Graphene Oxide Based Recyclable in Vivo Device for Amperometric Monitoring of Interferon-γ in Inflammatory Mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cao, Chaomin;Jin, Ronghua;Wei, Hui;Yang, Wenchao;Goldys, Ewa M.;...

通讯作者：

Liu, Guozhen;Chen, Xin

作者机构：

[Cao, Chaomin; Yang, Guangfu; Yang, Wenchao; Liu, Guozhen; Wei, Hui] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Hubei, Peoples R China.

[Chen, Xin; Jin, Ronghua] Xi An Jiao Tong Univ, Inst Polymer Sci Chem Engn, Shanxi Key Lab Energy Chem Proc Intensificat, Sch Chem Engn & Technol, Xian 710049, Shaanxi, Peoples R China.

[Goldys, Ewa M.; Liu, Guozhen] Univ New South Wales, ARC Ctr Excellence Nanoscale BioPhoton CNBP, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia.

[Hutchinson, Mark R.] Univ Adelaide, ARC Ctr Excellence Nanoscale BioPhoton CNBP, Adelaide, SA 5000, Australia.

[Hutchinson, Mark R.] Univ Adelaide, Adelaide Med Sch, Discipline Physiol, Adelaide, SA 5005, Australia.

通讯机构：

[Liu, Guozhen] C

[Chen, Xin] X

[Liu, Guozhen] U

Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Hubei, Peoples R China.

Xi An Jiao Tong Univ, Inst Polymer Sci Chem Engn, Shanxi Key Lab Energy Chem Proc Intensificat, Sch Chem Engn & Technol, Xian 710049, Shaanxi, Peoples R China.

语种：

英文

关键词：

cytokines;graphene oxides;in vivo sensing device;interferon-γ;structure-switching aptamers

期刊：

ACS Applied Materials & Interfaces

ISSN：

1944-8244

年：

2018

卷：

期：

页码：

33078-33087

DOI：

10.1021/acsami.8b13518

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21575045]; ARC Future FellowshipAustralian Research Council [FT160100039]; ARC Centre of Excellence for Nanoscale BiophotonicsAustralian Research Council [CE140100003]

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

Cytokine sensing is challenging due to their typically low abundances in physiological conditions. Nanomaterial fabricated interfaces demonstrated unique advantages in ultrasensitive sensing. Here, we demonstrate an amperometric sensing device based on graphene oxide (GO) and structure-switching aptamers for long-term detection of cytokines in a living organism. The device incorporates a single layer of GO acting as a signal amplifier on glassy carbon electrodes. The hairpin aptamers specific to interferon-γ (IFN-γ), which were loaded with re...

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Graphene Oxide Based Recyclable in Vivo Device for Amperometric Monitoring of Interferon-γ in Inflammatory Mice

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