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Glycosylation modification identifies novel molecular phenotypes and prognostic stratifications of glioma

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成果类型:
期刊论文
作者:
Wang, Chaofan;Xiong, Kewei
通讯作者:
Kewei Xiong
作者机构:
[Wang, Chaofan] Capital Med Univ, Sch Publ Hlth, Beijing 100069, Peoples R China.
[Xiong, Kewei] Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Peoples R China.
[Xiong, Kewei] Cent China Normal Univ, Sch Math & Stat, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Xiong, K.] S
School of Mathematics and Statistics, #152 Luoyu Road, Hongshan District, Hubei Province, China
语种:
英文
关键词:
Glioma;Glycosylation;Prognosis;Subtype;Tumor microenvironment
期刊:
Gene
ISSN:
0378-1119
年:
2022
卷:
836
页码:
146677
基金类别:
None.
机构署名:
本校为其他机构
院系归属:
数学与统计学学院
摘要:
Glycosylation modification plays a vital role in tumor progression and is highly associated with glioma prognosis. However, the influence of glycosylation modification on the tumor microenvironment (TME) and omic features of glioma remains unclear. Differentially expressed glycosylation-related genes between adjacent and tumor tissues of The Cancer Genome Atlas and Chinese Glioma Genome Atlas datasets were identified. We performed unsupervised clustering to classify patients into different molecular phenotypes, and analyzed their TME heterogene...

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