Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xu, Peng;Zhou, Zhe;Xiong, Min;Zou, Wei;Deng, Xuefeng;...

通讯作者：

Liu, Kaiyu;Qiu, Jianming;Wang, Shengqi

作者机构：

[Xu, Peng; Liu, Kaiyu; Peng, Jianxin] Cent China Normal Univ, Sch Life Sci, Wuhan, Peoples R China.

[Xu, Peng; Qiu, Jianming; Zou, Wei; Deng, Xuefeng; Ganaie, Safder S.] Univ Kansas, Med Ctr, Dept Microbiol Mol Genet & Immunol, Kansas City, KS 66103 USA.

[Zhou, Zhe; Wang, Shengqi] Beijing Inst Radiat Med, Dept Biotechnol, Beijing, Peoples R China.

[Ye, Shui Qing; Xiong, Min] Childrens Mercy Hosp, Dept Pediat, Kansas City, MO 64108 USA.

[Ye, Shui Qing; Xiong, Min] Childrens Mercy Hosp, Dept Biomed & Hlth Informat, Kansas City, MO 64108 USA.

通讯机构：

[Liu, Kaiyu] C

[Qiu, Jianming] U

[Wang, Shengqi] B

Cent China Normal Univ, Sch Life Sci, Wuhan, Peoples R China.

Univ Kansas, Med Ctr, Dept Microbiol Mol Genet & Immunol, Kansas City, KS 66103 USA.

语种：

英文

关键词：

Phosphorylation;Cell cycle and cell division;Cyclins;Flow cytometry;DNA replication;Gene expression;Synthesis phase;Transactivation

期刊：

PLOS Pathogens

ISSN：

1553-7366

年：

2017

卷：

期：

页码：

e1006266

DOI：

10.1371/journal.ppat.1006266

基金类别：

NIAID NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01 AI070723] Funding Source: Medline; NIGMS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [P30 GM103326] Funding Source: Medline; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI070723, R01AI070723] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [P30GM103326, P30GM103326, P30GM103326, P30GM103326, P30GM103326, P30GM103326, P30GM103326, P30GM103326, P30GM103326, P30GM103326, P30GM103326, P30GM103326, P30GM103326, P30GM103326, P30GM103326] Funding Source: NIH RePORTER

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

摘要：

Human parvovirus B19 (B19V) infection of primary human erythroid progenitor cells (EPCs) arrests infected cells at both late S-phase and G2-phase, which contain 4N DNA. B19V infection induces a DNA damage response (DDR) that facilitates viral DNA replication but is dispensable for cell cycle arrest at G2-phase; however, a putative C-terminal transactivation domain (TAD2) within NS1 is responsible for G2-phase arrest. To fully understand the mechanism underlying B19V NS1-induced G2-phase arrest, we established two doxycycline-inducible B19V-perm...

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Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway

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