SAXS Examinations of the Redox-Dependent Formation of a DNA-SOD1 Complex

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成果类型：

期刊论文

作者：

Wang, Huiling;Wang, Mingfang;Nie, Zefeng;Qiu, Shuang;Huang, Xiaoping;...

通讯作者：

Changlin Liu

作者机构：

[Wang, Mingfang; Cui, Yanfang; Liu, Chunrong; Wang, Huiling; Huang, Xiaoping; Liu, Changlin; Li, Xiang; Qiu, Shuang; Nie, Zefeng] Cent China Normal Univ, Sch Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.

通讯机构：

[Changlin Liu] K

Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, School of Chemistry, Central China Normal University, Wuhan 430079, China<&wdkj&>Author to whom correspondence should be addressed.

语种：

英文

关键词：

SOD1;DNA;SAXS;redox-dependent binding;HADDOCK docking

期刊：

International Journal of Molecular Sciences

ISSN：

1422-0067

年：

2022

卷：

期：

页码：

12673-

DOI：

10.3390/ijms232012673

基金类别：

This work was supported by grants from NSFC (22077046, 21271079) and a self-determined research fund of the CCNU from the college’s basic research and operation of MOE.

机构署名：

本校为第一机构

院系归属：

化学学院

摘要：

Cu/Zn superoxide dismutase (SOD1) plays a key role in the maintenance of cellular reactive oxygen species (ROS) homeostasis as an antioxidant enzyme. We recently found that SOD1 is involved in the regulation of gene expression in response to changes in cellular ROS levels by binding to DNA-specific sequences. Moreover, the SOD1 binding to DNA was observed to be redox-dependent in solutions. Thus, we examined the redox-dependent DNA binding of SOD1 by multiple measurements, including small-angle X-ray scattering (SAXS), indicating the redox-dependent formation of a DNA-SOD1 complex in solutions...

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SAXS Examinations of the Redox-Dependent Formation of a DNA-SOD1 Complex

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