期刊论文

Liu, Zheng(liuz1118@ccnu.edu.cn);Luo, Rui(luorui@mail.hzau.edu.cn)

英文

Carbohydrate Research

0008-6215

2022

513

108527

10.1016/j.carres.2022.108527

This work was supported by the National Natural Science Foundation of China (No. 21977034 ), self-determined research funds of CCNU from the colleges' basic research and operation of MOE (No. CCNU20TS014 ), Fundamental Research Funds for the Central Universities (No. 2662019PY078 ), the fund from Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education (No. LKF2021003 ), and Program of Introducing Talents of Discipline to Universities of China (111 program, B17019 ).

本校为其他机构

iNKT cells are a special type of T cell that acts as a link between the innate and adaptive immune systems, with the capacity to stimulate a wide range of cell types. The glycolipid α-galactosylceramide (αGC) is a robust agonist of iNKT cells and induces the secretion of Th1- and Th2-type cytokines. αGC and its analogs are widely used as adjuvants to enhance immune responses against viral, parasitic, and bacterial pathogens. This review first discusses the challenges of using free αGC as a vaccine adjuvant to treat infectious diseases. We n...