期刊论文

Zhenbo Song<&wdkj&>Lei Liu

英文

Journal of Translational Medicine

1479-5876

2023

21

1

1-18

10.1186/s12967-023-03993-z

This study was supported by grants from the Research Foundation of Jilin Provincial Science & Technology Development (No. 20190304026YY, 20200404124YY, 20200201135JC, 20210204164YY, 20210402051GH), the Foundation of Jilin Province Development and Reform Commission (No. 2020C015), the Foundation of Human Resources and Social Security Department of Jilin Province (No. 2020009), the Fundamental Research Funds for the Central Universities (No. 135130006, 130029804, 111498001, 131004006).

本校为其他机构

The realization of the “microbiota–gut–brain” axis plays a critical role in neuropsychiatric disorders, particularly depression, is advancing rapidly. Matrine is a natural bioactive compound, which has been found to possess potential antidepressant effect. However, the underlying mechanisms of regulation of the “microbiota–gut–brain” axis in the treatment of depression by oral matrine remain elusive. Its antidepressant effects were initially evaluated by behavioral tests and relative levels of monoamine neurotransmitters, and matrine ha...