: The incidence of depressive symptoms was 20.22% (19.05% possible and 1.17% severe depression). After multivariate adjustment, Poisson regression showed that persistent regular PA had 17.8% (95% CI: 0.724, 0.934) lower risks of incident depressive symptoms compared to maintained infrequent PA. And adults who ceased regular PA were more likely to experience depressive symptoms than those who persisted in regular PA (RR=1.188, 95% CI: 1.010, 1.398). LIMITATIONS: All items were self-reported. CES-D only examined self-diagnosed depressive symptoms, not medical diagnoses. CONCLUSION: Adults who persisted in regular PA may have a lower possibility of developing depressive symptoms. The finding might serve as an empirical reference to depression prevention.
期刊：
Building and Environment,2023年244:110800 ISSN：0360-1323
通讯作者：
Lu, C
作者机构：
[Lu, Chan; Lan, Mengju] Cent South Univ, XiangYa Sch Publ Hlth, Changsha, Peoples R China.;[Yang, Wenhui] Hunan Prov Maternal & Child Hlth Care Hosp, Changsha, Peoples R China.;[Li, Bin] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Wang, Faming] Katholieke Univ Leuven, Dept Biosyst, Div Anim & Human Hlth Engn, Leuven, Belgium.
通讯机构：
[Lu, C ] C;Cent South Univ, XiangYa Sch Publ Hlth, Changsha, Peoples R China.
关键词：
Childhood pneumonia;Pregnancy;Postnatal;Meteorological factors;Environmental temperature;Diurnal temperature variation
摘要：
Background: Childhood pneumonia remains a major public health concern worldwide, but the critical meteorological factors that contribute to it are unknown. Objective: To investigate the relationship between childhood pneumonia and prenatal and postnatal exposure to meteorological factors to identify the critical factors and vulnerable timing windows. Methods: We conducted a retrospective cohort study of 8689 preschoolers in China. We gathered information on personal factors, health status, and indoor environment through questionnaires. We considered meteorological factors including temperature (mean, maximum, minimum), diurnal temperature variation (DTV), relative humidity, wind speed, rainfall, pressure and sunshine during early life. Using multiple logistic regression models, we investigated the links between childhood pneumonia and early life exposure to meteorological factors. Results: Exposure to mean, maximum, and minimum temperatures was associated with childhood pneumonia in the first month and first trimester, with ORs (95% CI) of 1.32 (1.07-1.62), 1.26 (1.04-1.52) and 1.33 (1.08-1.64) in the first month, and 1.42 (1.12-1.81), 1.36 (1.08-1.71) and 1.47 (1.15-1.88) in the first trimester for per IQR increase in each meteorological factor exposure. Wind speed, rainfall, and sunshine exhibited significant associations with pneumonia during the first, second, and third trimesters, respectively. Exposure to various temperatures, DTV, relative humidity, rainfall, air pressure, and sunshine were linked to childhood pneumonia in the postnatal period, particularly in the previous year. The sensitivity analysis revealed that boys are more vulnerable to meteorological factors. Keeping dogs or plants may offer protection against the pneumonia risk of prenatal and postnatal meteorological exposure. Conclusion: Exposure to meteorological factors during both the prenatal and postnatal periods, especially in early pregnancy, was found to elevate the risk of childhood pneumonia.
期刊：
Journal of Affective Disorders,2023年323:444-451 ISSN：0165-0327
通讯作者：
Zhihong Ren
作者机构：
[Ren, Zhihong; Tong, Jingqiang; Zhang, Lin; Lai, Lizu] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Ren, Zhihong; Tong, Jingqiang; Zhang, Lin; Lai, Lizu] Minist Educ, Key Lab Adolescent CyberPsychol & Behav CCNU, Wuhan, Peoples R China.;[Xiang, Yu-Tao] Univ Macau, Inst Translat Med, Fac Hlth Sci, Unit Psychiat, Macau, Peoples R China.;[Xiang, Yu-Tao] Univ Macau, Ctr Cognit & Brain Sci, Macau, Peoples R China.;[Ren, Zhihong; Tong, Jingqiang; Zhang, Lin; Lai, Lizu] Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan, Peoples R China.
通讯机构：
[Zhihong Ren] S;School of Psychology, Central China Normal University, China<&wdkj&>Key Laboratory of Adolescent CyberPsychology and Behavior(CCNU), Ministry of Education, Wuhan, China<&wdkj&>Key Laboratory of Human Development and Mental Health of Hubei Province, China
摘要：
BACKGROUND: The present study aimed to investigate the pandemic stage differences of mental health helpline help-seekers emotional responses, psychiatric symptoms, and related network structures during the COVID-19 pandemic in China. METHODS: The data was collected by a large-scale psychological helpline in response to the COVID-19 pandemic in mainland China. Counselor-reported information about the help-seekers pandemic-related emotional responses and psychiatric symptoms were recorded. A total of 26,870 callers' data from February 28, 2020, to April 23, 2021, were collected in the present study. A linear probability model and network analysis were conducted to determine the differences in help-seekers mental health concerns and network structures between the pandemic (stage I, from February 28, 2020, to April 28, 2020, N=9821) and the regular prevention and control period (stage II, from April 29, 2020, to April 23, 2021, N=17,049). RESULTS: Results revealed that anger, sadness, and obsession symptoms increased in stage II while symptoms of anxiety, somatization, and feelings of fear and stress were relieved. The network analysis results demonstrated both stage I and II networks centered on anxiety firmly. In stage II, the connection between anxiety and hypochondria and fear's strength centrality descended significantly. LIMITATIONS: The mental health outcomes of callers only included the counselor-reported data. CONCLUSIONS: The mental health concerns of helpline callers showed pandemic-related stage differences.
期刊：
FRONTIERS IN PSYCHIATRY,2023年14:1258673 ISSN：1664-0640
通讯作者：
Ye, JM;Zhao, X
作者机构：
[Wang, Weijun; Ye, Jianmei; Huang, Dawei] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan, Hubei, Peoples R China.;[Wang, Weijun; Ye, Jianmei; Zhu, Yimeng; Huang, Dawei] Cent China Normal Univ, Sch Psychol, Wuhan, Hubei, Peoples R China.;[Wang, Weijun] Wuhan Technol & Business Univ, Inst Digital Commerce, Wuhan, Peoples R China.;[Zhu, Yimeng] Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan, Peoples R China.;[Zhao, X; Zhao, Xin] Univ Sheffield, Informat Sch, Sheffield, England.
通讯机构：
[Zhao, X ] U;[Ye, JM ] M;Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan, Hubei, Peoples R China.;Cent China Normal Univ, Sch Psychol, Wuhan, Hubei, Peoples R China.;Univ Sheffield, Informat Sch, Sheffield, England.
关键词：
problematic internet use;Internet Self-Control;meaning in life;Cross-lagged panel model;Longitudinal mediation model;adolescents
摘要：
Introduction: While studies indicate that high self-control may serve as a safeguard against problematic internet use, there's evidence suggesting that problematic internet use can, in turn, diminish self-control. This study aimed to elucidate the longitudinal interplay between internet self-control and problematic internet use in adolescents, employing cross-lagged panel modeling. Furthermore, drawing from a positive psychology perspective, we examined the potential role of 'meaning in life' as a protective mediator within this longitudinal relationship. We then constructed a mediation model to explore protective factors against problematic internet use.Methods: Through a questionnaire, we tracked 659 adolescents (331 males and 328 females; mean age=13.61) in a longitudinal design across two time points, spaced at five-month intervals, to assess their internet self-control, problematic internet use, and meaning in life.Results: Results of the cross-lagged panel models showed that: Internet self-control had a significant negative impact on problematic internet use after five months (beta = -0.094, p < 0.01). Conversely, problematic internet use had a significant negative impact on internet self-control after five months (beta = -0.099, p < 0.05). Results from the longitudinal mediation model showed that: Meaning in life mediated the effect of internet self-control on problematic internet use after five months (beta(internet self-control(T1)-meaning in life(T2)) = 0.142, p < 0.01; beta(meaning in life(T1)-problematic internet use (T2)) = -0.075, p < 0.05).Conclusion: Our study uncovers a reciprocal predictive relationship between internet self-control and problematic internet use, while highlighting the mediating role of meaning in life within this relationship. These findings suggest that fostering internet self-control and cultivating a sense of meaning in life among adolescents can serve as effective prevention and intervention strategies for addressing the issue of problematic internet use.
作者机构：
[Li, Xu; Peng, Ming; Li, Qianqian; Chen, Tianlong] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Li, Xu; Peng, Ming] Cent China Normal Univ, Key Lab Adolescent Cyberpsychol & Behav, Minist Educ, Wuhan, Peoples R China.;[Peng, Ming] Cent China Normal Univ, Sch Psychol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Ming Peng] S;School of Psychology, Central China Normal University, Wuhan, China<&wdkj&>Key Laboratory of Adolescent Cyberpsychology and Behavior of the Ministry of Education and School of Psychology, Central China Normal University, Wuhan, China
摘要：
RNA regulates various biological processes, such as gene regulation, RNA splicing, and intracellular signal transduction. RNA's conformational dynamics play crucial roles in performing its diverse functions. Thus, it is essential to explore the flexibility characteristics of RNA, especially pocket flexibility. Here, we propose a computational approach, RPflex, to analyze pocket flexibility using the coarse-grained network model. We first clustered 3154 pockets into 297 groups by similarity calculation based on the coarse-grained lattice model. Then, we introduced the flexibility score to quantify the flexibility by global pocket features. The results show strong correlations between the flexibility scores and root-mean-square fluctuation (RMSF) values, with Pearson correlation coefficients of 0.60, 0.76, and 0.53 in Testing Sets I-III. Considering both flexibility score and network calculations, the Pearson correlation coefficient was increased to 0.71 in flexible pockets on Testing Set IV. The network calculations reveal that the long-range interaction changes contributed most to flexibility. In addition, the hydrogen bonds in the base-base interactions greatly stabilize the RNA structure, while backbone interactions determine RNA folding. The computational analysis of pocket flexibility could facilitate RNA engineering for biological or medical applications.
期刊：
Building and Environment,2023年245 ISSN：0360-1323
通讯作者：
Lu, C;Wang, FM
作者机构：
[Liu, Qin; Lu, Chan; Li, Qin; Liao, Hongsen; Wang, Lin] Cent South Univ, XiangYa Sch Publ Hlth, Changsha, Peoples R China.;[Li, Bin] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Wang, Faming; Wang, FM] Katholieke Univ Leuven, Dept Biosyst, Div Anim & Human Hlth Engn, Leuven, Belgium.
通讯机构：
[Wang, FM ] K;[Lu, C ] C;Cent South Univ, XiangYa Sch Publ Hlth, Changsha, Peoples R China.;Katholieke Univ Leuven, Dept Biosyst, Div Anim & Human Hlth Engn, Leuven, Belgium.
关键词：
Childhood asthma;Pregnancy;Early life exposure;Particulate matters;Accumulation effect
摘要：
Background: Despite mounting evidence linking asthma to air pollution, it remains unclear which specific pollutant(s) exposure during critical time window(s) plays a pivotal role in the development of asthma.Objective: The objective of this study is to investigate the effects of intrauterine and postnatal air pollution exposure on children's asthma.Methods: From 2019 to 2020, a retrospective cohort study was conducted in Changsha, China. The inverse distance weighted (IDW) method was used to estimate each child's personal exposure to outdoor air pollutants at their home address. Associations between personal air pollution exposure and asthma were comprehensively examined.Results: The occurrence of children's asthma was found to be linked to exposure to PM2.5 and NO2 during both the intrauterine and current periods, with significant ORs (95% CI) of 1.44 (1.08-1.93) and 1.29 (1.00-1.68) for IQR increase in intrauterine exposure particularly during the 2nd trimester, and 1.26 (1.01-1.57) and 1.26 (1.04-1.51) for exposure in previous year. Post-natal PM10 exposure was linked to asthma, with an OR (95% CI) of 1.28 (1.01-1.62). Higher risks of asthma were associated with intrauterine exposure to PM2.5 and postnatal exposure to PM10. The critical time windows for PM2.5, PM2.5-10, and PM10 exposure were identified as the entire pregnancy, the second trimester, and the entire postnatal period, respectively. Cumulative exposure to PM2.5 and NO2 during gestational weeks had a notable impact on asthma. Additionally, exposure to traffic-related air pollution (TRAP) at all timing stages, as well as PM2.5-10 and SO2 at night, increased the risk of asthma. Certain subgroups were more vulnerable to asthma risk due to air pollution.Conclusion: Children's asthma was predominantly influenced by exposure to particulate matters and TRAP during both the intrauterine and postnatal periods.
期刊：
FRONTIERS IN PSYCHIATRY,2023年14:1268539 ISSN：1664-0640
通讯作者：
Ma, SH;Zhao, X
作者机构：
[Wang, Weijun; Ma, SH; Ma, Shihao] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan, Peoples R China.;[Wang, Weijun; Ma, SH; Ma, Shihao; Han, Xinheng] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Wang, Weijun] Wuhan Technol & Business Univ, Inst Digital Commerce, Wuhan, Peoples R China.;[Han, Xinheng] Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan, Peoples R China.;[Zhao, X; Zhao, Xin] Univ Sheffield, Informat Sch, Sheffield, England.
通讯机构：
[Zhao, X ] U;[Ma, SH ] M;Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan, Peoples R China.;Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;Univ Sheffield, Informat Sch, Sheffield, England.
关键词：
anxiety;internet adaptability;internet addiction;meaning in life;serial mediation effect
摘要：
INTRODUCTION: Previous research has demonstrated the significant role of individual characteristics in adolescent Internet addiction. In line with this, our previous research has introduced the concept of "Internet adaptability" as a potential factor that enables individuals to effectively cope with the negative consequences of Internet use. However, further investigation is required to understand the impact of Internet adaptability on problematic Internet use, including Internet addiction, as well as its associated internal psychological factors. To address this research gap, the present study aims to examine the impact of Internet adaptability on internet addiction and explore the mediating roles of meaning in life and anxiety within this relationship. METHODS: A questionnaire was used to survey 2,144 adolescents from high schools in central China to investigate internet adaptability, meaning in life, anxiety, and internet addiction. RESULTS: The results revealed a significant negative correlation between Internet adaptability and adolescent internet addiction (r = -0.199, p < 0.01). Furthermore, our results indicated that Internet adaptability negatively predicts internet addiction (β = -0.086, p < 0.001). Additionally, mediation analyses revealed that both meaning in life (β = -0.060, p < 0.001) and anxiety (β = -0.032, p < 0.01) mediate the relationship between Internet adaptability and internet addiction. Moreover, a serial mediation effect involving meaning in life and anxiety was observed between Internet adaptability and internet addiction (β = -0.027, p < 0.001). CONCLUSION: These findings suggest that Internet adaptability plays an important role in alleviating individual internet addiction. Our results indicate that increasing individuals' sense of meaning in life can help reduce anxiety, thereby potentially reducing internet addiction.
期刊：
Human Brain Mapping,2023年44(10):4040-4051 ISSN：1065-9471
通讯作者：
Yue-Jia Luo<&wdkj&>Jiang Qiu
作者机构：
[Qiu, Jiang; Chen, Hong; Zhou, Zheyi; Wei, Dongtao] Southwest Univ, Fac Psychol, Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China.;[Zuo, Xi-Nian; Qin, Shaozheng; Zhou, Zheyi; Luo, Yue-Jia] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China.;[Liu, Wei] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Qin, Shaozheng] Beijing Normal Univ, Beijing Key Lab Brain Imaging & Connect, Beijing, Peoples R China.;[Zuo, Xi-Nian; Qin, Shaozheng] Beijing Normal Univ, McGovern Inst Brain Res, IDG, Beijing, Peoples R China.
通讯机构：
[Yue-Jia Luo] S;[Jiang Qiu] K;State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China<&wdkj&>Shenzhen Key Laboratory of Affective and Social Neuroscience, Magnetic Resonance Imaging Center, Center for Brain Disorders and Cognitive Sciences, Shenzhen University, Shenzhen, China<&wdkj&>Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, China<&wdkj&>Southwest University Branch, Collaborative Innovation Center of Assessment Toward Basic Education Quality, Beijing Normal University, Beijing, China
摘要：
The cognitive and behavioral development of children and adolescents is closely related to the maturation of brain morphology. Although the trajectory of brain development has been depicted in detail, the underlying biological mechanism of normal cortical morphological development in childhood and adolescence remains unclear. By combining the Allen Human Brain Atlas dataset with two single-site magnetic resonance imaging data including 427 and 733 subjects from China and the United States, respectively, we performed partial least squares regression and enrichment analysis to explore the relationship between the gene transcriptional expression and the development of cortical thickness in childhood and adolescence. We found that the spatial model of normal cortical thinning during childhood and adolescence is associated with genes expressed predominantly in astrocytes, microglia, excitatory and inhibitory neurons. Top cortical development-related genes are enriched for energy-related and DNA-related terms and are associated with psychological and cognitive disorders. Interestingly, there is a great deal of similarity between the findings derived from the two single-site datasets. This fills the gap between early cortical development and transcriptomes, which promotes an integrative understanding of the potential biological neural mechanisms.
摘要：
Age-related cognitive decline is a global phenomenon that affects individuals worldwide. The course and extent of this decline are influenced by numerous factors, such as genetics, lifestyle, education, and cognitive engagement. The theory of brain and cognitive reserve/maintenance posits that these factors have a significant impact on the degree of cognitive decline and overall brain health. However, the absence of standardized definitions and measurements for these terms creates ambiguity in research. To address this issue, we utilized a robust and systematic experimental paradigm, employing a considerably large subject pool comprising 17,030 participants from the UK Biobank. Utilizing advanced machine learning methodologies, we were able to accurately quantify both brain maintenance (BM) and cognitive maintenance (CM), making use of six distinct MRI modalities and nine distinct cognitive capabilities. Our study successfully identified several significant features that were meaningfully associated with both BM and CM outcomes. The results of our study demonstrate that lifestyle factors play a significant role in influencing both BM and CM through unique and independent mechanisms. Specifically, our study found that health status is a critical determinant of BM, while diabetes was found to be moderately associated with CM. Furthermore, our study revealed a positive correlation between BM/CM and cognitive reserve. By carefully considering the unique and independent mechanisms that govern both BM and CM, as well as their correlation with cognitive reserve, our study has provided valuable insight into the various strategies that may be leveraged to promote sustainable interventions to enhance cognitive and brain health across the lifespan.
摘要：
With the ever-changing social environment, individual creativity is facing a severe challenge induced by stress. However, little is known regarding the underlying mechanisms by which acute stress affects creative cognitive processing. The current research explored the impacts of the neuroendocrine response on creativity under stress and its underlying cognitive flexibility mechanisms. The enzyme-linked immuno sorbent assay was employed to assess salivary cortisol, which acted as a marker of stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis. Eye blink rate (EBR) and pupil diameter were measured as respective indicators of dopamine and noradrenaline released by the activation of the sympathetic-adrenal-medullary (SAM) axis. The Wisconsin card task (WCST) measured cognitive flexibility, while the alternative uses task (AUT) and the remote association task (RAT) measured separately divergent and convergent thinking in creativity. Results showed higher cortisol increments following acute stress induction in the stress group than control group. Ocular results showed that the stress manipulation significantly increased EBR and pupil diameter compared to controls, reflecting increased SAM activity. Further analysis revealed that stress-released cortisol impaired the originality component of the AUT, reducing cognitive flexibility as measured by perseverative errors on the WCST task. Serial mediation analyses showed that both EBR and pupil diameter were also associated with increased perseverative errors leading to poor originality on the AUT. These findings confirm that physiological arousal under stress can impair divergent thinking through the regulation of different neuroendocrine pathways, in which the deterioration of flexible switching plays an important mediating role. The current research is the first attempt to uncover the potential cognitive and neurophysiological mechanisms underlying creative processing under acute stress, providing a novel route to reducing stress and stress-related physiology. Moreover, the Dual Pathway to Creativity Model has been corroborated and extended for application in stressful situations.
