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Dibutyl Phthalate Adsorbed on Multiwalled Carbon Nanotubes Causes Fetal Developmental Toxicity in Balb/C Mice

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成果类型:
期刊论文
作者:
Qin, Yujie;He, Suli;Peng, Haiyan;Ye, Xin;Zhang, Hongmao*;...
通讯作者:
Zhang, Hongmao;Ding, SM
作者机构:
[Ding, Shumao; Qin, Yujie; He, Suli; Peng, Haiyan; Zhang, Hongmao; Zhang, HM] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
[Ye, Xin] Sichuan Univ Sci & Engn, Coll Bioengn, Liquor Marking Biol Technol & Applicat Key Lab Sic, Yibin 644000, Peoples R China.
通讯机构:
[Ding, SM ; Zhang, HM] C
Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
multiwalled carbon nanotubes;dibutyl phthalate;compound exposure;mice;reproductive toxicity
期刊:
Toxics
ISSN:
2305-6304
年:
2023
卷:
11
期:
7
页码:
565-
基金类别:
This work was supported by the National Natural Science Foundation of China (General Program) (No. 31772471) and the Fundamental Research Funds for the Central Universities (No. CCNU22LJ003). [31772471]; National Natural Science Foundation of China [CCNU22LJ003]; Fundamental Research Funds for the Central Universities
机构署名:
本校为第一且通讯机构
院系归属:
生命科学学院
摘要:
This study investigated whether using multiwalled carbon nanotubes (MWCNTs) as a carrier for dibutyl phthalate (DBP) could delay the degradation rate of DBP in mice and increase its estrogen-like interference effect. Pregnant Balb/C mice were divided into four groups and exposed to different treatments via tail-vein injection every 3 days until gestational day 20. The female and male mice were then sacrificed for toxicological study. The results showed that the combination of MWCNTs and DBP resulted in a higher fetal mortality rate than if the mice were exposed to MWCNTs or DBP alone. H & E st...

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