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Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde

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成果类型:
期刊论文
作者:
Huang, Jiawei;Lu, Yu;Zhang, Bin;Yang, Shaoping;Zhang, Qian;...
通讯作者:
Li, Rui
作者机构:
[Cuia, Haiyan; Li, Rui; Yang, Xu; Zhang, Qian; Zhao, Yun; Huang, Jiawei; Lu, Xianxian; Lu, Yu] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
[Zhang, Bin; Yang, Shaoping] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Tongji Med Coll, Wuhan 430016, Hubei, Peoples R China.
通讯机构:
[Li, Rui] C
Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
语种:
英文
关键词:
*EGCG;*Formaldehyde;*Neurotoxicity;*Nrf2;*Oxidative stress
期刊:
Toxicology
ISSN:
0300-483X
年:
2019
卷:
412
页码:
29-36
基金类别:
National Key Research and Development Program of China [2017YFC0702700]
机构署名:
本校为第一且通讯机构
院系归属:
生命科学学院
摘要:
The toxicity of formaldehyde (FA) has always been of great concern, particularly since its use is unavoidable. On the other hand, epigallocatechin-3-gallate (EGCG), an active substance in tea polyphenols, has been shown to demonstrate physiological protective functions by in both epidemiological and zoological studies, particularly in the nervous system. The study described here, aims to explore whether EGCG can alleviate the neurotoxic effects induced by formaldehyde. After 14 days of exposure to 3 mg/m(3) formaldehyde, mice exhibited significant cognitive impairment. In the FA group, a signi...

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