Vasodilatory effect of formaldehyde via the NO/cGMP pathway and the regulation of expression of KATP, BKCa and L-type Ca(2+) channels.

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成果类型：

期刊论文

作者：

Zhao, Yun;Ge, Jing;Li, Xiaoxiao;Guo, Qing;Zhu, Yuqing;...

通讯作者：

Yang, Xu;Li, Rui

作者机构：

[Guo, Qing; Yang, X; Li, R; Li, Rui; Li, Xiaoxiao; Yang, Xu; Zhao, Yun; Song, Jing; Ge, Jing; Ding, Shumao] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.

[Zhang, Luoping] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.

[Guo, Qing] Huazhong Univ Sci & Technol, Sch Publ Hlth, Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.

[Zhu, Yuqing] Zhejiang Univ, Sch Med, Ctr Stem Cell & Regenerat Med, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.

通讯机构：

[Yang, X; Li, R] C

Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.

语种：

英文

关键词：

Formaldehyde;Ion channels;NO/cGMP pathway;Rat aortas;Vasorelaxation

期刊：

Toxicology Letters

ISSN：

0378-4274

年：

2019

卷：

312

页码：

55-64

DOI：

10.1016/j.toxlet.2019.04.006

基金类别：

National Key Research and Development Program of China [2017YFC0702700]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21577045]; self-determined research funds of CCNU from the colleges' basic research and operation of MOE [CCNU18JCXK07]

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

摘要：

Formaldehyde (FA), a well-known toxic gas molecule similar to nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), is widely produced endogenously via numerous biochemical pathways, and has a number of physiological roles in the biosystem. We attempted to investigate the vasorelaxant effects of FA and their underlying mechanisms. We found that FA induced vasorelaxant effects on rat aortic rings in a concentration-dependent manner. The NO/cyclic guanosine 5' monophosphate (cGMP) pathway was up-regulated when the rat aortas were treated with FA. The expression of large-conductanc...

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Vasodilatory effect of formaldehyde via the NO/cGMP pathway and the regulation of expression of KATP, BKCa and L-type Ca(2+) channels.

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