期刊论文

Yu, Q;Sun, Y

英文

Chemical Engineering Journal

1385-8947

2023

477

147085

10.1016/j.cej.2023.147085

Q. Y. and Y. S. initiated the idea, designed the experiments and wrote the manuscript. Q. Y., Q. L. and L. T. synthesized the materials and conducted all the biological experiments. Y. Z., Q. Z. and H. Z. helped with the material characterization and biological experiments. Q. Y., M. L. and Y. S. meticulously scrutinized and revised manuscript. Q. Y. and Q. L. contributed equally to this work. All authors commented on this manuscript.

本校为通讯机构

The therapeutic efficacy of immunotherapy for most solid tumors is unsatisfactory due to the "immune-cold" nature. As a form of lytic pro-inflammatory programmed cell death, pyroptosis can release abundant immuno-genic damage-associated molecular patterns to extracellular milieu, exhibiting self-cascade amplifying capacity for cancer immunotherapy. However, the activation of the caspase-3-mediated pyroptosis is difficult because mRNA hypermethylation induces the down-regulated GSDME expression. Herein, an integrated strategy to elicit dual pyroptosis pathways is introduced based on calcium sul...