作者机构：
[Kai-Lu Zheng; An-Xin Wu] College of Chemistry, Central China Normal University
会议名称：
中国化学会第十一届全国天然有机化学学术会议
会议时间：
2016-09-25
会议地点：
中国上海
摘要：
<正>There has recently been a considerable increase in the development of new reactions for the preparation of cyclic amines and related alkaloids because of their potential pharmaceutical value and synthetic applications.1 Herein,we report the use of acrylates to capture the azomethine ylides generated in situ to develop a new reaction for the acidmediated N–H/α,β-C（sp3）–H trifunctionalization of pyrrolidine.This new reaction provides a
作者机构：
[张静静; 吴安心] College of Chemistry, Central China Normal University
会议名称：
中国化学会第十一届全国天然有机化学学术会议
会议时间：
2016-09-25
会议地点：
中国上海
摘要：
<正>A highly efficient molecular iodine mediated multicomponent reactions leading to 1,2,5-trisubstituted imidazoles from methyl ketones,anilines,and amino source（ammonium acetate,ammonium formate or tosylmethylisocyanide）was developed（Figure 1）.This protocol was envisioned that the substrate 1 could be divided into two sequences;and the corresponding intermediates B and 1’’could finally react with each other to converge on the
作者机构：
[李登奎; 蔡群; 周荣荣; 吴安心] College of Chemistry, Central China Normal University
会议名称：
中国化学会第十一届全国天然有机化学学术会议
会议时间：
2016-09-25
会议地点：
中国上海
摘要：
<正>The synthesis of O-hetercyclic compounds is a long-standing and continuing research topic due to its physicochemical and pharmacological properties with potential applications in the field of medicinal chemistry.1 Among them,2-hydroxy-2,3-dihydrofuran derivatives,serving as an important class of O-hetercyclic scaffolds,can be found in numerous natural products.2 Due to the great value of 2-hydroxy-2,3-dihydrofuran derivatives,various
作者机构：
[Jia Feng-Cheng; Wu An-Xin] Key Laboratory of Pesticide & Chemical Biology,Ministry of Education,College of Chemistry,Central China Normal University
会议名称：
中国化学会第十三届全国有机合成化学学术研讨会
会议时间：
2016-10-13
会议地点：
中国江苏扬州
摘要：
Organopromoted dehalogenative couplings between haloarenes and arenes are an important and active area in the synthetic chemistry.1 Continuous attention has been mainly focused on exploring new organi
作者机构：
[Cai Qun; Wu An-Xin] Key Laboratory of Pesticide & Chemical Biology,Ministry of Education,College of Chemistry,Central China Normal University
会议名称：
中国化学会第十三届全国有机合成化学学术研讨会
会议时间：
2016-10-13
会议地点：
中国江苏扬州
关键词：
tandem cyclization;polycyclic ring systems;arylglyoxal monohydrates;2-aminobenzylamine;trans-β-nitrostyrenes
摘要：
In recent years,tandem cyclization has emerged as a versatile and economical strategy for the synthesis of highly functionalized polycyclic ring systems,which has attracted substantial interest from chemists.In particular,tandem double cyclization has found wide applications in total synthesis of natural products because of its advantages in unparalleled efficiencies,reducing the reaction steps and waste production.1 4,9-Dihydropyrrolo[2,1-b]quinazoline and its derivatives can be found in numerous natural products and biologically active molecules such as vasicoline,2 vasicine3 and batracylin.4 Due to the importance and utility of 4,9-dihydropyrrolo[2,1-b]quinazoline derivatives,a simplified synthesis of this heteropolycyclic system offers great value.To the best of our knowledge,however,only a few approaches have been reported thus far to construct this novel structure.Herein,we have reported a new acid-catalyzed multicomponent reaction to construct polysubstituted 4,9-dihydropyrrolo[2,1-b]quinazolines from readily available arylglyoxal monohydrates,2-aminobenzylamine,and trans-β-nitrostyrenes in a single operation.Notably,this work represents a fascinating approach for the direct construction of three C-N bonds and one C-C bond via tandem double cyclization in a single step without any metal additives.
作者机构：
[Xu Cheng; Wu An-Xin] Key Laboratory of Pesticide & Chemical Biology,Ministry of Education,College of Chemistry,Central China Normal University
会议名称：
中国化学会第十三届全国有机合成化学学术研讨会
会议时间：
2016-10-13
会议地点：
中国江苏扬州
摘要：
In recent years,aryl azides have emerged as powerful synthons and exhibited enormous potential in metal-catalyzed N atom transfer reactions for the assembly of nitrogen-containing frameworks.1 Since t
摘要：
The pyrazole moiety is widely regarded as a privileged heterocyclic skeleton with broad pharmaceutical activities,including antitumor,antifungal,and inhibitory activities.Substituted pyrazoles have also been utilized as useful ligands for metal-catalyzed cross-coupling reactions.Therefore,the development of a highly efficient and regioselective method would be greatly valuable for the synthesis of polyfunctionalized pyrazoles from easily available substrates.Herein,a novel three-component reaction is presented for the synthesis of polysubstituted pyrazoles from simple arylglyoxal monohydrates,tosylhydrazine,and aldehydes with excellent regionselectivity under mild conditions.
作者机构：
[Miao Wang; Jungang Wang; Jiachen Xiang; Anxin Wu] Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University
会议名称：
中国化学会第九届全国有机化学学术会议
会议时间：
2015-07-28
会议地点：
中国吉林长春
摘要：
<正>The intermediate o-quinodimethane(o-QDM),has attracted much attention because it is useful and versatile building blocks in organic synthesis,fullerene chemistry,polymeric materials,medicinal chemi
作者机构：
[Cheng Xu; Feng-Cheng Jia; Zhi-Wen Zhou; An-Xin Wu] Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University
会议名称：
中国化学会第九届全国有机化学学术会议
会议时间：
2015-01-01
会议地点：
中国吉林长春
会议论文集名称：
中国化学会第九届全国有机化学学术会议论文摘要集(7)
摘要：
<正>1,3,4-Oxadiazoles represent a significant class of oxygen-containing heterocycles,which are ubiquitous in various biologically active and pharmaceutically important compounds.~1 In addition,they ha
作者机构：
[Feng-cheng Jia; An-xin Wu] Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University
会议名称：
中国化学会第九届全国有机化学学术会议
会议时间：
2015-07-28
会议地点：
中国吉林长春
摘要：
<正>Isatin and its derivatives represents an important and abundant class of nitrogen-containing heterocycles.1 Alough many methods were developed to synthesize isatins,2 no approaches have been reported for the construction of novel（E）-1-phenyl-2-（phenylimino）indolin-3-ones.Herein we
作者机构：
[Shan Liu; Qinghe Gao; Xia Wu; Jingjing Zhang; Anxin Wu] Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University
会议名称：
中国化学会第九届全国有机化学学术会议
会议时间：
2015-01-01
会议地点：
中国吉林长春
会议论文集名称：
中国化学会第九届全国有机化学学术会议论文摘要集(7)
摘要：
<正>iImidazo[1,2-a]pyridine nucleus is a privileged fragment present in various biologically active and pharmaceutically important compounds.1 Consequently,much attention has been paid to the synthesis of substituted imidazo[1,2-a]pyridine through construction of imidazo[1,2-a]pyridine ring.2 However,the
作者机构：
[庞韬; 吴安心] Key Laboratory of Pesticide & Chemical Biology,Ministry of Education,College of Chemistry,Central China Normal University;[庞韬; 吴安心] Anhui Key Laboratory of Funcitional Coordination Compounds,School of Chemistry & Chemistry Engineering,Anqing Normal University
会议名称：
中国化学会全国第十二届有机合成化学学术研讨会
会议时间：
2015-10-15
会议地点：
中国广西桂林
摘要：
The unusual and unexpected effects which can result from heterogeneous metal catalysts~[1] provide much potential for the efficient construction of complex molecules from starting simple materials.The
作者机构：
[Xia Wu; Qinghe Gao; Shan Liu; Jingjing Zhang; Anxin Wu] Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University
会议名称：
中国化学会第九届全国有机化学学术会议
会议时间：
2015-07-28
会议地点：
中国吉林长春
摘要：
<正>The direct methylenation or methylation of C-H bond and heteroatom–H bond,especially methylenation or methylation of Csp3–H bond and N–H bond,is one of the most important transformation in organ
作者机构：
[Jun-Rui Ma; An-Xin Wu] Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University
会议名称：
中国化学会第九届全国有机化学学术会议
会议时间：
2015-07-28
会议地点：
中国吉林长春
摘要：
<正>The 2-hydroxy-2,3-dihydrofuran moiety widely exist in many natural products and pharmacological molecules（e.g.,Auranfuron A and B,Siphonarienfuranone,Drimanes,Hydroxyfuranone）,1,2 which exhibit
作者机构：
[向嘉辰; 吴安心] Key Laboratory of Pesticide & Chemical Biology,Ministry of Education,College of Chemistry,Central China Normal University
会议名称：
中国化学会全国第十二届有机合成化学学术研讨会
会议时间：
2015-10-15
会议地点：
中国广西桂林
摘要：
Pyridine is widely found in natural products,pharmaceuticals and functional materials,which becomes one of the most important N-containing aromatics.Traditional pyridine synthesis mainly relied on ald
