期刊论文

Zhang, Luoping;Li, Rui

英文

Archives of Toxicology

0340-5761

2021

95

2

693-701

10.1007/s00204-020-02932-x

This project was partially supported by NIEHS Superfund research grant P42ES004705 and Chau Hoi Shuen Foundation Women in Science Program Award at University of California at Berkeley (L Zhang), as well as the National Key Research and Development Program of China (2017YFC0702700) (R Li). The content is solely the responsibility of the authors and does not necessarily represent the official views of NIEHS and other funding agencies. We thank Dr. Zhe Liu from University of California, San Francisco (UCSF) at Dr. Looney's lab for her valuable suggestions on the protocol of lung cell extraction. YZ is a recipient of the China Scholarship Council for a graduate fellowship to UC Berkeley for 2 years (201706770048).

本校为通讯机构

Formaldehyde (FA), an economically important and ubiquitous chemical, has been classified as a human carcinogen and myeloid leukemogen. However, the underlying mechanisms of leukemogenesis remain unclear. Unlike many classical leukemogens that damage hematopoietic stem/progenitor cells (HSC/HPC) directly in the bone marrow, FA—as the smallest, most reactive aldehyde—is thought to be incapable of reaching the bone marrow through inhalation exposure. A recent breakthrough study discovered that mouse lung contains functional HSC/HPC that can pro...