Order picking is the process of retrieving products from the storage locations to meet customer orders, which accounts for more than 55% of the total warehouse cost. The joint order batching and picker routing problem (JOBPRP) is an effective way to improve picking efficiency. Although many warehouses face the physical constraints of products that have impact on the picking sequence, such as weight, size, shape, and fragility, JOBPRP with such physical constraints has not been widely studied in the literature. This paper is inspired by a practical case observed in an online-to-offline grocery ...