Interpretable deep residual network uncovers nucleosome positioning and associated features

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成果类型：

期刊论文

作者：

Masoudi-Sobhanzadeh, Yosef;Li, Shuxiang;Peng, Yunhui;Panchenko, Anna R.

通讯作者：

Panchenko, AR

作者机构：

[Panchenko, Anna R.; Masoudi-Sobhanzadeh, Yosef; Panchenko, AR; Li, Shuxiang] Queens Univ, Dept Pathol & Mol Med, Kingston, ON K7L3N6, Canada.

[Peng, Yunhui] Cent China Normal Univ, Inst Biophys, Wuhan 430079, Peoples R China.

[Peng, Yunhui] Cent China Normal Univ, Dept Phys, Wuhan 430079, Peoples R China.

[Panchenko, Anna R.; Panchenko, AR] Queens Univ, Dept Biol & Mol Sci, Kingston, ON K7L3N6, Canada.

[Panchenko, Anna R.; Panchenko, AR] Queens Univ, Sch Comp, Kingston, ON K7L3N6, Canada.

通讯机构：

[Panchenko, AR ] Q

Queens Univ, Dept Pathol & Mol Med, Kingston, ON K7L3N6, Canada.

Queens Univ, Dept Biol & Mol Sci, Kingston, ON K7L3N6, Canada.

Queens Univ, Sch Comp, Kingston, ON K7L3N6, Canada.

Ontario Inst Canc Res, Toronto, ON M5G 0A3, Canada.

语种：

英文

期刊：

Nucleic acids research

ISSN：

0305-1048

年：

2024

DOI：

10.1093/nar/gkae623

基金类别：

Ontario Institute for Cancer Research; Government of Ontario

机构署名：

本校为其他机构

院系归属：

物理科学与技术学院

心理学院

摘要：

Nucleosomes represent elementary building units of eukaryotic chromosomes and consist of DNA wrapped around a histone octamer flanked by linker DNA segments. Nucleosomes are central in epigenetic pathways and their genomic positioning is associated with regulation of gene expression, DNA replication, DNA methylation and DNA repair, among other functions. Building on prior discoveries that DNA sequences noticeably affect nucleosome positioning, our objective is to identify nucleosome positions and related features across entire genome. Here, we introduce an interpretable framework based on the ...

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Interpretable deep residual network uncovers nucleosome positioning and associated features

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