National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11775091, 11474117]
机构署名：
本校为第一且通讯机构
院系归属：
物理科学与技术学院
摘要：
Based on the coherent feedforward transcription regulation loops in somatic cell reprogramming process, a stochastic kinetic model is proposed to study the intrinsic fluctuations in the somatic cell reprogramming. The Fano factor formulas of key genes expression level in the coherent feedforward transcription regulation loops are derived by using of Langevin theory. It is found that the internal fluctuations of gene expression levels mainly depend on itself activation ratio and degradation ratio. When the self-activation ratio (or self-degradat...
