期刊：
Journal of Heterocyclic Chemistry,2015年52(3):647-652 ISSN：0022-152X
通讯作者：
Ren, Qingyun
作者机构：
[He, Hongwu; Gu, Yucheng; Ren, Qingyun] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Li, Baoju; Xia, ShiYan] Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China.;[Gu, Yucheng] Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England.;[Ren, Qingyun] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构：
[Ren, Qingyun] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
摘要：
Fifteen novel 2-alkylamino-3-aryl-8-cyano-5-methyl-7-(methylthio)-pyrido[4,3-d]pyrimidin-4(3H)-ones 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j, 6k, 6l, 6m, 6n, 6o were designed and have been successfully synthesized via tandem aza-Wittig and annulation reactions with the corresponding iminophosphoranes 4, aryl isocyanate, and amines in good yields. Their structures were clearly verified by IR spectroscopy, 1H-NMR spectroscopy, EI-MS, and elemental analysis, and in the case of compound 6i, further analyzed by single-crystal X-ray diffraction. The preliminary results of an in vivo bioassay showed that some compounds display moderate antifungal activity.
期刊：
Journal of Heterocyclic Chemistry,2015年52(1):173-179 ISSN：0022-152X
通讯作者：
Peng, Hao
作者机构：
[Peng, Hao] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan, Peoples R China.;Cent China Normal Univ, Coll Chem, Wuhan, Peoples R China.
通讯机构：
[Peng, Hao] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan, Peoples R China.
摘要：
A series of novel O,O‐dimethyl 1‐(substituted phenoxyacetoxy)‐1‐(pyridin‐2‐yl or thien‐2‐yl)methylphosphonates 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j, 6k, 6l, 6m, 6n and 7a, 7b, 7c, 7d were synthesized. Their structures were confirmed by IR, 1H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. For example, the title compounds 6a, 6c, 6l, 6m, and 7d possess 90–100% inhibition against most of the tested plants at the dosage of 1500 g ai/ha, whereas the title compounds 6b, 6g, 6h and 6n possess 92–100% inhibition against Fusarium oxysporum, Phyricularia grisea, Botrytis cinereapers, Gibberella zeae, Sclerotinia sclerotiorum, and Cercospora beticola at the concentration of 50 mg/L.
期刊：
Journal of Heterocyclic Chemistry,2015年52(4):1260-1263 ISSN：0022-152X
通讯作者：
He, Hongwu
作者机构：
[He, Hongwu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan, Peoples R China.;Cent China Normal Univ, Coll Chem, Wuhan, Peoples R China.
通讯机构：
[He, Hongwu] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan, Peoples R China.
摘要：
A three-dimensional quantitative structure–activity relationship (3D-QSAR) study was performed on two different chemical series, which have great herbicidal activity, employing comparative molecular field analysis (CoMFA) and comparative molecular similarity indices (CoMSIA) techniques to further investigate the structural requirement for the dicotyledonous stem inhibition. The optimal CoMFA and CoMSIA models obtained for the training set were all statistically significant with cross-validated coefficients (q2) of 0.702, 0.726 and conventional coefficients (R2) of 0.980, 0.963, respectively. These models were validated by a set of six molecules that were not included in the training set. The CoMFA yielded comparable models for phosphonate and phosphinate derivatives highlighting the significance of steric and electrostatic fields toward dicotyledonous stem inhibitory activity. The CoMSIA models indicated the importance of electrostatic and hydrophobic fields toward dicotyledonous stem inhibitory activity. The CoMSIA steric and electrostatic field maps are in accordance with field distribution of CoMFA maps and consistent with structure–activity relationships.
作者机构：
[Liu Jianchao; He Hongwu] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.;[Ren Qingyun] Sunshine Lake Pharma Co Ltd, New Drug Res Inst, Antiinfect Innovat Dept, Dongguan 523871, Peoples R China.
通讯机构：
[Liu Jianchao] C;Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
关键词：
多取代吡啶;六水合硝酸锌;β-二羰基化合物;杀菌活性;除草活性
摘要：
采用六水合硝酸锌作催化剂、少量的乙醇钠为助催化剂,使用无水乙醇作为溶剂,将2-氰基-3-烷胺基-3-氨基-丙烯腈(N,N-缩醛)与β-二羰基化合物一步关环生成了一系列目标化合物4-氨基-5-氰基-6-烷胺基吡啶衍生物.通过~1H NMR, IR, EI-MS,元素分析等方法对所合成的化合物进行了结构表征.代表化合物2-甲基-4-氨基-5-氰基-6-乙醇胺基- 3-乙氧羰基吡啶经单晶X衍射证实了结构.对合成的多取代吡啶衍生物化合物作了初步的农药活性测试,测试结果表明:所合成的多取代吡啶衍生物部分化合物表现出较好的杀菌活性,同时也对油菜和稗草具有一定的除草活性.
期刊：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS,2015年190(7):972-977 ISSN：1042-6507
通讯作者：
Peng, Hao
作者机构：
[He, Hongwu; Peng, Hao; Gao, Yujiao; Wang, Tao] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan, Hubei, Peoples R China.;[Wang, Tao] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang, Jiangxi, Peoples R China.
通讯机构：
[Peng, Hao] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan, Hubei, Peoples R China.
关键词：
Synthesis;herbicidal activity;phosphinate
摘要：
A series of sodium methyl(α-(substituted phenoxyacetoxy)alkyl)phosphinates was designed and synthesized. Their structures were confirmed by IR, 1H NMR and elemental analysis, and some of them were further confirmed by MS. The results of bioassay showed that most of title compounds exhibited moderate to good herbicidal activities against the root of barnyard grass and rape at 10∼100 mg/L.
摘要：
以商品化的杀菌剂噻唑菌胺和噻氟酰胺为先导,保持噻唑环活性结构,在噻唑环的4位引入酯基,设计合成了9个新型的4-取代苯甲酰氧基-2-取代苯甲酰氨基噻唑衍生物,中间体2-亚氨基-4-噻唑烷酮由简便易得的原料溴乙酸乙酯与硫脲一步合成.用IR、1 H NMR、13 C NMR、MS和元素分析等对合成的噻唑酰胺化合物结构进行了表征.并对其杀菌和抗肿瘤生物活性进行了测试,初步的研究结果表明,该类化合物基本上没有抗肿瘤活性,但部分化合物对小麦赤霉病和黄瓜灰霉病有较好的抑制效果.
关键词：
Herbicide;Ultrastructure;Gene transcript;N and P absorption
摘要：
Both 2-[(2,4-dichlorophenoxy)acetoxy](methy)lmethyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one (termed as IIa) and 2-[(4-chloro-2-methyl-phenoxy)-acetoxy](methyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one (termed as IIr) are novel herbicide candidates that positively affect herbicidal activity via the introduction of a phosphorus-containing heterocyclic ring. This report investigated the mechanism of IIa and IIr on weed control in the model plant Arabidopsis thaliana at physiological, ultrastructural and molecular levels. IIa and IIr significantly inhibited the growth of A. thaliana and altered its root structure by inhibiting energy metabolism and lipid or protein biosynthesis. These compounds also significantly affected the absorption of nitrogen and phosphorus by down-regulating the transcripts of nitrate transporterrelated genes, ammonium transporter-related genes and phosphorus transporter-related genes. (C) 2015 Elsevier Inc. All rights reserved.
摘要：
To identify new antifungal lead compound based on inhibitors of pyruvate dehydrogenase complex E1, a series of 5-iodo-1,4-disubstituted-1,2,3-triazole derivatives 3 were prepared and evaluated for their Escherichia coli PDHc-E1 inhibitory activity and antifungal activity. The in vitro bioassay for the PDHc-E1 inhibition indicated all the compounds exhibited significant inhibition against E. coli PDHc-E1 (IC50 < 21 mu M), special compound 3g showed the most potent inhibitory activity (IC50 = 4.21 +/- 0.11 mu M) and was demonstrated to act as a competitive inhibitor of PDHc-E1. Meanwhile, inhibitor 3g exhibited very good enzyme-selective inhibition of PDHc-E1 between pig heart and E. coli. The assay of antifungal activity showed compounds 3e, 3g, and 3n exhibited fair to good activity against Rhizoctonia solani and Botrytis cinerea even at 12.5 mu g/mL. Especially compound 3n (EC50 = 5.4 mu g/mL; EC90 = 21.1 mu g/mL) exhibited almost 5.50 times inhibitory potency against B. cinerea than that of pyrimethanil (EC50 = 29.6 mu g/mL; EC90 = 113.4 mu g/mL). Therefore, in this study, compound 3n was found to be a novel lead compound for further optimization to find more potent antifungal compounds as microbial PDHc-E1 inhibitors. (C) 2015 Elsevier Ltd. All rights reserved.
摘要：
Convenient approach to synthesize tertiary α-hydroxy cyclic phosphonates catalyzed by potassium carbonate under solvent-free conditionsAll authorsChubei Wanga*, Jianwei Zhoua, Jianfeng Liub, Liangliang Chua & Hongwu HecDOI:http://dx.doi.org/10.1080/10426507.2013.860532Published online:15 September 2014PowerPoint slideOriginal jpg (14.00KB)Display full sizeA new environmentally benign, convenient, and easy method for the synthesis of tertiary α-hydroxy cyclic phosphonates was developed. In the presence of potassium carbonate, aromatic/heteroaromatic ketones and base-sensitive ketones can react with phosphite to form tertiary α-hydroxyphosphonates under solvent-free and mild conditions.
