期刊论文

Duan, Jiang;Zhang, AD

英文

Pest Management Science

1526-498X

2024

80

2

846-856

10.1002/ps.7810

The authors gratefully acknowledge the financial supports of the National Natural Science Foundation of China (22277038), the National Key Research and Development Program for Special Projects (2022YFA1207400), and in part by the Fundamental Research Funds [22277038]; National Natural Science Foundation of China [2022YFA1207400]; National Key Research and Development Program for Special Projects [2022CXZZ101]; Fundamental Research Funds for the Central Universities from China

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One fosmidomycin analog containing an aza‐linker is identified that represents the first herbicide lead structure of new mode of action that targets IspC enzyme in the 2‐C‐methyl‐d‐erythritol 4‐phosphate pathway. Abstract BACKGROUND The enzymes involved in the 2‐C‐methyl‐d‐erythritol 4‐phosphate (MEP) pathway are attractive targets of a new mode of action for developing anti‐infective drugs and herbicides, and inhibitors against 1‐deoxy‐d‐xylulose 5‐phosphate reductoisomerase (IspC), the second key enzyme in the pathway, have be...