Platelets derived citrullinated proteins and microparticles are potential autoantibodies ACPA targets in RA patients

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成果类型：

期刊论文

作者：

Xu, Minjie;Du, Rong;Xing, Wenping;Chen, Xueting;Wan, Jian;...

通讯作者：

Geng, H.

作者机构：

[Xiong, Li; Xu, Minjie; Wan, Jian; Chen, Xueting; Geng, Hui; Xing, Wenping] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Peoples R China.

[Du, Rong] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Rheumatol, Wuhan, Peoples R China.

[Wang, Shengqing] Hosp affiliated Cent China Normal Univ, Dept Dermatol, Wuhan, Peoples R China.

[Nandakumar, Kutty Selva] Halmstad Univ, Sch Business, Dept Environm & Biosci, Innovat & Sustainabil, Halmstad, Sweden.

[Holmdahl, Rikard] Karolinska Inst, Dept Med Biochem & Biophys, Div Med Inflammat Res, Stockholm, Sweden.

通讯机构：

[Geng, H.] H

Hubei Key Laboratory of Genetic Regulation and Integrative Biology, China

语种：

英文

关键词：

Rheumatoid arthritis;citrullination;platelets;Anti-citrullinated protein antibodies (ACPA);platelet derived microparticles (PDP)

期刊：

FRONTIERS IN IMMUNOLOGY

ISSN：

1664-3224

年：

2023

卷：

页码：

1084283

DOI：

10.3389/fimmu.2023.1084283

基金类别：

This work was supported by the Natural Science Foundation of China (32170906), Fundamental Research Funds for the Central University of Central China Normal University (CCNU20TS02112), and the Swedish Research Council (2019-01209).

机构署名：

本校为第一机构

院系归属：

生命科学学院

摘要：

Citrullinated neoepitopes have emerged as key triggers of autoantibodies anti-citrullinated protein antibodies (ACPA) synthesis in rheumatoid arthritis (RA) patients. Apart from their critical role in homeostasis and thrombosis, platelets have a significant contribution to inflammation as well. Although anuclear in nature, platelets have an intricate post-translational modification machinery. Till now, citrullination in platelets and its contribution to trigger autoantibodies ACPA production in RA is an unexplored research direction. Herein, we...

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Platelets derived citrullinated proteins and microparticles are potential autoantibodies ACPA targets in RA patients

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