作者机构：
[Li, Tian-Ren; Tunge, Jon A.; Maliszewski, Mary L.] Univ Kansas, Dept Chem, 2010 Malott Hall,1251 Wescoe Hall Dr, Lawrence, KS 66045 USA.;[Li, Tian-Ren; Tunge, Jon A.; Maliszewski, Mary L.] KU Chem Methodol & Lib Dev Ctr Excellence, 2034 Becker Dr, Lawrence, KS 66047 USA.;[Li, Tian-Ren; Xiao, Wen-Jing] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Tunge, Jon A.] U;[Tunge, Jon A.] K;Univ Kansas, Dept Chem, 2010 Malott Hall,1251 Wescoe Hall Dr, Lawrence, KS 66045 USA.;KU Chem Methodol & Lib Dev Ctr Excellence, 2034 Becker Dr, Lawrence, KS 66047 USA.
摘要：
A palladium-catalyzed decarboxylative coupling of enol carbonates with diarylmethyl electrophiles that are derived from secondary benzylic alcohols has been developed. This method allows the generation of a variety of β-diaryl ketones through an efficient and highly stereospecific coupling. In addition, detailed mechanistic insight into the coupling suggests that the reaction is a rare example of an intramolecular decarboxylative coupling that proceeds without crossover between reactants.
作者机构：
[Chen J.-R.; Hu X.-Q.; Xiao W.-J.] CCNU-uOttawa Joint Research Center, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China
通讯机构：
[Jia-Rong Chen; Wen-Jing Xiao] C;CCNU-uOttawa Joint Research Center, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China
作者机构：
[Xiao, Wen-Jing; Chen, Jun; Yang, Meng-Nan; Chen, Jia-Rong] Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, CCNU uOttawa Joint Res Ctr, Minist Educ,Key Lab Pesticides & Chem Biol,Coll C, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China.
通讯机构：
[Chen, Jia-Rong] C;Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, CCNU uOttawa Joint Res Ctr, Minist Educ,Key Lab Pesticides & Chem Biol,Coll C, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要：
The first example of a Pd(OAc)2-catalyzed ring-forming alkene aminoaroylation of unsaturated hydrazones and sulfonamides is described. This protocol features the use of diaryliodonium salts as both oxidants and aryl sources, thus enabling mild reaction conditions, good chemoselectivity, a broad substrate scope, and high functional group tolerance. A wide range of synthetically and biologically important functionalized dihydropyrazoles and isoxazolidines have been obtained in good yields.
作者机构：
[Lu, Liang-Qu; Xiao, WJ; Liu, Jing; Xiao, Wen-Jing; Zhou, Quan-Quan; Ding, Wei; Liu, Dan] Cent China Normal Univ, Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.
通讯机构：
[Lu, LQ; Xiao, WJ] C;[Xiao, Wen-Jing] L;Cent China Normal Univ, Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.
摘要：
Efficient and enantioselective radical difluoroalkylation and perfluoroalkylation reactions of β-ketoesters were successfully developed through an asymmetric photoredox and nickel catalysis cascade. This protocol provides Rf-containing quaternary stereocenters in up to 67% yield and 95:5 er with ethyl iododifluoroacetate and perfluoroalkyl iodides (C3F7I and C4F9I) as radical sources under extremely mild conditions.
作者机构：
[Feng, Bin; Ye, Hui; Lu, Bin; Xiao, Wen-Jing; Chen, Jia-Rong] Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Key Lab Pesticides & Chem Biol, CCNU uOttawa Joint Res Ctr,Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Ye, Hui; Xiao, Wen-Jing] Huanggang Normal Univ, Hubei Key Lab Proc & Applicat Catalyt Mat, Huanggang 438000, Hubei, Peoples R China.;[Xiao, Wen-Jing] Cent China Normal Univ, Key Lab Pesticides & Chem Biol, CCNU uOttawa Joint Res Ctr,Minist Educ,Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Xiao, Wen-Jing] C;[Xiao, Wen-Jing] H;Cent China Normal Univ, Key Lab Pesticides & Chem Biol, CCNU uOttawa Joint Res Ctr,Minist Educ,Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;Huanggang Normal Univ, Hubei Key Lab Proc & Applicat Catalyt Mat, Huanggang 438000, Hubei, Peoples R China.
摘要：
A general and efficient Pd/phosphoramidite thioether complex-catalyzed asymmetric N-allylic alkylation of hydrazones with allylic acetates has been developed for the first time. The reaction allows for the preparation of various valuable N-substituted hydrazones with generally good yields and excellent enantioselectivities. Minor structural modification of the ligand resulted in opposite enantiomers, enabling enantiodivergent synthesis of products by the same catalytic system.
期刊：
Chemical Communications,2018年54(50):6780-6783 ISSN：1359-7345
通讯作者：
Chen, Jia-Rong
作者机构：
[Zhao, Quan-Qing; Guo, Hong-Mei; Xiao, Wen-Jing; Chen, Jun; Chen, Jia-Rong] Cent China Normal Univ, CCNU uOttawa Joint Res Ctr, Hubei Int Sci & Technol Cooperat Base Pesticide &, Key Lab Pesticide & Chem Biol,Minist Educ,Coll Ch, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
通讯机构：
[Chen, Jia-Rong] C;Cent China Normal Univ, CCNU uOttawa Joint Res Ctr, Hubei Int Sci & Technol Cooperat Base Pesticide &, Key Lab Pesticide & Chem Biol,Minist Educ,Coll Ch, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要：
A visible light-driven photocatalytic generation of sulfonamidyl radicals, and application to intramolecular alkene hydroamination, has been accomplished, providing a mild and efficient approach to various functionalized isoxazolidines. The success of this protocol is based on the strategy of oxidative deprotonation electron transfer by merging the base and the photocatalyst under visible light irradiation, obviating installation of a photolabile handle or stoichiometric external oxidants.
作者机构：
[Lu, Liang-Qiu; Li, Tian-Ren; Wang, Bao-Cheng; Xiao, Wen-Jing; Zhang, Mao-Mao] Cent China Normal Univ, Coll Chem, Minist Educ, CCNU uOttawa Joint Res Ctr,Key Lab Pesticide & Ch, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Huanggang Normal Coll, Hubei Key Lab Proc & Applicat Catalyt Mat, Huanggang 438000, Peoples R China.
通讯机构：
[Lu, Liang-Qiu] C;Cent China Normal Univ, Coll Chem, Minist Educ, CCNU uOttawa Joint Res Ctr,Key Lab Pesticide & Ch, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要：
A copper-catalyzed Friedel–Crafts propargylation/hydroamination/aromatization sequence is described. In the presence of a catalytic amount of CuI, this sequential reaction can convert ethynyl benzoxazinanones and indoles into a diverse set of 3,3′-biindoles with high efficiency and selectivity. Moreover, the synthesis of other indole–heteroaryl molecules and the catalytic asymmetric formation of axially chiral 3,3′-biindoles are demonstrated.
作者机构：
[Cong Xiao] Department of Chemistry, Georgia State University, Atlanta, GA, 30302-4098, United States;[Wen-Jing Xiao] CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide &, Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, China
通讯机构：
[Wen-Jing Xiao] C;CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China
关键词：
《中国科学:化学英文版》;期刊;编辑工作;发行工作
摘要：
The activation of inert C(sp~3)–H bonds with control of reactivity and selectivity is one of the central topics in chemical sciences. In this context, alkoxy radical-mediated 1,5- hydrogen atom transfer allows the regioselective transformation of inert C(sp~3)–H bonds to access functionalized molecules which would otherwise be inaccessible. Although some preliminary but elegant results have been disclosed, this chemistry remains challenging and largely underexploited for the following reasons: (1) the bond dissociation energy of O–H bonds is quite high (105 kcal/mol), and therefore the direct formation of alkoxy radicals from alcohols is truly difficult; and (2) the transient alkoxy radicals are too reactive to harness in many cases. Accordingly, various prefunctionalized precursors (e.g., peroxy compounds, nitrite esters, hypohalites, N-alkoxylpyridine-2-thiones, N-alkoxyphthalimides, etc.) are usually employed to generate alkoxy radicals. Despite advances, the development of catalytic approaches for the straightforward conversion of alcohols to alkoxy radicals under mild and environmentally friendly are highly desirable [1].
作者机构：
[Chen, Jia-Rong; Xiao, WJ; Xiao, Wen-Jing; Zhou, Quan-Quan; Yu, Xiao-Ye; Wang, Peng-Zi; Liao, Chun-Miao] Cent China Normal Univ, Coll Chem,Minist Educ, Key Lab Pesticides & Chem Biol,CCNU uOttawa Joint, Hubei Int Sci & Technol Cooperat Base Pesticide &, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Huanggang Normal Univ, Hubei Key Lab Proc & Applicat Catalyt Mat, Huanggang 438000, Hubei, Peoples R China.
通讯机构：
[Chen, JR; Xiao, WJ] C;[Xiao, Wen-Jing] H;Cent China Normal Univ, Coll Chem,Minist Educ, Key Lab Pesticides & Chem Biol,CCNU uOttawa Joint, Hubei Int Sci & Technol Cooperat Base Pesticide &, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;Huanggang Normal Univ, Hubei Key Lab Proc & Applicat Catalyt Mat, Huanggang 438000, Hubei, Peoples R China.
摘要：
A dual visible light photoredox and nickel-catalyzed cross-coupling reaction of 2-arylaziridines and potassium benzyltrifluoroborates is described for the first time. This strategy features high functional group tolerance, exclusive regioselectivity for reaction at the more hindered C–N bond, easily accessible substrates, and mild redox-neutral reaction conditions. A variety of diversely substituted β-substituted amines are obtained in generally good yields.
作者机构：
[Lu, LQ; Xiao, WJ; Lu, Liang-Qiu; Li, Tian-Ren; Wang, Ya-Ni; Wang, Bao-Cheng; Xiao, Wen-Jing] Cent China Normal Univ, Coll Chem, Minist Educ,Key Lab Pesticide & Chem Biol, Hubei Int Sci & Technol Cooperat Base Pesticide &, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China.
通讯机构：
[Lu, LQ; Xiao, WJ; Xiao, Wen-Jing] C;Cent China Normal Univ, Coll Chem, Minist Educ,Key Lab Pesticide & Chem Biol, Hubei Int Sci & Technol Cooperat Base Pesticide &, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China.
摘要：
Polycyclic indolines are the common and core structural motif of many indole alkaloids that usually exhibit biological activities. Here, we describe two copper-catalyzed cascade reactions between propargylic carbamates and indoles. By doing so, one-step and divergent synthesis of structurally distinct polycyclic indolines, quinoline-fused indolines, C(3a)-indolyl furoindolines, and pyrroloindolines was achieved in high synthetic efficiency and selectivity.
作者机构：
[刘以银; 余晓叶; 陈加荣; 杨梦楠; 肖文精] College of Chemistry, Central China Normal University;[刘以银; 余晓叶; 陈加荣; 杨梦楠; 肖文精] 华师-渥太华大学国际联合研究中心,华中师范大学化学学院;[刘以银; 余晓叶; 陈加荣; 杨梦楠; 肖文精] 农药与化学生物学教育部重点实验室,华中师范大学化学学院
作者机构：
[Xiao, Wen Jing; Zhao, Quan-Qing; Chen, Jia-Rong; Xiao, WJ; Yang, Meng-Nan; Yan, Dong-Mei] Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Key Lab Pesticides & Chem Biol, CCNU uOttawa Joint Res Ctr,Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen Jing] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China.
通讯机构：
[Chen, JR; Xiao, WJ] C;[Xiao, Wen Jing] S;Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Key Lab Pesticides & Chem Biol, CCNU uOttawa Joint Res Ctr,Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China.
摘要：
A ligand-free, palladium-catalyzed aminoarylation reaction of the unactivated alkenes in β,γ-unsaturated hydrazones is described. This protocol enables efficient and simultaneous formation of C(sp3)–N and C(sp3)–C(sp2) bonds under mild conditions, providing a practical and general approach to various diversely substituted dihydropyrazoles in generally good yields, without the use of any stoichiometric external oxidant.
作者：
Xiao-Qiang Hu;Dr. Jia-Rong Chen;Prof. Dr. Wen-Jing Xiao;Xiao-Qiang Hu Xiao-Qiang Hu Xiao-Qiang Hu;Dr. Jia-Rong Chen Dr. Jia-Rong Chen Dr. Jia-Rong Chen;...
作者机构：
[Xiao-Qiang Hu; Dr. Jia-Rong Chen; Prof. Dr. Wen-Jing Xiao; Xiao-Qiang Hu Xiao-Qiang Hu Xiao-Qiang Hu; Dr. Jia-Rong Chen Dr. Jia-Rong Chen Dr. Jia-Rong Chen; Prof. Dr. Wen-Jing Xiao Prof. Dr. Wen-Jing Xiao Prof. Dr. Wen-Jing Xiao] CCNU-uOttawa Joint Research Center, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079 China
通讯机构：
[Dr. Jia-Rong Chen; Prof. Dr. Wen-Jing Xiao; Dr. Jia-Rong Chen Dr. Jia-Rong Chen Dr. Jia-Rong Chen; Prof. Dr. Wen-Jing Xiao Prof. Dr. Wen-Jing Xiao Prof. Dr. Wen-Jing Xiao] C;CCNU-uOttawa Joint Research Center, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079 China
关键词：
alkylation;C−H functionalization;hydrogen atom transfer;photoredox catalysis;radicals
摘要：
Remote control: New strategies for the activation of remote C(sp3 )-H bonds by photoredox-catalyzed (PC) radical translocation via O- and N-centered radicals have recently been described. These methods enable the controlled and site-selective functionalization of inert C(sp3 )-H bonds and provide new opportunities for reaction design (HAT=hydrogen atom transfer).
