The overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity

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成果类型：

期刊论文

作者：

Chen, Xiufang;Wang, Yue;Feng, Tianquan;Yi, Ming;Zhang, Xingan*;...

通讯作者：

Zhou, Da;Zhang, Xingan

作者机构：

[Zhang, Xingan; Chen, Xiufang] Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Peoples R China.

[Zhou, Da] Xiamen Univ, Sch Math Sci, Xiamen 361005, Peoples R China.

[Wang, Yue] Univ Washington, Dept Appl Math, Seattle, WA 98195 USA.

[Feng, Tianquan] Nanjing Normal Univ, Sch Teachers Educ, Nanjing 210023, Jiangsu, Peoples R China.

[Yi, Ming] Huazhong Agr Univ, Dept Phys, Coll Sci, Wuhan 430070, Hubei, Peoples R China.

通讯机构：

[Zhou, Da] X

[Zhang, Xingan] C

Xiamen Univ, Sch Math Sci, Xiamen 361005, Peoples R China.

Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Peoples R China.

语种：

英文

关键词：

cancer;cell organelle;modeling;phenotypic plasticity;Article;cancer cell;cancer stem cell;cell population;cells by body anatomy;comparative study;controlled study;feedback system;human;non stem cancer cell;phenotype;phenotypic plasticity;priority journal;algorithm;biological model;cell dedifferentiation;cell differentiation;cell proliferation;genetics;metabolism;mutation;neoplasm;pathology;physiological feedback;Algorithms;Cell Dedifferentiation;Cell Differentiation;Cell Proliferation;Feedback, Physiological;Humans;Models, Biological;Mutation;Neoplasms;Neoplastic Stem Cells;Phenotype

期刊：

Journal of Theoretical Biology

ISSN：

0022-5193

年：

2016

卷：

390

页码：

40-49

DOI：

10.1016/j.jtbi.2015.11.008

基金类别：

We thank the referees for their helpful comments. X.C. and X.Z. acknowledge the support by NSFC (No. 11371161 ). M.Y. acknowledges NSFC (Nos. 11275259 and 91330113 ). D.Z. acknowledges the generous sponsorship from the National Natural Sciences Foundation of China (No. 11401499 ), the Natural Science Foundation of Fujian Province of China (No. 2015J05016 ),and the Fundamental Research Funds for the Central Universities in China (No. 20720140524 ).

机构署名：

本校为第一且通讯机构

院系归属：

数学与统计学学院

摘要：

The paradigm of phenotypic plasticity indicates reversible relations of different cancer cell phenotypes, which extends the cellular hierarchy proposed by the classical cancer stem cell (CSC) theory. Since it is still questionable if the phenotypic plasticity is a crucial improvement to the hierarchical model or just a minor extension to it, it is worthwhile to explore the dynamic behavior characterizing the reversible phenotypic plasticity. In this study we compare the hierarchical model and the reversible model in predicting the cell-state dynamics observed in biological experiments. Our res...

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The overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity

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